{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:11Z","timestamp":1790834471596,"version":"4.1.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Lung cancer is increasingly a disease of older age, and as low-dose computed tomography screening extends into the ninth decade, a growing number of octogenarians present with early-stage, potentially curable non-small cell lung cancer. Faced with these patients, clinicians repeatedly ask a single question: is this patient too old for surgery? Recent prospective data show that selected octogenarians achieve long-term survival comparable to younger patients despite substantially higher complication rates, with quality of life that recovers over the first postoperative year. Yet the favorable result is attributed to careful selection that is rarely defined, and is seldom accompanied by any account of the patients who were assessed and not offered an operation. This article argues that chronological age is the wrong axis for the decision. Physiologic reserve, measurable through validated frailty instruments and established physiologic testing, predicts postoperative outcome far better than birth year, and aging is sufficiently heterogeneous that any age threshold misclassifies patients in both directions. A substantial competing risk of non-cancer death, compounded by overdiagnosis among screen-detected tumors, tempers the survival gain expected from aggressive treatment and makes overtreatment as real a hazard as age-based exclusion. A graded menu of options now exists, extending from minimally invasive lobectomy through sublobar resection and stereotactic ablative radiotherapy to active surveillance, and intensity should descend with reserve rather than with age. The task is to operationalize careful selection through structured geriatric assessment, multidisciplinary collaboration, prehabilitation, and shared decision-making, and to judge success by outcomes that older patients actually value.<\/jats:p>","DOI":"10.3389\/fsurg.2026.1961761","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:42:04Z","timestamp":1790833324000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age is the wrong axis: rethinking surgical selection for octogenarians with early-stage non-small cell lung cancer"],"prefix":"10.3389","volume":"13","author":[{"given":"Vasiliki","family":"Androutsopoulou","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine, University of Thessaly, Biopolis","place":["Larissa, 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