{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:26:57Z","timestamp":1787952417317,"version":"build-2784847793"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> To report visual function and quality of life (VF\/QOL) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the ocular surface disease index (OSDI) in patients in the chronic phase of Stevens-Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The NEI-VFQ-25 questionnaire was administered to 15 patients who received protocol-based care in the form of topical medications with or without amniotic membrane transplantation (AMT) for acute SJS\/TEN. The scores obtained were compared with scores from a healthy population. The associations between the NEI-VFQ-25 and dry eye symptoms as measured by OSDI questionnaire were also studied.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Patients were surveyed at a mean of 4.47 \u00b1 2.22 years after acute SJS\/TEN. Eleven patients received AMT in the acute phase. The median best corrected visual acuity at the time of administration of the questionnaire was 20\/20. The mean composite NEI-VFQ-25 score was 86.48 \u00b1 12. Patients who received protocol-based treatment in the acute phase of SJS\/TEN had comparable NEI-VFQ-25 scores with healthy subjects on all subscales except ocular pain (<jats:italic>p<\/jats:italic> = 0.027) and mental health (<jats:italic>p<\/jats:italic> = 0.014), which were significantly reduced. The NEI-VFQ-25 composite scores significantly correlated with OSDI (R = -0.75, <jats:italic>p<\/jats:italic> = 0.001).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> A protocol-based management strategy composed of early ophthalmic evaluation, grading based on severity, the use of topical corticosteroids and AMT in the acute phase of SJS\/TEN in patients with ocular complications helped preserve the VF\/QOL. This study highlights the impact of appropriate management of the ocular complications in the acute phase of SJS\/TEN.<\/jats:p>","DOI":"10.3389\/ftox.2022.992696","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:28:37Z","timestamp":1667370517000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Visual function and quality of life in patients with Stevens-Johnson syndrome who received acute protocol-based ocular care"],"prefix":"10.3389","volume":"4","author":[{"given":"Swapna S.","family":"Shanbhag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Tahboub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chodosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajirah N.","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ajo.2018.01.028","article-title":"Chronic ocular sequelae of stevens-johnson syndrome in children: Long-term impact of appropriate Therapy on natural history of disease","volume":"189","author":"Basu","year":"2018","journal-title":"Am. 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