{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:44:04Z","timestamp":1781970244934,"version":"3.54.5"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:p>The stability of drugs can affect drug tests and interpretations. A comprehensive study to verify drug stability in Quantisal<jats:sup>\u00ae<\/jats:sup> oral fluid (OF) collection device was undertaken in accordance with Australian standard, AS\/NZS 4760:2019 (SAI-Global, <jats:xref>2019<\/jats:xref>). The evaluation was performed for the following drugs: (\u00b1) amphetamine, (\u00b1) methylamphetamine, (\u00b1) 3,4-methylenedioxymethylamphetamine (MDMA), (\u2212)\u03949-tetrahydrocannabinol (THC), cocaine, benzoylecgonine, morphine, codeine, and oxycodone. Stability was assessed at four different storage temperatures over seven time points at \u00b150% cut-off concentrations (Appendix A, Para A4-4.1, AS\/NZS 4760:2019) (SAI-Global, <jats:xref>2019<\/jats:xref>). All drugs were found to be significantly more stable at 4 and \u201320\u00b0C, with stability spanning at least 14 days with percentage change within \u00b120% from the cut-off concentrations (SAI-Global, <jats:xref>2019<\/jats:xref>). In addition, we report a variation trend with cocaine and benzoylecgonine at elevated temperatures, suggesting hydrolytic decomposition of cocaine and a concomitant increase in benzoylecgonine quantitative values. We confirm the cross-talk by showing that the percentage change in the profile of average cocaine-benzoylecgonine measurement is within the acceptance concentration range of \u00b120%. This finding highlights the importance of precaution during storage and careful considerations during subsequent interpretation of liquid chromatography-mass spectrometry (LCMS) measurements.<\/jats:p>","DOI":"10.3389\/ftox.2021.670656","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:25:30Z","timestamp":1625473530000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Quantisal\u00ae Oral Fluid Collection Device on Drug Stability"],"prefix":"10.3389","volume":"3","author":[{"given":"Michela","family":"Riggio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur A.","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko","family":"Koscak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Blakey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Appleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"B1","first-page":"1","author":"AAFS Standards Board","year":"2019","journal-title":"Standard Practices for Method Validation in Forensic Toxicology. 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