{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:10:51Z","timestamp":1784182251946,"version":"3.55.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>This study reports a rare case in which the integration of Thyroglobulin measurement in the needle washout after fine-needle aspiration (FNA-Tg) and BRAF V600E analysis rectified a histopathological misdiagnosis of cervical lymph node metastasis originating from papillary thyroid carcinoma. The patient was a 52-year-old female farmer who presented with a diagnosis of papillary thyroid carcinoma. Histopathological assessment of cervical lymph nodes returned negative findings, whereas both FNA-Tg and BRAF V600E are positive results. Following a comprehensive re-evaluation of the histopathological specimens, a definitive diagnosis of a rare case of cervical lymph node micrometastasis was confirmed. This case report provides a systematic review of the current literature and critically examines the diagnostic utility of combining FNA-Tg with BRAF V600E in the detection of cervical lymph node metastases from PTC, potentially offering a therapeutic strategy for the clinical management of such conditions.<\/jats:p>","DOI":"10.3389\/fsurg.2026.1837054","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:39:25Z","timestamp":1784180365000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive value and clinical guidance of FNA-Tg combined with BRAF V600E for PTC cervical lymph node metastasis: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Wen-shi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery, The Affiliated Tengzhou Central People\u2019s Hospital of Xuzhou Medical University","place":["Tengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, The Affiliated Tengzhou Central People\u2019s Hospital of Xuzhou Medical University","place":["Tengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-rui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of the Pathology, The Affiliated Tengzhou Central People\u2019s Hospital of Xuzhou Medical University","place":["Tengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Operating Room, The Affiliated Tengzhou Central People\u2019s Hospital of Xuzhou Medical University","place":["Tengzhou, 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