{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:10:48Z","timestamp":1780405848115,"version":"3.54.1"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Mesenteric fibromatosis (MF) is a rare, locally aggressive, borderline tumor with no metastatic potential, characterized by a high postoperative recurrence rate. This paper reports a complex case of aggressive MF. Despite receiving targeted therapy that was combined with immunotherapy, the tumor in our case progressed rapidly and symptoms of intestinal obstruction developed. Following a challenging radical resection, delayed and complex multiple complications ensued, including duodenal fistula, vaginal fistula, and ureterorectal fistula. Through personalized management under multidisciplinary team (MDT) collaboration\u2014including adequate drainage to control infection, stepwise nutritional support (i.e., transitioning from total parenteral nutrition to enteral nutrition), and targeted management of a high-output enterostomy\u2014the patient ultimately recuperated with drainage tubes in place, and she was able to tolerate oral feeding. This case suggests that for giant mesenteric fibromatosis that continues to progress despite medical therapy, close imaging surveillance (particularly vigilance for signs of \"tension cystic change\") should be employed to warn of serious complications, and a decisive, surgery-centered multidisciplinary comprehensive treatment strategy should be adopted. Postoperatively, reliance on a multidisciplinary team is essential for long-term vigilance against delayed complex fistulae triggered by factors such as infection. The diagnostic and therapeutic experience from this case provides an important reference for managing this highly challenging disease.<\/jats:p>","DOI":"10.3389\/fsurg.2026.1785029","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:26:38Z","timestamp":1780403198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and treatment of multiple postoperative fistulas following resection of a giant abdominal mesenteric fibromatosis: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Weihua","family":"Zheng","sequence":"first","affiliation":[{"name":"Foundational and Translational Medical Research Center, Hohhot First Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Hohhot First Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Hohhot First Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hohhot First Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Hohhot First Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Hohhot First Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12876-020-01592-6","article-title":"Transverse colonic volvulus due to mesenteric fibromatosis: a case report","volume":"21","author":"Yoshida","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/annonc\/mdr386","article-title":"Update on desmoid tumors","volume":"23","author":"Escobar","year":"2012","journal-title":"Ann Oncol"},{"key":"B3","first-page":"283","article-title":"Primary mesenteric fibromatosis: a single center experience","volume":"91","author":"Yalav","year":"2020","journal-title":"Ann Ital Chir"},{"key":"B4","doi-asserted-by":"publisher","first-page":"641","DOI":"10.14670\/HH-27.641","article-title":"FAP-related desmoid tumors: a series of 44 patients evaluated in a cancer referral center","volume":"27","author":"Colombo","year":"2012","journal-title":"Histol Histopathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e8735","DOI":"10.1002\/ccr3.8735","article-title":"A rare case of gardner syndrome in an African adult male: a case report","volume":"12","author":"Olaopa","year":"2024","journal-title":"Clin Case Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3892\/mco.2023.2680","article-title":"Extra-abdominal recurrent aggressive fibromatosis: a case series and a literature review","volume":"19","author":"Asaad","year":"2023","journal-title":"Mol Clin Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"znaf013","DOI":"10.1093\/bjs\/znaf013","article-title":"Multicentre prospective study on the diagnostic and prognostic validity of malnutrition assessment tools in surgery","volume":"112","author":"Petra","year":"2025","journal-title":"Br J Surg"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1785029\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:26:38Z","timestamp":1780403198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1785029\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":7,"alternative-id":["10.3389\/fsurg.2026.1785029"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2026.1785029","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"article-number":"1785029"}}