{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:49:25Z","timestamp":1782107365020,"version":"3.54.5"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the effect of laparoscopic ovarian cystectomy on ovarian reserve function and its related risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data of 150 patients with unilateral ovarian cysts admitted to our hospital were retrospectively analyzed. Paired t-tests were used to compare changes in indicators before and after surgery. One-way analysis of variance was performed to compare differences among different groups. Multivariable logistic regression analysis was used to identify independent risk factors for significant postoperative AMH decrease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 1, 3, 6, and 12 months after surgery, the AMH levels were significantly lower than those before surgery, while the FSH levels were higher than those before surgery (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). At 12 months after surgery, the decrease in AMH levels and the increase in FSH levels in the cyst diameter \u22657\u2005cm group were significantly greater than those in the cyst diameter &amp;lt;5\u2005cm and 5\u2009\u2212\u20097\u2005cm groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). The decrease in AMH and the increase in FSH in the electrocoagulation hemostasis group were significantly greater than those in the suture hemostasis group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Among 86 patients with fertility intentions, the overall pregnancy rate was 59.3% (51\/86), and the live birth rate was 48.8% (42\/86). Multivariable logistic regression analysis showed that cyst diameter \u22657\u2005cm (OR\u2009=\u20093.610, 95%CI: 1.835\u2009\u2212\u20097.103), endometriotic cysts (OR\u2009=\u20092.063, 95%CI: 1.106\u20133.848), electrocoagulation hemostasis (OR\u2009=\u20092.633, 95%CI: 1.232\u2009\u2212\u20095.627), and moderate-to-severe ovarian tissue loss (OR\u2009=\u20094.697, 95%CI: 2.312\u2009\u2212\u20099.545) were independent risk factors for significant postoperative AMH decrease (\u226530%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Laparoscopic ovarian cystectomy causes some damage to ovarian reserve function. After surgery, AMH levels decrease and FSH levels increase, but these levels gradually recover over time. Larger cyst diameter, endometriotic cysts, electrocoagulation hemostasis, and moderate-to-severe ovarian tissue loss are independent risk factors for postoperative ovarian reserve function damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1822536","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:39:37Z","timestamp":1782106777000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in ovarian reserve function after laparoscopic ovarian cystectomy: a retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Juan","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Aviation General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Aviation General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Aviation General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Aviation General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"B1","first-page":"499","article-title":"Pregnancy complicated by ovarian cysts","volume":"22","author":"Shakya","year":"2024","journal-title":"Kathmandu Univ Med J (KUMJ)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/gme.0000000000002163","article-title":"Natural history and malignant potential of simple ovarian cysts in postmenopausal women: a systematic review and meta-analysis","volume":"30","author":"Liu","year":"2023","journal-title":"Menopause (New York, NY)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.3390\/jcm14041236","article-title":"Giant ovarian tumors in young women: diagnostic and treatment challenges-A report of two cases and narrative review of the recent literature","volume":"14","author":"Melnyk","year":"2025","journal-title":"J Clin Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1517789","DOI":"10.3389\/fendo.2025.1517789","article-title":"The influence of ovarian cyst type and size on ovarian reserve markers: implications for fertility counseling and preservation strategy","volume":"16","author":"Sun","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"781","DOI":"10.5603\/gpl.96393","article-title":"The role of anti-m\u00fcllerian hormone in women health","volume":"96","author":"Czerwonogrodzka-Senczyna","year":"2025","journal-title":"Ginekol Pol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"173","DOI":"10.17305\/bb.2025.12070","article-title":"Anti-M\u00fcllerian hormone in PCOS: molecular regulation and emerging therapeutic strategies","volume":"26","author":"Ke","year":"2025","journal-title":"Biomol Biomed"},{"key":"B7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12020-025-04265-0","article-title":"The role of anti-m\u00fcllerian hormone: insights into ovarian reserve, primary ovarian insufficiency, and menopause prediction","volume":"89","author":"Karaviti","year":"2025","journal-title":"Endocrine"},{"key":"B8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4103\/ijabmr.ijabmr_81_24","article-title":"Correlation of follicle-stimulating hormone, anti-mullerian hormone, and antral follicle count with age in ovarian reserve testing","volume":"14","author":"Das","year":"2024","journal-title":"Int J Appl Basic Med Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4103\/0974-1208.138871","article-title":"Laparoscopic cystectomy of endometrioma: good surgical technique does not adversely affect ovarian reserve","volume":"7","author":"Bhat","year":"2014","journal-title":"J Hum Reprod Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1093\/humrep\/deac204","article-title":"Anti-M\u00fcllerian hormone-mediated preantral follicle atresia is a key determinant of antral follicle count in mice","volume":"37","author":"Zhou","year":"2022","journal-title":"Hum Reprod (Oxford, England)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1093\/humrep\/deac082","article-title":"Association between an AMH promoter polymorphism and serum AMH levels in PCOS patients","volume":"37","author":"Moolhuijsen","year":"2022","journal-title":"Hum Reprod (Oxford, England)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/ijgo.70610","article-title":"Is systemic inflammation associated with reduced ovarian reserve in endometriosis? An investigation of anti-m\u00fcllerian hormone and inflammatory markers","volume":"173","author":"Ulger","year":"2025","journal-title":"Int J Gynaecol Obstet"},{"key":"B13","first-page":"312","article-title":"Systematic review and meta-analysis: impact of Various hemostasis methods on ovarian reserve function in laparoscopic cystectomy for ovarian endometriomas","volume":"30","author":"Gao","year":"2024","journal-title":"Altern Ther Health Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"102524","DOI":"10.1016\/j.bpobgyn.2024.102524","article-title":"Impact of surgery on reproductive outcomes in women with deep endometriosis and proven presurgical infertility: facts and controversies.","volume":"96","author":"Etrusco","year":"2024","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13645706.2023.2274396","article-title":"Outcomes of conventional and advanced energy devices in laparoscopic surgery: a systematic review","volume":"33","author":"Abi Antoun","year":"2024","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e24196","DOI":"10.1002\/ajhb.24196","article-title":"Inflammation and ovarian function in reproductive-aged women","volume":"37","author":"Long","year":"2025","journal-title":"Am J Hum Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"20408","DOI":"10.1038\/s41598-024-71611-z","article-title":"Estimation of the difference between peritoneal microenvironment and core body temperature during laparoscopic surgery - a prospective observational study","volume":"14","author":"Mazzinari","year":"2024","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5515559","DOI":"10.1155\/2021\/5515559","article-title":"Effects of heated pneumoperitoneum on inflammation, oxidative stress, and peritoneal histology in female dogs that underwent video-assisted ovariohysterectomy","volume":"2021","author":"Milech","year":"2021","journal-title":"Vet Med Int"},{"key":"B19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1186\/s13063-021-05431-1","article-title":"Preservation of the ovarian reserve and hemostasis during laparoscopic ovarian cystectomy by a hemostatic agent versus suturing for patients with ovarian endometriosis: study protocol for randomized controlled, non-inferiority trial (PRAHA-2 trial)","volume":"22","author":"Lim","year":"2021","journal-title":"Trials"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6442","DOI":"10.3748\/wjg.v27.i38.6442","article-title":"High total joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection","volume":"27","author":"Ochi","year":"2021","journal-title":"World J Gastroenterol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00404-024-07926-z","article-title":"Long-term effects of bipolar electrocoagulation and suture hemostasis on the ovarian reserve following endometriotic cystectomy: a meta-analysis","volume":"312","author":"Wang","year":"2025","journal-title":"Arch Gynecol Obstet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2320294","DOI":"10.1080\/01443615.2024.2320294","article-title":"Impact of haemostasis methods during ovarian cystectomy on ovarian reserve: a pairwise and network meta-analysis","volume":"44","author":"Xie","year":"2024","journal-title":"J Obstet Gynaecol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"868","DOI":"10.36740\/WLek202005106","article-title":"Estimation to efficiency of the multifunction method \u043ef endometriosis ovari\u0435s treatment","volume":"73","author":"Nikitina","year":"2020","journal-title":"Wiad Lek (Warsaw, Poland: 1960)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"8495","DOI":"10.1038\/s41598-021-87965-7","article-title":"A randomized controlled trial of ovarian reserve preservation and hemostasis during ovarian cystectomy","volume":"11","author":"Park","year":"2021","journal-title":"Sci Rep"},{"key":"B25","first-page":"29","article-title":"Laparoscopic cystectomy in treating women with endometrioma and pregnancy outcome - a case series","volume":"76","author":"Supermaniam","year":"2021","journal-title":"Med J Malaysia"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s00404-020-05483-9","article-title":"A new approach to avoid ovarian failure as well function-impairing adhesion formation in endometrioma infertility surgery","volume":"301","author":"Torres-de la Roche","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"B27","year":"2022"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.fertnstert.2019.09.013","article-title":"Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion","volume":"112","year":"2019","journal-title":"Fertil Steril"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1822536\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:39:39Z","timestamp":1782106779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1822536\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":28,"alternative-id":["10.3389\/fsurg.2026.1822536"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2026.1822536","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"article-number":"1822536"}}