{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:04:41Z","timestamp":1780380281409,"version":"3.54.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Intramedullary solitary fibrous tumor is an exceptionally rare spindle-cell neoplasm of the central nervous system and is rarely diagnosed before surgery because the clinical presentation and imaging findings are non-specific. We report a man in his early 60s with more than 7 years of progressive bilateral lower-extremity numbness that worsened during the month before admission without an identifiable precipitating event. Magnetic resonance imaging demonstrated an enhancing intramedullary lesion at the C7-T1 level. The patient underwent microscopic tumor resection through a posterior C7-T2 laminectomy under intraoperative ultrasound guidance and multimodal intraoperative neurophysiological monitoring, including somatosensory evoked potentials, transcranial motor evoked potentials, D-wave monitoring, and free-running electromyography. Gross total resection was achieved without new neurological deficit. Histology showed spindle cells in fascicular and storiform arrangements with branching staghorn-like vessels. Immunohistochemistry demonstrated nuclear STAT6 positivity with co-expression of CD34, CD99, and Bcl-2. Mitotic activity was low, with only 2\u20133 mitoses per 10 high-power fields, and no definite tumor necrosis was identified, supporting the diagnosis of a CNS WHO grade 1 solitary fibrous tumor. Sensory symptoms improved after surgery, and no recurrence was detected on magnetic resonance imaging at 18-month follow-up. This short-term outcome is encouraging, but long-term radiological surveillance remains necessary.<\/jats:p>","DOI":"10.3389\/fsurg.2026.1845706","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:43:03Z","timestamp":1780378983000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Intramedullary solitary fibrous tumor at the C7-T1 level diagnosed by STAT6 and treated with maximal safe resection"],"prefix":"10.3389","volume":"13","author":[{"given":"Changli","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]},{"name":"Anhui Digital Brain Engineering Research Center, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]},{"name":"Anhui Digital Brain Engineering Research Center, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College","place":["Wuhu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.3390\/cancers14122839","article-title":"Spinal solitary fibrous tumors: an original multicenter series and systematic review of presentation, management, and prognosis","volume":"14","author":"Apra","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"189.e7","DOI":"10.1016\/j.wneu.2015.02.036","article-title":"Intramedullary solitary fibrous tumor-a benign form of hemangiopericytoma? 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