{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:24:03Z","timestamp":1787207043292,"version":"build-2736575974"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple penile condylomata acuminata (CA) often involve the inner foreskin and frenulum. This retrospective study compared conventional sleeve and disposable circular stapler circumcision, each combined with ablation of visible lesions, in selected patients with multiple penile CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients aged 18\u201355 years with at least 5 visible lesions involving the foreskin and\/or frenulum who underwent treatment between January 2020 and December 2024 were screened. Propensity-score matching (1:1 nearest neighbor, caliper 0.05) using prespecified covariates yielded 41 patients per group. Outcomes included operative time, blood loss, complications, baseline and 12-month IIEF-15, cosmetic appearance, patient satisfaction, and 12-month recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, baseline characteristics were well balanced (all standardized mean differences &amp;lt;0.1). Compared with sleeve circumcision, stapler circumcision was associated with shorter operative time (mean difference \u221214.2\u2005min, 95% CI \u221216.7 to \u221211.7), less blood loss (mean difference \u22127.5\u2005mL, 95% CI \u22129.2 to \u22125.8), higher patient- and surgeon-rated cosmetic scores (mean differences 0.7 and 0.8, respectively), and higher patient satisfaction (mean difference 0.7). IIEF-15 scores were similar. Recurrence occurred in 6\/41 (14.6%) stapler patients and 8\/41 (19.5%) sleeve patients (risk difference \u22124.9%, 95% CI \u221221.1% to 11.4%; odds ratio 0.71, 95% CI 0.22 to 2.26). No major complications occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single-center retrospective matched cohort of carefully selected patients without anatomical contraindications to stapler placement, stapler circumcision was associated with perioperative and patient-reported advantages. The recurrence estimate was imprecise and does not establish equivalence or non-inferiority. These findings are hypothesis-generating and require confirmation in larger prospective studies with longer follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1846470","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:28:57Z","timestamp":1787203737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stapler vs. sleeve circumcision for multiple penile condylomata acuminata: a comparative study"],"prefix":"10.3389","volume":"13","author":[{"given":"Haoran","family":"Chen","sequence":"first","affiliation":[{"name":"Department of General Surgery, Hangzhou Third People\u2019s Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangfeng","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Urology, Hangzhou Third People\u2019s Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Hangzhou Third People\u2019s Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, Hangzhou Third People\u2019s Hospital","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1111\/jdv.16522","article-title":"2019 IUSTI-Europe guideline for the management of anogenital warts","volume":"34","author":"Gilson","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1177\/09564624241233338","article-title":"British Association for sexual health and HIV national guideline for the management of anogenital warts in adults (2024)","volume":"35","author":"Nugent","year":"2024","journal-title":"Int J STD AIDS"},{"key":"B4","doi-asserted-by":"publisher","first-page":"362","DOI":"10.4103\/1008-682X.174855","article-title":"Use of a disposable circumcision suture device versus conventional circumcision: a systematic review and meta-analysis","volume":"19","author":"Huo","year":"2017","journal-title":"Asian J Androl"},{"key":"B5","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1590\/1414-431X20154530","article-title":"Adult male circumcision with a circular stapler versus conventional circumcision: a prospective randomized clinical 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meta-regression","volume":"29","author":"Shapiro","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"B9","doi-asserted-by":"publisher","first-page":"S631","DOI":"10.1086\/652184","article-title":"Male circumcision and the risks of HPV infection and genital warts: a systematic review","volume":"224","author":"Lu","year":"2021","journal-title":"J Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1687","DOI":"10.1016\/j.cmi.2023.03.028","article-title":"Voluntary medical male circumcision for HIV and HPV prevention and its wider health benefits","volume":"10","author":"Grund","year":"2022","journal-title":"Lancet Glob Health"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1158\/1055-9965.EPI-20-1272","article-title":"Male circumcision reduces penile HPV incidence and persistence: a randomized controlled trial in Kenya","volume":"30","author":"Smith","year":"2021","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2170662","DOI":"10.1080\/21645515.2023.2170662","article-title":"Epidemiology of human papillomavirus on condyloma acuminatum in Shandong Province, China","volume":"19","author":"Yuan","year":"2023","journal-title":"Hum Vaccin Immunother"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.3390\/diagnostics14161790","article-title":"Exploring the multifactorial landscape of penile cancer: a comprehensive analysis of risk factors","volume":"14","author":"Amicuzi","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"B14","doi-asserted-by":"publisher","first-page":"552028","DOI":"10.3389\/fpubh.2020.552028","article-title":"Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation","volume":"8","author":"Kombe Kombe","year":"2021","journal-title":"Front Public Health"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1846470\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:28:58Z","timestamp":1787203738000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1846470\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":14,"alternative-id":["10.3389\/fsurg.2026.1846470"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2026.1846470","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"article-number":"1846470"}}