{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:27:09Z","timestamp":1787120829276,"version":"build-2736575974"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Extragingival pyogenic granuloma (PG) of the lower labial mucosa is rare during pregnancy, with only a few cases previously reported. This report describes the management of a PG on the lower labial mucosa in a 26-year-old patient at 18 weeks of gestation, representing the earliest reported gestational presentation requiring surgical intervention. The patient presented with a progressively enlarging mass and recurrent bleeding. Given these clinical indications and the lack of established safety data for non-surgical treatments during pregnancy, surgical excision was performed under local anesthesia using lidocaine without epinephrine rather than deferring treatment until after delivery. Histopathology confirmed lobular capillary hemangioma with surface ulceration. At 3-month follow-up, no recurrence was observed, and both maternal and fetal conditions remained stable. This case demonstrates that surgical excision during the second trimester under local anesthesia is feasible and safe, and provides a perioperative management reference for clinicians facing similar cases.<\/jats:p>","DOI":"10.3389\/fsurg.2026.1913013","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:44:23Z","timestamp":1787118263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pyogenic granuloma of the lower labial mucosa during pregnancy: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Heng","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Stomatology, Maternity & Child Healthcare Hospital of Longgang District, [Affiliated Shenzhen Women and Children\u2019s Hospital (Longgang) of Shantou University Medical College]","place":["ShenZhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiashan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Maternity & Child Healthcare Hospital of Longgang District, [Affiliated Shenzhen Women and Children\u2019s Hospital (Longgang) of Shantou University Medical College]","place":["ShenZhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouhuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Maternity & Child Healthcare Hospital of Longgang District, [Affiliated Shenzhen Women and Children\u2019s Hospital (Longgang) of Shantou University Medical College]","place":["ShenZhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/cup.13970","article-title":"Oral pyogenic granuloma: an 18-year retrospective clinicopathological and immunohistochemical study","volume":"48","author":"Ribeiro","year":"2021","journal-title":"J Cutan Pathol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.joms.2009.07.070","article-title":"Oral pyogenic granuloma: a retrospective analysis of 293 cases in a Brazilian population","volume":"68","author":"Gord\u00f3n-N\u00fa\u00f1ez","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/00001665-200503000-00022","article-title":"A case of giant nasal pyogenic granuloma gravidarum","volume":"16","author":"Choudhary","year":"2005","journal-title":"J Craniofac Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.3390\/jcm13030707","article-title":"Oral manifestations in pregnant women: a systematic review","volume":"13","author":"Pecci-Lloret","year":"2024","journal-title":"J Clin Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1902\/jop.2002.73.7.701","article-title":"Pathogenetic roles of angiogenic factors in pyogenic granulornas in pregnancy are modulated by female sex hormones","volume":"73","author":"Yuan","year":"2002","journal-title":"J Periodontol"},{"key":"B6","first-page":"179","article-title":"Pregnancy-associated pyogenic granuloma of the lip: a case report","volume":"20","author":"Adeyemo","year":"2011","journal-title":"Niger J Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.15517\/ijds.v0i0.26633","article-title":"Pyogenic granuloma on the lower lip. 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