{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:40Z","timestamp":1789657540848,"version":"4.0.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute appendicitis is the most common non-obstetric surgical emergency in pregnancy. Diagnosis is difficult due to atypical symptoms, anatomical changes, and limited imaging utility, while delayed diagnosis increases maternal-fetal risks. This study compared clinical, laboratory, imaging and perioperative outcomes between pregnant and non-pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis included a multi-centered retrospective case-control study from July 1, 2020 to December 30, 2025. The operative characteristics involved in the pregnancy women were investigated using univariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 99 pregnant women and 186 non-pregnant reproductive-age women underwent surgery enrolled in this research. Pregnant patients had lower right lower quadrant tenderness (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.046) and lower ultrasound sensitivity (46.5% vs. 53.2%). MRI showed 100% diagnostic accuracy. Pregnant women had higher open conversion rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), longer hospital stay (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0056) and higher histologically negative appendectomies (14.1% vs. 9.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Laparoscopic rate decreased with gestational age. Most complications were minor.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Acute appendicitis in pregnancy presents atypically with lower ultrasound sensitivity. MRI improves diagnostic accuracy. Laparoscopic appendectomy is safe and feasible in pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1914944","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:30:26Z","timestamp":1789655426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute appendicitis during pregnancy: a case-control study"],"prefix":"10.3389","volume":"13","author":[{"given":"Bijian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgical Alliance, Maternal and Child Health System of Chongqing","place":["Chongqing, China"]},{"name":"Department of Pediatric General Surgery, Hechuan Maternal and Child Health Hospital","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Surgical Alliance, Maternal and Child Health System of Chongqing","place":["Chongqing, China"]},{"name":"Department of Pediatric General Surgery, Chongqing Maternal and Child Health Hospital, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Surgical Alliance, Maternal and Child Health System of Chongqing","place":["Chongqing, China"]},{"name":"Department of Pediatric Surgery, Qijiang Health Center for Maternal and Child Care","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Surgical Alliance, Maternal and Child Health System of Chongqing","place":["Chongqing, China"]},{"name":"Department of Pediatric General Surgery, Chongqing Maternal and Child Health Hospital, Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ijsu.2015.01.025","article-title":"Impact of appendicitis during pregnancy: no delay in accurate diagnosis and treatment","volume":"15","author":"Aggenbach","year":"2015","journal-title":"Int J Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2160629","DOI":"10.1080\/14767058.2022.2160629","article-title":"Appendectomy during pregnancy: rates, safety, and outcomes over a five-year period. 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