{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:24:04Z","timestamp":1779103444209,"version":"3.51.4"},"reference-count":194,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Biol."],"abstract":"<jats:p>The human malaria parasite, <jats:italic>Plasmodium<\/jats:italic> falciparum<jats:italic>,<\/jats:italic> is a unicellular protozoan responsible for over half a million deaths annually. With a complex life cycle alternating between human and invertebrate hosts, this apicomplexan is notoriously adept at evading host immune responses and developing resistance to all clinically administered treatments. Advances in omics-based technologies, increased sensitivity of sequencing platforms and enhanced CRISPR based gene editing tools, have given researchers access to more in-depth and untapped information about this enigmatic micro-organism, a feat thought to be infeasible in the past decade. Here we discuss some of the most important scientific achievements made over the past few years with a focus on novel technologies and platforms that set the stage for subsequent discoveries. We also describe some of the systems-based methods applied to uncover gaps of knowledge left through single-omics applications with the hope that we will soon be able to overcome the spread of this life-threatening disease.<\/jats:p>","DOI":"10.3389\/fsysb.2022.940321","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T12:30:51Z","timestamp":1663331451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Decrypting the complexity of the human malaria parasite biology through systems biology approaches"],"prefix":"10.3389","volume":"2","author":[{"given":"Zeinab","family":"Chahine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine G.","family":"Le Roch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e26623","DOI":"10.1371\/journal.pone.0026623","article-title":"Clinical proteomics of the neglected human malarial parasite Plasmodium vivax","volume":"6","author":"Acharya","year":"2011","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/prot.20278","article-title":"A genomic perspective of protein kinases in Plasmodium falciparum","volume":"58","author":"Anamika","year":"2005","journal-title":"Proteins"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1038\/s41591-020-1084-0","article-title":"Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season","volume":"26","author":"Andrade","year":"2020","journal-title":"Nat. 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