{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:15:17Z","timestamp":1777864517171,"version":"3.51.4"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    Primary cardiac tumors are uncommon, with an incidence rate ranging from 0.001\u2030 to 0.3\u2030. Among cardiac tumors, 75% are benign and 25% are malignant. Approximately 50% of benign cardiac tumors are myxomas, while 75% of malignant cardiac tumors are sarcomas. Compared with myxomas, malignant cardiac tumors have a poorer prognosis. Cardiac myxosarcomas often have an insidious onset in young and middle-aged patients, with an overall survival period of 6 to 12 months. Similar to soft tissue tumors, cardiac sarcomas also consist of a range of histological subtypes. Among these, cardiac myxosarcomas are extremely rare, with only a few case reports documented in domestic and international literature to date. Due to similarities in imaging findings, they are often diagnosed as myxomas preoperatively, which may lead to insufficient resection during surgery. Owing to similarities in gross and histological features, coupled with the rarity of such cases, a small number of cases are misdiagnosed as myxomas in postoperative pathological examinations, and a definitive diagnosis is only made upon recurrence. This paper reports a case of a 23-year-old male patient with congenital heart disease and atrial septal defect, who had a history of interventional occlusion for atrial septal defect 12 years ago. The patient was admitted to the hospital for a rare giant myxosarcoma involving both atria, manifesting as rapidly progressive hemodynamic compromise. He underwent surgical resection of the cardiac tumor, and the pathological diagnosis was cardiac myxosarcoma. The tumor demonstrated highly malignant biological behavior. Rapid postoperative recurrence occurred, resulting in a short survival period. The patient eventually died of vena cava obstruction, heart failure and multiple organ failure secondary to tumor recurrence.\n                  <\/jats:p>","DOI":"10.3389\/fsurg.2026.1765767","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:42:48Z","timestamp":1777527768000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Giant myxosarcoma involving both atria"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianbo","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital of Zhejiang University School of Medicine","place":["Jinhua, Zhejiang Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital of Zhejiang University School of Medicine","place":["Jinhua, Zhejiang Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianshuai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Jinhua Municipal Central Hospital, Affiliated Jinhua Hospital of Zhejiang University School of Medicine","place":["Jinhua, Zhejiang Province, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0003-4975(98)00591-8","article-title":"Surgical experience with intracardiac myxomas: long-term follow-up","volume":"66","author":"Bhan","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"B2","first-page":"47","article-title":"Primary malignant cardiac tumors","volume":"34","author":"Zhai","year":"1994","journal-title":"Shandong Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/00004728-199705000-00023","article-title":"MRI of primary malignant cardiovascular tumors","volume":"21","author":"Siripornpitak","year":"1997","journal-title":"J Comput Assist Tomogr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"165e","DOI":"10.1700\/1217.13514","article-title":"Primary cardiac myxofibrosarcoma: a case report and review of the literature","volume":"98","author":"Wang","year":"2012","journal-title":"Tumori"},{"key":"B5","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1540-8175.2008.00860.x","article-title":"Large obstructive cardiac myxofibrosarcoma is nearly invisible on transthoracic echocardiogram","volume":"26","author":"Heletz","year":"2009","journal-title":"Echocardiography"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/j.athoracsur.2013.11.056","article-title":"Myxoid fibrosarcoma of the left atrium and ventricle in pregnancy","volume":"98","author":"Zhang","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1177\/0218492312450291","article-title":"Right-sided low grade myxofibrosarcoma of the heart in an adult","volume":"21","author":"Gupta","year":"2013","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"B8","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.ihj.2013.11.002","article-title":"A butterfly shaped mobile bia trial cardiac mass: myxoma or something else","volume":"66","author":"Gupta","year":"2014","journal-title":"Indian Heart J"},{"key":"B9","first-page":"334","volume-title":"WHO classification of Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis","year":"2015"},{"key":"B10","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13019-016-0490-3","article-title":"A case report of primary cardiac myxofibrosarcoma presenting with severe congestive heart failure","volume":"11","author":"Ujihira","year":"2016","journal-title":"J Cardiothorac Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.humpath.2008.01.019","article-title":"Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival","volume":"39","author":"Zhang","year":"2008","journal-title":"Hum Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.athoracsur.2010.03.065","article-title":"Primary cardiac sarcoma","volume":"90","author":"Hamidi","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"B13","first-page":"296","article-title":"Cardiac autotransplantation for malignant or complex primary left-heart tumors","volume":"35","author":"Blackmon","year":"2008","journal-title":"Tex Heart Inst J"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1765767\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:43:12Z","timestamp":1777527792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1765767\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,30]]},"references-count":13,"alternative-id":["10.3389\/fsurg.2026.1765767"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2026.1765767","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,30]]},"article-number":"1765767"}}