{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:46:13Z","timestamp":1785735973509,"version":"3.56.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Histiocytic sarcoma is an exceptionally rare and highly aggressive neoplasm that exhibits the morphological and immunophenotypic hallmarks of mature histiocytes. It is characterized typically by extranodal presentation and a dismal clinical course, particularly in patients with disseminated disease. A history of hematolymphoid disorder can be identified in a subset of patients, suggesting transdifferentiation of a preexisting hematolymphoid neoplasm in its pathogenesis. A 38-year-old male patient presented for consultation following the detection of a gastric mass during a routine health examination. Subsequent multimodal evaluation, comprising abdominal computed tomography (CT), positron emission tomography-CT, and gastroscopy, indicated a high probability of malignancy, necessitating surgical resection. Comprehensive histopathological and immunohistochemical analyses confirmed the diagnosis of HS, and next-generation sequencing further corroborated this diagnosis. Despite surgical intervention, the patient succumbed to rapid disease progression within six months, further highlighting the intractable nature of this rare malignancy.<\/jats:p>","DOI":"10.3389\/fsurg.2026.1884156","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:31:29Z","timestamp":1785735089000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric histiocytic sarcoma: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Mingyu","family":"Li","sequence":"first","affiliation":[{"name":"Medical Imaging Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Medical College of 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