{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:14:56Z","timestamp":1783512896460,"version":"3.55.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013060","name":"European Molecular Biology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Syst. Biol."],"abstract":"<jats:p>\n                    Computational modelling is a widely used approach for understanding complex biological systems, enabling researchers to formalise mechanisms, analyse dynamic behaviours, and generate predictive insights across multiple biological scales. The BioModels\n                    <jats:italic>Model of the Year (MOY) 2024<\/jats:italic>\n                    competition was organised to recognise outstanding modelling contributions from the systems biology community, with a particular focus on early-career researchers and models that demonstrate strong scientific impact, technical rigour, and reproducibility. The initiative also promotes best practices in model dissemination by encouraging submissions that follow community standards and adhere to FAIR principles. Here, we describe the MOY2024 selection process and present the four winning models curated in BioModels. The award-winning submissions span diverse areas of biomedical research, including hepatocyte signalling in metabolic liver disease, cardiac electrophysiology for drug safety assessment, multiscale modelling of intestinal epithelial dynamics, and electromechanical modelling of post-infarction cardiomyocytes. Together, these reproducible and reusable systems biology models illustrate how computational frameworks can advance both fundamental biology and translational biomedical research.\n                  <\/jats:p>","DOI":"10.3389\/fsysb.2026.1829848","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:24:32Z","timestamp":1783509872000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["BioModels\u2019 model of the year 2024"],"prefix":"10.3389","volume":"6","author":[{"given":"Rahuman S.","family":"Malik Sheriff","sequence":"first","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton","place":["Cambridge, United Kingdom"]},{"name":"Department of Surgery and Cancer, Imperial College London","place":["London, United Kingdom"]},{"name":"Laboratory for Systems Medicine, Department of Medicine, University of Florida","place":["Gainesville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Asari","sequence":"additional","affiliation":[{"name":"Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)","place":["Monterotondo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbet","family":"Geris","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Mechanical Engineering (Biomechanics Section), Leuven, Belgium; and University of Li\u00e8ge, GIGA In Silico Medicine","place":["Li\u00e8ge, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Hermjakob","sequence":"additional","affiliation":[{"name":"European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Hinxton","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Robert Bosch Centre for Data Science & AI (RBCDSAI), Indian Institute of Technology Madras","place":["Chennai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blerta","family":"Shtylla","sequence":"additional","affiliation":[{"name":"Pharmacometrics & Systems Pharmacology, Translational Clinical Sciences, Pfizer R & D, La Jolla","place":["San Diego, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Zimmermann-Kogadeeva","sequence":"additional","affiliation":[{"name":"Genome Biology Unit, European Molecular Biology Laboratory (EMBL)","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s44320-023-00007-4","article-title":"Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease","volume":"20","author":"Burbano de Lara","year":"2024","journal-title":"Mol. Syst. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e85478","DOI":"10.7554\/eLife.85478","article-title":"Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt","volume":"12","author":"Gall","year":"2023","journal-title":"eLife"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1363884","DOI":"10.3389\/fsysb.2024.1363884","article-title":"BioModels' model of the year 2023","volume":"4","author":"Malik Sheriff","year":"2024","journal-title":"Front. Syst. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"D407","DOI":"10.1093\/nar\/gkz1055","article-title":"BioModels-15 years of sharing computational models in life science","volume":"48","author":"Malik-Sheriff","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"107172","DOI":"10.1016\/j.vascn.2022.107172","article-title":"Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological assay to facilitate early pharmaceutical cardiosafety assessment: dream or reality?","volume":"115","author":"Mohr","year":"2022","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.24.614797","article-title":"FROG analysis ensures the reproducibility of genome-scale metabolic models","author":"Raman","year":"2024","journal-title":"bioRxiv"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-026-00651-0","article-title":"From FAIR to CURE: guidelines for computational models of biological systems","volume":"12","author":"Sauro","year":"2026","journal-title":"Npj Syst. Biol. Appl."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2406.16820","article-title":"EFECT: a method to quantify the reproducibility of stochastic simulations","author":"Sego","year":"2024","journal-title":"arXiv"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e9982","DOI":"10.15252\/msb.20209982","article-title":"Reproducibility in systems biology modelling","volume":"17","author":"Tiwari","year":"2021","journal-title":"Mol. Syst. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"RP93002","DOI":"10.7554\/eLife.93002","article-title":"Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations","volume":"13","author":"Zhou","year":"2024","journal-title":"eLife"}],"container-title":["Frontiers in Systems Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsysb.2026.1829848\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:24:32Z","timestamp":1783509872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsysb.2026.1829848\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":10,"alternative-id":["10.3389\/fsysb.2026.1829848"],"URL":"https:\/\/doi.org\/10.3389\/fsysb.2026.1829848","relation":{},"ISSN":["2674-0702"],"issn-type":[{"value":"2674-0702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"article-number":"1829848"}}