{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:01:19Z","timestamp":1790283679196,"version":"4.1.0"},"reference-count":135,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>The evolution of thoracic surgery from open thoracotomy to uniportal video-assisted thoracoscopic surgery (U-VATS) represents a paradigm shift toward minimizing surgical trauma. However, the changing landscape of thoracic oncology\u2014characterized by an increase in subsolid nodules, multifocal ground-glass opacities, and locally advanced disease requiring neoadjuvant therapy\u2014demands more than surgical innovation alone. This review explores the critical intersection of U-VATS with multidisciplinary collaboration. We examine how the integration of medical oncology, interventional pulmonology, and radiology enhances the capabilities of the single-port approach. This review will discuss specific combinatorial techniques, including uniportal lung resection following neoadjuvant treatment, navigation bronchoscopic-guided localization strategies, and combining U-VATS with concomitant transbronchial ablation. 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