{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:28:04Z","timestamp":1790821684014,"version":"4.1.0"},"reference-count":372,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:p>Aging is a complex biological process involving multiple interacting mechanisms and is being increasingly linked to environmental exposures such as wildfire smoke. In this review, we detail the hallmarks of aging, emphasizing the role of telomere attrition, cellular senescence, epigenetic alterations, proteostasis, genomic instability, and mitochondrial dysfunction, while also exploring integrative hallmarks - altered intercellular communication and stem cell exhaustion. Within each hallmark of aging, our review explores how environmental disasters like wildfires, and their resultant inhaled toxicants, interact with these aging mechanisms. The intersection between aging and environmental exposures, especially high-concentration insults from wildfires, remains under-studied. Preliminary evidence, from our group and others, suggests that inhaled wildfire smoke can accelerate markers of neurological aging and reduce learning capabilities. This is likely mediated by the augmentation of circulatory factors that compromise vascular and blood-brain barrier integrity, induce chronic neuroinflammation, and promote age-associated proteinopathy-related outcomes. Moreover, wildfire smoke may induce a reduced metabolic, senescent cellular phenotype. Future interventions could potentially leverage combined anti-inflammatory and NAD + boosting compounds to counter these effects. This review underscores the critical need to study the intricate interplay between environmental factors and the biological mechanisms of aging to pave the way for effective interventions.<\/jats:p>","DOI":"10.3389\/ftox.2023.1267667","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T09:51:03Z","timestamp":1697017863000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality"],"prefix":"10.3389","volume":"5","author":[{"given":"David","family":"Scieszka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia M.","family":"Bolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Brigman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Campen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/s41388-020-01637-w","article-title":"Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer","volume":"40","author":"Abril","year":"2021","journal-title":"Oncogene"},{"key":"B2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.resp.2014.02.006","article-title":"High altitude exposure alters gene expression levels of DNA repair enzymes, and modulates fatty acid metabolism by SIRT4 induction in human skeletal muscle","volume":"196","author":"Acs","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"33583","DOI":"10.1074\/jbc.M705488200","article-title":"Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase","volume":"282","author":"Ahuja","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.healun.2010.08.010","article-title":"Increased risk of venous thromboembolism with a sirolimus-based immunosuppression regimen in lung transplantation","volume":"30","author":"Ahya","year":"2011","journal-title":"J. Heart Lung Transpl. Off. Publ. Int. Soc. Heart Transpl."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1002\/art.38868","article-title":"FoxO transcription factors support oxidative stress resistance in human chondrocytes","volume":"66","author":"Akasaki","year":"2014","journal-title":"Arthritis Rheumatol. Hob. N. J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e2221529120","DOI":"10.1073\/pnas.2221529120","article-title":"Mammalian telomeric RNA (TERRA) can be translated to produce valine\u2013arginine and glycine\u2013leucine dipeptide repeat proteins","volume":"120","author":"Al-Turki","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s11357-013-9559-2","article-title":"Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study Treviso Longeva (TRELONG)","volume":"36","author":"Albani","year":"2014","journal-title":"Age Dordr. Neth."},{"key":"B8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/gerona\/glr223","article-title":"Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span","volume":"67","author":"Andersen","year":"2012","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1080\/15384101.2016.1189041","article-title":"Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status","volume":"15","author":"Anwar","year":"2016","journal-title":"Cell Cycle georget. Tex"},{"key":"B10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12012-015-9325-z","article-title":"Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures","volume":"16","author":"Aragon","year":"2016","journal-title":"Cardiovasc. Toxicol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"E1968","DOI":"10.1073\/pnas.1616070114","article-title":"Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood-brain barrier impairment","volume":"114","author":"Aragon","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B12","volume-title":"Aristotle\u2019s parva naturalia","year":"2023"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1210\/jc.2015-3754","article-title":"Long-term metformin use and vitamin B12 deficiency in the diabetes prevention program outcomes study","volume":"101","author":"Aroda","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B14","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/gerona\/glv015","article-title":"Are members of long-lived families healthier than their equally long-lived peers? Evidence from the long life family study","volume":"70","author":"Ash","year":"2015","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41420-021-00683-x","article-title":"The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson\u2019s disease is promoted by conserved oxidation sites","volume":"7","author":"Baeken","year":"2021","journal-title":"Cell Death Discov."},{"key":"B16","doi-asserted-by":"publisher","first-page":"643972","DOI":"10.3389\/fphar.2021.643972","article-title":"Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic","volume":"12","author":"Balali-Mood","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e13431","DOI":"10.1111\/acel.13431","article-title":"mTORC2: the other mTOR in autophagy regulation","volume":"20","author":"Ballesteros-\u00c1lvarez","year":"2021","journal-title":"Aging Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/nature11043","article-title":"SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation","volume":"487","author":"Barber","year":"2012","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"790","DOI":"10.3389\/fendo.2018.00790","article-title":"Hallmarks of aging: an autophagic perspective","volume":"9","author":"Barbosa","year":"2019","journal-title":"Front. Endocrinol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.5500\/wjt.v6.i1.183","article-title":"Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation","volume":"6","author":"Baroja-Mazo","year":"2016","journal-title":"World J. Transpl."},{"key":"B21","doi-asserted-by":"publisher","first-page":"19","DOI":"10.5534\/wjmh.180018","article-title":"Growth hormone and aging: updated review","volume":"37","author":"Bartke","year":"2019","journal-title":"World J. Mens. Health"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e3000599","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"ftw060","DOI":"10.1093\/femspd\/ftw060","article-title":"Neutrophil-generated oxidative stress and protein damage in Staphylococcus aureus","volume":"74","author":"Beavers","year":"2016","journal-title":"Pathog. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.taap.2005.01.023","article-title":"Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies","volume":"207","author":"Becker","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"E952","DOI":"10.1073\/pnas.1104969108","article-title":"Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3\/atypical protein kinase C (aPKC) signaling","volume":"108","author":"Beirowski","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B26","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Bell","year":"2011","journal-title":"Nature"},{"key":"B366","doi-asserted-by":"publisher","first-page":"e000212","DOI":"10.1161\/JAHA.113.000212","article-title":"DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments","volume":"2","author":"Bellavia","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"B27","first-page":"988","article-title":"Nucleotide composition of DNA and RNA from somatic tissues of humpback and its changes during spawning","volume":"32","author":"Berdyshev","year":"1967","journal-title":"Biokhimiia Mosc. Russ."},{"key":"B28","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nature05915","article-title":"The complex language of chromatin regulation during transcription","volume":"447","author":"Berger","year":"2007","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s12276-021-00560-8","article-title":"The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling","volume":"53","author":"Bhattarai","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3390\/ijms23031499","article-title":"Genes and longevity of lifespan","volume":"23","author":"Bin-Jumah","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B371","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1097\/EDE.0b013e31824523f0","article-title":"Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort","volume":"23","author":"Bind","year":"2012","journal-title":"Epidemiology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1152\/ajplegacy.1953.175.3.440","article-title":"Time as a factor in postirradiation protection by parabiosis","volume":"175","author":"Binhammer","year":"1953","journal-title":"Am. J. Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/jat.2987","article-title":"Microvesicle-associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells","volume":"35","author":"Bollati","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.taap.2010.01.019","article-title":"Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines","volume":"244","author":"Bolt","year":"","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.toxlet.2010.08.017","article-title":"Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes","volume":"199","author":"Bolt","year":"","journal-title":"Toxicol. Lett."},{"key":"B35","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/jat.1787","article-title":"Autophagy in toxicology: self-consumption in times of stress and plenty","volume":"32","author":"Bolt","year":"2012","journal-title":"J. Appl. Toxicol. JAT"},{"key":"B36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.taap.2012.08.006","article-title":"Arsenite-induced autophagy is associated with proteotoxicity in human lymphoblastoid cells","volume":"264","author":"Bolt","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3956","DOI":"10.1016\/j.celrep.2019.05.095","article-title":"Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3","volume":"27","author":"Borghesan","year":"2019","journal-title":"Cell Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1534\/genetics.166.2.765","article-title":"Rtg2 protein links metabolism and genome stability in yeast longevity","volume":"166","author":"Borghouts","year":"2004","journal-title":"Genetics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/jnc.14462","article-title":"Current concepts in the neuropathogenesis of mucolipidosis type IV","volume":"148","author":"Boudewyn","year":"2019","journal-title":"J. Neurochem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1242\/jcs.064501","article-title":"p53 at a glance","volume":"123","author":"Brady","year":"2010","journal-title":"J. Cell Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3389\/fncel.2015.00167","article-title":"Differential expression of sirtuins in the aging rat brain","volume":"9","author":"Braidy","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1101\/gad.7.4.592","article-title":"Transcriptional silencing in yeast is associated with reduced nucleosome acetylation","volume":"7","author":"Braunstein","year":"1993","journal-title":"Genes Dev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"dvw005","DOI":"10.1093\/eep\/dvw005","article-title":"Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood","volume":"2","author":"Breton","year":"2016","journal-title":"Environ. Epigenetics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.mito.2019.04.001","article-title":"Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression","volume":"46","author":"Breton","year":"2019","journal-title":"Mitochondrion"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1046\/j.1432-1033.2002.02869.x","article-title":"The mitochondrial-lysosomal axis theory of aging","volume":"269","author":"Brunk","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3942","DOI":"10.1096\/fj.201600410RR","article-title":"Who watches the watchmen? Regulation of the expression and activity of sirtuins","volume":"30","author":"Buler","year":"2016","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"e003218","DOI":"10.1161\/JAHA.116.003218","article-title":"Effects of air pollution and blood mitochondrial DNA methylation on markers of heart rate variability","volume":"5","author":"Byun","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"B48","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1743-8977-10-18","article-title":"Effects of airborne pollutants on mitochondrial DNA methylation","volume":"10","author":"Byun","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"B355","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.scitotenv.2017.07.029","article-title":"Exposure to particulate air pollution during early pregnancy is associated with placental DNA methylation","author":"Cai","year":"2017","journal-title":"Sci. Total Environ."},{"key":"B49","doi-asserted-by":"publisher","first-page":"109226","DOI":"10.1016\/j.envres.2020.109226","article-title":"Reduced repressive epigenetic marks, increased DNA damage and Alzheimer\u2019s disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution","volume":"183","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2020","journal-title":"Environ. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"11568","DOI":"10.3390\/ijerph182111568","article-title":"Particulate air pollution and risk of neuropsychiatric outcomes. What we breathe, swallow, and put on our skin matters","volume":"18","author":"Calder\u00f3n-Garcidue\u00f1as","year":"2021","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"B51","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10552-018-1102-4","article-title":"Active and secondhand smoke exposure throughout life and DNA methylation in breast tumors","volume":"30","author":"Callahan","year":"2019","journal-title":"Cancer Causes Control CCC"},{"key":"B52","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/eurheartj\/ehp259","article-title":"Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents","volume":"31","author":"Camici","year":"2010","journal-title":"Eur. Heart J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.3390\/ijms21093090","article-title":"Particulate air pollution, clock gene methylation, and stroke: effects on stroke severity and disability","volume":"21","author":"Cantone","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cmet.2018.01.016","article-title":"The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications","volume":"27","author":"Carrico","year":"2018","journal-title":"Cell Metab."},{"key":"B55","doi-asserted-by":"crossref","first-page":"770","DOI":"10.2307\/3572952","article-title":"Mechanisms of protection against gastrointestinal and hematopoietic radiation lethality by parabiosis","volume":"39","author":"Carroll","year":"1969","journal-title":"Radiat. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1126\/science.156.3777.954","article-title":"Protection through parabiosis against the lethal effects of exposure to large doses of x-rays","volume":"156","author":"Carroll","year":"1967","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nrg.2015.25","article-title":"Mechanisms underlying structural variant formation in genomic disorders","volume":"17","author":"Carvalho","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.cell.2013.04.040","article-title":"Rhythmic modulation of the hematopoietic niche through neutrophil clearance","volume":"153","author":"Casanova-Acebes","year":"2013","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1152\/physrev.00030.2018","article-title":"SIRT6, a mammalian deacylase with multitasking abilities","volume":"100","author":"Chang","year":"2020","journal-title":"Physiol. Rev."},{"key":"B60","doi-asserted-by":"publisher","first-page":"112484","DOI":"10.1016\/j.ecoenv.2021.112484","article-title":"Particulate matter causes telomere shortening and increase in cellular senescence markers in human lung epithelial cells","volume":"222","author":"Chang-Chien","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B61","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/toxsci\/kfs084","article-title":"Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model","volume":"127","author":"Channell","year":"2012","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/toxsci\/kfw073","article-title":"Sirtuin 3 protects against urban particulate matter-induced autophagy in human bronchial epithelial cells","volume":"152","author":"Chen","year":"2016","journal-title":"Toxicol. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/cvr\/cvab161","article-title":"Senescence mechanisms and targets in the heart","volume":"118","author":"Chen","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"017007","DOI":"10.1289\/EHP1447","article-title":"Fine particulate air pollution and the expression of microRNAs and circulating cytokines relevant to inflammation, coagulation, and vasoconstriction","volume":"126","author":"Chen","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"B65","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4161\/isl.1.3.9262","article-title":"Heavy metals, islet function and diabetes development","volume":"1","author":"Chen","year":"2009","journal-title":"Islets"},{"key":"B66","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cmet.2015.10.013","article-title":"Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges","volume":"23","author":"Cheng","year":"2016","journal-title":"Cell Metab."},{"key":"B67","doi-asserted-by":"publisher","first-page":"104694","DOI":"10.1016\/j.neuint.2020.104694","article-title":"Impairment of mitochondrial function by particulate matter: implications for the brain","volume":"135","author":"Chew","year":"","journal-title":"Neurochem. Int."},{"key":"B68","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12989-020-00352-4","article-title":"Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells","volume":"17","author":"Chew","year":"","journal-title":"Part. Fibre Toxicol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12940-016-0202-4","article-title":"Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the multi-ethnic study of atherosclerosis (MESA)","volume":"15","author":"Chi","year":"2016","journal-title":"Environ. Health Glob. Access Sci. Source"},{"key":"B70","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/joim.12029","article-title":"Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson\u2019s disease?","volume":"273","author":"Chinta","year":"2013","journal-title":"J. Intern. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson\u2019s disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3390\/ijms18040771","article-title":"Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology","volume":"18","author":"Chong","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.3390\/nu11122923","article-title":"The effects of calorie restriction on autophagy: role on aging intervention","volume":"11","author":"Chung","year":"2019","journal-title":"Nutrients"},{"key":"B75","doi-asserted-by":"publisher","first-page":"67005","DOI":"10.1289\/EHP10498","article-title":"Short-term exposure to wildfire smoke and PM2.5 and cognitive performance in a brain-training game: A longitudinal study of U.S. Adults","volume":"130","author":"Cleland","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"B76","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1289\/EHP241","article-title":"Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA normative aging study","volume":"125","author":"Colicino","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"B77","article-title":"Lysosomes","volume-title":"The cell: A molecular approach","author":"Cooper","year":"2000"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLOS Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/EDE.0b013e3182770237","article-title":"The effect of air pollution control on life expectancy in the United States: an analysis of 545 US counties for the period 2000 to 2007","volume":"24","author":"Correia","year":"2013","journal-title":"Epidemiol. Camb. Mass"},{"key":"B80","doi-asserted-by":"publisher","first-page":"11172","DOI":"10.1021\/acs.est.2c02765","article-title":"Outside the safe operating space of a new planetary boundary for per- and polyfluoroalkyl substances (PFAS)","volume":"56","author":"Cousins","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cell.2004.08.020","article-title":"Histone deimination antagonizes arginine methylation","volume":"118","author":"Cuthbert","year":"2004","journal-title":"Cell"},{"key":"B82","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.tplants.2016.04.004","article-title":"The role of MAPK modules and ABA during abiotic stress signaling","volume":"21","author":"de Zelicourt","year":"2016","journal-title":"Trends Plant Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"153049","DOI":"10.1016\/j.tox.2021.153049","article-title":"Environmental factors modulating protein conformations and their role in protein aggregation diseases","volume":"465","author":"Devi","year":"2022","journal-title":"Toxicology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/jpm11020069","article-title":"Proteotoxicity: A fatal consequence of environmental pollutants-induced impairments in protein clearance machinery","volume":"11","author":"Devi","year":"2021","journal-title":"J. Pers. Med."},{"key":"B85","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41386-019-0503-8","article-title":"Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model","volume":"45","author":"Diaz-Perdigon","year":"2020","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"43737","DOI":"10.1038\/srep43737","article-title":"Dose- and time-effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution","volume":"7","author":"Ding","year":"2017","journal-title":"Sci. Rep."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1007\/s00018-008-7581-9","article-title":"The comparative biology of neuromelanin and lipofuscin in the human brain","volume":"65","author":"Double","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"B88","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Science"},{"key":"B89","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/toxics10010013","article-title":"Prenatal PM2.5 exposure in relation to maternal and newborn telomere length at delivery","volume":"10","author":"Durham","year":"2022","journal-title":"Toxics"},{"key":"B90","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s40572-021-00328-2","article-title":"Environmental exposures and lung aging: molecular mechanisms and implications for improving respiratory health","volume":"8","author":"Eckhardt","year":"2021","journal-title":"Curr. Environ. Health Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/j.bbadis.2018.11.014","article-title":"Acetylation as a major determinant to microtubule-dependent autophagy: relevance to Alzheimer\u2019s and Parkinson disease pathology","volume":"1865","author":"Esteves","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B93","doi-asserted-by":"publisher","first-page":"67003","DOI":"10.1289\/EHP6174","article-title":"Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study","volume":"128","author":"Eze","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"B94","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s13353-010-0007-z","article-title":"Frequency of double minute chromosomes and combined cytogenetic abnormalities and their characteristics","volume":"52","author":"Fan","year":"2011","journal-title":"J. Appl. Genet."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.tma.2019.12.001","article-title":"Automation of C. elegans lifespan measurement","volume":"4","author":"Felker","year":"2020","journal-title":"Transl. Med. Aging"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1002\/tox.22202","article-title":"Regulation of ozone-induced lung inflammation by the epidermal growth factor receptor in mice","volume":"31","author":"Feng","year":"2016","journal-title":"Environ. Toxicol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1177\/1947601911410223","article-title":"The regulation of aging and longevity: A new and complex role of p53","volume":"2","author":"Feng","year":"2011","journal-title":"Genes Cancer"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13148-019-0726-x","article-title":"Particulate matter exposure shapes DNA methylation through the lifespan","volume":"11","author":"Ferrari","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1038\/s41467-017-02183-y","article-title":"Identification and characterization of two functional variants in the human longevity gene FOXO3","volume":"8","author":"Flachsbart","year":"2017","journal-title":"Nat. Commun."},{"key":"B368","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.exger.2018.05.018","article-title":"Influence of aging in the modulation of epigenetic biomarkers of carcinogenesis after exposure to air pollution","volume":"110","author":"Fougere","year":"2018","journal-title":"Exp. Gerontol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1016\/j.neuint.2012.07.010","article-title":"SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition","volume":"61","author":"Gal","year":"2012","journal-title":"Neurochem. Int."},{"key":"B101","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.med.59.061606.095816","article-title":"Cancer epigenetics: modifications, screening, and therapy","volume":"59","author":"Gal-Yam","year":"2008","journal-title":"Annu. Rev. Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"101545","DOI":"10.1016\/j.redox.2020.101545","article-title":"Oxidative stress pathways of air pollution mediated toxicity: recent insights","volume":"34","author":"Gangwar","year":"2020","journal-title":"Redox Biol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.molcel.2009.07.012","article-title":"The effect of replication initiation on gene amplification in the rDNA and its relationship to aging","volume":"35","author":"Ganley","year":"2009","journal-title":"Mol. Cell"},{"key":"B104","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1089\/rej.2016.1883","article-title":"Antiaging effect of metformin on brain in naturally aged and accelerated senescence model of rat","volume":"20","author":"Garg","year":"2017","journal-title":"Rejuvenation Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"e226257","DOI":"10.1001\/jamanetworkopen.2022.6257","article-title":"Effect of plasma and blood donations on levels of perfluoroalkyl and polyfluoroalkyl substances in firefighters in Australia: A randomized clinical trial","volume":"5","author":"Gasiorowski","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"B106","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s10522-013-9478-8","article-title":"SIRT6, a protein with many faces","volume":"14","author":"Gertler","year":"2013","journal-title":"Biogerontology"},{"key":"B107","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.nbd.2010.09.016","article-title":"Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism","volume":"41","author":"Glorioso","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B108","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2007.02.006","article-title":"Epigenetics: a landscape takes shape","volume":"128","author":"Goldberg","year":"2007","journal-title":"Cell"},{"key":"B363","doi-asserted-by":"publisher","first-page":"104723","DOI":"10.1016\/j.envint.2019.03.071","article-title":"Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation","volume":"132","author":"Gondalia","year":"2019","journal-title":"Environ. Int."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-020-01118-6","article-title":"Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes","volume":"3","author":"Gonzalez-Rivera","year":"2020","journal-title":"Commun. Biol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12989-019-0301-9","article-title":"In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation","volume":"16","author":"Goodson","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s10522-017-9685-9","article-title":"Sirtuins, a promising target in slowing down the ageing process","volume":"18","author":"Grabowska","year":"2017","journal-title":"Biogerontology"},{"key":"B112","doi-asserted-by":"publisher","first-page":"re1","DOI":"10.1126\/sageke.2005.5.re1","article-title":"Lipofuscin and aging: A matter of toxic waste","volume":"2005","author":"Gray","year":"2005","journal-title":"Sci. Aging Knowl. Environ."},{"key":"B113","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12940-016-0095-2","article-title":"Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs","volume":"15","author":"Grevendonk","year":"2016","journal-title":"Environ. Health"},{"key":"B114","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nri.2016.62","article-title":"The unfolded protein response in immunity and inflammation","volume":"16","author":"Grootjans","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"57012","DOI":"10.1289\/EHP4522","article-title":"Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis","volume":"127","author":"Gruzieva","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.3390\/cells11121977","article-title":"Age-related lysosomal dysfunctions","volume":"11","author":"Guerrero-Navarro","year":"2022","journal-title":"Cells"},{"key":"B117","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3233\/JAD-200377","article-title":"Air pollution neurotoxicity in the adult brain: emerging concepts from experimental findings","volume":"76","author":"Haghani","year":"2020","journal-title":"J. Alzheimers Dis. Jad."},{"key":"B118","doi-asserted-by":"publisher","first-page":"e6641","DOI":"10.1371\/journal.pone.0006641","article-title":"Genetic variation in healthy oldest-old","volume":"4","author":"Halaschek-Wiener","year":"2009","journal-title":"PloS One"},{"key":"B119","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ejcb.2009.11.006","article-title":"SIRT2-mediated protein deacetylation: an emerging key regulator in brain physiology and pathology","volume":"89","author":"Harting","year":"2010","journal-title":"Eur. J. Cell Biol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"15510","DOI":"10.1038\/s41598-021-94185-6","article-title":"Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells","volume":"11","author":"Haschler","year":"2021","journal-title":"Sci. Rep."},{"key":"B121","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1002\/jnr.21921","article-title":"Cyclophilin D is expressed predominantly in mitochondria of gamma-aminobutyric acidergic interneurons","volume":"87","author":"Hazelton","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1046\/j.1365-2443.1999.00288.x","article-title":"Bloom\u2019s syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast","volume":"4","author":"Heo","year":"1999","journal-title":"Genes Cells Devoted Mol. Cell. Mech."},{"key":"B124","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/BF02185763","article-title":"The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900","volume":"97","author":"Herskind","year":"1996","journal-title":"Hum. Genet."},{"key":"B125","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.neuron.2014.01.028","article-title":"SIRT1 in neurodevelopment and brain senescence","volume":"81","author":"Herskovits","year":"2014","journal-title":"Neuron"},{"key":"B126","doi-asserted-by":"publisher","first-page":"9186","DOI":"10.3390\/ijms21239186","article-title":"Mechanistic insights into the role of molecular chaperones in protein misfolding diseases: from molecular recognition to amyloid disassembly","volume":"21","author":"Herv\u00e1s","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B369","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1080\/15592294.2017.1356555","article-title":"Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion","volume":"12","author":"Hesselbach","year":"2017","journal-title":"Epigenetics"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/sj.bjc.6603671","article-title":"Telomere and telomerase in stem cells","volume":"96","author":"Hiyama","year":"2007","journal-title":"Br. J. Cancer"},{"key":"B128","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.1469-185x.1986.tb00658.x","article-title":"The experimental manipulation of ageing by diet","volume":"61","author":"Holehan","year":"1986","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"B129","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0531-5565(71)90054-4","article-title":"Increase of cholesterol turnover of old rats connected by parabiosis with young rats","volume":"6","author":"Hr\u016fza","year":"1971","journal-title":"Exp. Gerontol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/20694","article-title":"Signals from the reproductive system regulate the lifespan of C. elegans","volume":"399","author":"Hsin","year":"1999","journal-title":"Nature"},{"key":"B131","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40659-022-00379-1","article-title":"A\u03b2 promotes CD38 expression in senescent microglia in Alzheimer\u2019s disease","volume":"55","author":"Hu","year":"2022","journal-title":"Biol. Res."},{"key":"B132","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fgene.2018.00059","article-title":"Age- and tissue-specific expression of senescence biomarkers in mice","volume":"9","author":"Hudgins","year":"2018","journal-title":"Front. Genet."},{"key":"B133","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00294-020-01069-9","article-title":"The adaptive potential of circular DNA accumulation in ageing cells","volume":"66","author":"Hull","year":"2020","journal-title":"Curr. Genet."},{"key":"B134","doi-asserted-by":"publisher","first-page":"e3000471","DOI":"10.1371\/journal.pbio.3000471","article-title":"Transcription-induced formation of extrachromosomal DNA during yeast ageing","volume":"17","author":"Hull","year":"2019","journal-title":"PLoS Biol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1111\/febs.12810","article-title":"SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors","volume":"281","author":"Inoue","year":"2014","journal-title":"FEBS J."},{"key":"B136","doi-asserted-by":"publisher","first-page":"647643","DOI":"10.3389\/fncel.2021.647643","article-title":"The air we breathe: air pollution as a prevalent proinflammatory stimulus contributing to neurodegeneration","volume":"15","author":"Jankowska-Kieltyka","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1743-8977-10-22","article-title":"Placental DNA hypomethylation in association with particulate air pollution in early life","volume":"10","author":"Janssen","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nature09603","article-title":"Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice","volume":"469","author":"Jaskelioff","year":"2011","journal-title":"Nature"},{"key":"B139","doi-asserted-by":"publisher","first-page":"35391","DOI":"10.1038\/srep35391","article-title":"Application of targeted mass spectrometry for the quantification of sirtuins in the central nervous system","volume":"6","author":"Jayasena","year":"2016","journal-title":"Sci. Rep."},{"key":"B140","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature12038","article-title":"SIRT6 regulates TNF-\u03b1 secretion through hydrolysis of long-chain fatty acyl lysine","volume":"496","author":"Jiang","year":"2013","journal-title":"Nature"},{"key":"B141","doi-asserted-by":"publisher","first-page":"e12686","DOI":"10.1111\/jpi.12686","article-title":"Melatonin ameliorates PM2.5 -induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis","volume":"70","author":"Jiang","year":"2021","journal-title":"J. Pineal Res."},{"key":"B142","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"B143","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The epigenomics of cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell"},{"key":"B361","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12931-017-0550-9","article-title":"Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children","volume":"18","author":"Jung","year":"2017","journal-title":"Respir. Res."},{"key":"B144","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.mad.2004.10.007","article-title":"Genes determining yeast replicative life span in a long-lived genetic background","volume":"126","author":"Kaeberlein","year":"2005","journal-title":"Mech. Ageing Dev."},{"key":"B145","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1126\/science.aam9309","article-title":"Quantitative analysis of population-scale family trees with millions of relatives","volume":"360","author":"Kaplanis","year":"2018","journal-title":"Science"},{"key":"B146","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.3390\/ijms22094834","article-title":"p16-3MR: A novel model to study cellular senescence in cigarette smoke-induced lung injuries","volume":"22","author":"Kaur","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2008.10.052","article-title":"SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span","volume":"136","author":"Kawahara","year":"2009","journal-title":"Cell"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41380-022-01680-x","article-title":"Targeting the \u201challmarks of aging\u201d to slow aging and treat age-related disease: fact or fiction?","volume":"2022","author":"Keshavarz","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B149","doi-asserted-by":"publisher","first-page":"200146","DOI":"10.1098\/rsob.200146","article-title":"The proteostatic effects of traffic-derived air pollution on Alzheimer\u2019s disease risk","volume":"10","author":"Kikis","year":"2020","journal-title":"Open Biol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1007\/s11357-022-00645-w","article-title":"Old plasma dilution reduces human biological age: a clinical study","volume":"44","author":"Kim","year":"2022","journal-title":"GeroScience"},{"key":"B151","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1091\/mbc.10.10.3125","article-title":"Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae","volume":"10","author":"Kim","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"B356","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.envint.2016.03.020","article-title":"Maternal residential proximity to major roadways, birth weight, and placental DNA methylation","author":"Kingsley","year":"2016","journal-title":"Environ. Int."},{"key":"B152","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1289\/ehp.1002784","article-title":"Acute decreases in proteasome pathway activity after inhalation of fresh diesel exhaust or secondary organic aerosol","volume":"119","author":"Kipen","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"B153","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s10522-013-9443-6","article-title":"Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats","volume":"14","author":"Kireev","year":"2013","journal-title":"Biogerontology"},{"key":"B154","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1266\/ggs.81.155","article-title":"Strategies to maintain the stability of the ribosomal RNA gene repeats","volume":"81","author":"Kobayashi","year":"2006","journal-title":"Genes Genet. Syst."},{"key":"B155","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s43032-021-00461-1","article-title":"Control of LINE-1 expression maintains genome integrity in germline and early embryo development","volume":"29","author":"Kohlrausch","year":"2022","journal-title":"Reprod. Sci."},{"key":"B156","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1111\/febs.12326","article-title":"Telomere shortening in human diseases","volume":"280","author":"Kong","year":"2013","journal-title":"FEBS J."},{"key":"B157","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.redox.2017.01.017","article-title":"Mitochondrial contribution to lipofuscin formation","volume":"11","author":"K\u00f6nig","year":"2017","journal-title":"Redox Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"8019","DOI":"10.1093\/nar\/gkz518","article-title":"Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair","volume":"47","author":"Korsholm","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tibs.2013.12.002","article-title":"Chromatin and beyond: the multitasking roles for SIRT6","volume":"39","author":"Kugel","year":"2014","journal-title":"Trends biochem. Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1161\/HYPERTENSIONAHA.118.12378","article-title":"Therapeutic suppression of mTOR (mammalian target of rapamycin) signaling prevents and reverses salt-induced hypertension and kidney injury in dahl salt-sensitive rats","volume":"73","author":"Kumar","year":"2019","journal-title":"Hypertension"},{"key":"B161","doi-asserted-by":"publisher","first-page":"e1003329","DOI":"10.1371\/journal.pgen.1003329","article-title":"A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan","volume":"9","author":"Kwan","year":"2013","journal-title":"PLoS Genet."},{"key":"B162","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1084\/jem.13.2.257","article-title":"The influence of mouse-rat parabiosis on the growth in rats of A transplantable mouse sarcoma","volume":"13","author":"Lambert","year":"1911","journal-title":"J. Exp. Med."},{"key":"B163","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1093\/carcin\/bgv031","article-title":"Causes of genome instability: the effect of low dose chemical exposures in modern society","volume":"36","author":"Langie","year":"2015","journal-title":"Carcinogenesis"},{"key":"B164","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.envpol.2017.06.028","article-title":"Genetic and epigenetic alterations in normal and sensitive COPD-diseased human bronchial epithelial cells repeatedly exposed to air pollution-derived PM2.5","volume":"230","author":"Leclercq","year":"2017","journal-title":"Environ. Pollut. Barking Essex"},{"key":"B165","doi-asserted-by":"publisher","first-page":"109707","DOI":"10.1016\/j.envres.2020.109707","article-title":"Prenatal particulate air pollution and newborn telomere length: effect modification by maternal antioxidant intakes and infant sex","volume":"187","author":"Lee","year":"2020","journal-title":"Environ. Res."},{"key":"B166","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1474-9726.2006.00241.x","article-title":"Dietary deprivation extends lifespan in Caenorhabditis elegans","volume":"5","author":"Lee","year":"2006","journal-title":"Aging Cell"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1038\/s41591-019-0673-2","article-title":"Undulating changes in human plasma proteome profiles across the lifespan","volume":"25","author":"Lehallier","year":"2019","journal-title":"Nat. Med."},{"key":"B168","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nm0106-34","article-title":"Sirt1: a metabolic master switch that modulates lifespan","volume":"12","author":"Leibiger","year":"2006","journal-title":"Nat. Med."},{"key":"B169","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1111\/brv.12328","article-title":"Reproductive senescence: new perspectives in the wild","volume":"92","author":"Lema\u00eetre","year":"2017","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"B170","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.envint.2018.07.041","article-title":"Short-term exposure to fine particulate air pollution and genome-wide DNA methylation: A randomized, double-blind, crossover trial","volume":"120","author":"Li","year":"2018","journal-title":"Environ. Int."},{"key":"B171","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/crj.12389","article-title":"Particulate matter-induced epigenetic changes and lung cancer","volume":"11","author":"Li","year":"2017","journal-title":"Clin. Respir. J."},{"key":"B172","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1021\/tx5003723","article-title":"Effect of ambient PM2.5 on lung mitochondrial damage and fusion\/fission gene expression in rats","volume":"28","author":"Li","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"116601","DOI":"10.1016\/j.envpol.2021.116601","article-title":"Short-term personal PM2.5 exposure and change in DNA methylation of imprinted genes: panel study of healthy young adults in guangzhou city, China","volume":"275","author":"Liang","year":"2021","journal-title":"Environ. Pollut. Barking Essex"},{"key":"B174","doi-asserted-by":"publisher","first-page":"21313","DOI":"10.1074\/jbc.M413296200","article-title":"Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase","volume":"280","author":"Liszt","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12940-015-0052-5","article-title":"Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature","volume":"14","author":"Liu","year":"2015","journal-title":"Environ. Health Glob. Access Sci. Source"},{"key":"B176","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1089\/ars.2016.6662","article-title":"Loss of NAD-dependent protein deacetylase sirtuin-2 alters mitochondrial protein acetylation and dysregulates mitophagy","volume":"26","author":"Liu","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"B177","doi-asserted-by":"publisher","first-page":"487074","DOI":"10.1155\/2011\/487074","article-title":"Oxidative stress and air pollution exposure","volume":"2011","author":"Lodovici","year":"2011","journal-title":"J. Toxicol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"B180","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.cell.2016.07.031","article-title":"Metabolic control of longevity","volume":"166","author":"L\u00f3pez-Ot\u00edn","year":"2016","journal-title":"Cell"},{"key":"B181","doi-asserted-by":"publisher","first-page":"10699","DOI":"10.1007\/s13277-014-2372-4","article-title":"SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer","volume":"35","author":"Lu","year":"2014","journal-title":"Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med."},{"key":"B182","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.2164-0947.1972.tb02712.x","article-title":"Mortality in syngeneic rat parabionts of different chronological age*\u2020","volume":"34","author":"Ludwig","year":"1972","journal-title":"Trans. N. Y. Acad. Sci."},{"key":"B183","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s12017-014-8288-8","article-title":"Distinct patterns of sirtuin expression during progression of Alzheimer\u2019s disease","volume":"16","author":"Lutz","year":"2014","journal-title":"Neuromolecular Med."},{"key":"B184","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.18632\/aging.102735","article-title":"Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors","volume":"12","author":"Ma","year":"2020","journal-title":"Aging"},{"key":"B372","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/aje\/kwr523","article-title":"Air pollution and DNA methylation: interaction by psychological factors in the VA Normative Aging Study","volume":"176","author":"Madrigano","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"e0199772","DOI":"10.1371\/journal.pone.0199772","article-title":"Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation","volume":"13","author":"Maghbooli","year":"2018","journal-title":"PloS One"},{"key":"B186","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00467-007-0527-x","article-title":"Growth hormone axis in chronic kidney disease","volume":"23","author":"Mahesh","year":"2008","journal-title":"Pediatr. Nephrol. Berl. Ger."},{"key":"B187","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/jcm10010077","article-title":"Air pollution\u2014an overlooked risk factor for idiopathic pulmonary fibrosis","volume":"10","author":"Majewski","year":"2020","journal-title":"J. Clin. Med."},{"key":"B188","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1126\/science.1202723","article-title":"SIRT6 promotes DNA repair under stress by activating PARP1","volume":"332","author":"Mao","year":"2011","journal-title":"Science"},{"key":"B189","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.cell.2017.07.049","article-title":"SnapShot: cellular senescence pathways","volume":"170","author":"Mart\u00ednez-Zamudio","year":"2017","journal-title":"Cell"},{"key":"B190","doi-asserted-by":"publisher","first-page":"17383","DOI":"10.1073\/pnas.1900055116","article-title":"Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis","volume":"116","author":"Matai","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"14063","DOI":"10.1038\/ncomms14063","article-title":"Caloric restriction improves health and survival of rhesus monkeys","volume":"8","author":"Mattison","year":"2017","journal-title":"Nat. Commun."},{"key":"B192","doi-asserted-by":"publisher","first-page":"3986","DOI":"10.1093\/hmg\/ddr326","article-title":"The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS","volume":"20","author":"Maxwell","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B193","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.1128\/MCB.22.12.4136-4146.2002","article-title":"Mutations in DNA replication genes reduce yeast life span","volume":"22","author":"Mays Hoopes","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000210677","article-title":"Parabiosis between old and young rats","volume":"1","author":"Mccay","year":"1957","journal-title":"Gerontologia"},{"key":"B195","doi-asserted-by":"publisher","first-page":"110888","DOI":"10.1016\/j.exger.2020.110888","article-title":"Age-related NAD+ decline","volume":"134","author":"McReynolds","year":"2020","journal-title":"Exp. Gerontol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1021\/acs.chemrestox.8b00352","article-title":"Inorganic arsenic as an endocrine disruptor: modulation of the glucocorticoid receptor pathway in placental cells via CpG methylation","volume":"32","author":"Meakin","year":"2019","journal-title":"Chem. Res. Toxicol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.toxlet.2021.07.008","article-title":"Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors","volume":"350","author":"Medina","year":"2021","journal-title":"Toxicol. Lett."},{"key":"B198","doi-asserted-by":"publisher","first-page":"115155","DOI":"10.1016\/j.taap.2020.115155","article-title":"Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice","volume":"403","author":"Medina","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.toxlet.2017.03.021","article-title":"Low level arsenite exposures suppress the development of bone marrow erythroid progenitors and result in anemia in adult male mice","volume":"273","author":"Medina","year":"2017","journal-title":"Toxicol. Lett."},{"key":"B200","doi-asserted-by":"publisher","first-page":"116193","DOI":"10.1016\/j.taap.2022.116193","article-title":"Arsenic impairs the lineage commitment of hematopoietic progenitor cells through the attenuation of GATA-2 DNA binding activity","volume":"452","author":"Medina","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11357-020-00297-8","article-title":"Plasma dilution improves cognition and attenuates neuroinflammation in old mice","volume":"43","author":"Mehdipour","year":"2021","journal-title":"GeroScience"},{"key":"B202","doi-asserted-by":"publisher","first-page":"8790","DOI":"10.18632\/aging.103418","article-title":"Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin","volume":"12","author":"Mehdipour","year":"2020","journal-title":"Aging"},{"key":"B203","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cytogfr.2017.11.001","article-title":"Nuclear sirtuins and inflammatory signaling pathways","volume":"38","author":"Mendes","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"B204","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1128\/MCB.22.2.421-429.2002","article-title":"hpr1\u0394 affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae","volume":"22","author":"Merker","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"B205","volume-title":"LiverTox: Clinical and research information on drug-induced liver injury","year":"2012"},{"key":"B206","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/nature06736","article-title":"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin","volume":"452","author":"Michishita","year":"2008","journal-title":"Nature"},{"key":"B207","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1080\/08958378.2018.1483984","article-title":"Acute inhalation of ozone induces DNA methylation of apelin in lungs of Long-Evans rats","volume":"30","author":"Miller","year":"2018","journal-title":"Inhal. Toxicol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.cmet.2016.05.014","article-title":"The somatotropic Axis in human aging: framework for the current state of knowledge and future research","volume":"23","author":"Milman","year":"2016","journal-title":"Cell Metab."},{"key":"B209","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-3-7091-1001-0_2","article-title":"Brain changes in iron loading disorders","volume-title":"Metal ions in neurological systems","author":"Milward","year":"2012"},{"key":"B210","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3389\/fendo.2018.00783","article-title":"The roles of mitochondrial SIRT4 in cellular metabolism","volume":"9","author":"Min","year":"2019","journal-title":"Front. Endocrinol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.envint.2017.12.017","article-title":"Environmental arsenic exposure: from genetic susceptibility to pathogenesis","volume":"112","author":"Minatel","year":"2018","journal-title":"Environ. Int."},{"key":"B212","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.taap.2011.09.007","article-title":"The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter","volume":"257","author":"Miyata","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/s41467-018-03369-8","article-title":"Circular DNA elements of chromosomal origin are common in healthy human somatic tissue","volume":"9","author":"M\u00f8ller","year":"2018","journal-title":"Nat. Commun."},{"key":"B214","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1111\/resp.12112","article-title":"Adult stem cells for chronic lung diseases","volume":"18","author":"Mora","year":"2013","journal-title":"Respirol. Carlt. Vic."},{"key":"B215","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12989-019-0304-6","article-title":"Nanoparticle exposure driven circulating bioactive peptidome causes systemic inflammation and vascular dysfunction","volume":"16","author":"Mostovenko","year":"2019","journal-title":"Part. Fibre Toxicol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.envres.2016.01.010","article-title":"MicroRNAs are associated with blood-pressure effects of exposure to particulate matter: results from a mediated moderation analysis","volume":"146","author":"Motta","year":"2016","journal-title":"Environ. Res."},{"key":"B217","doi-asserted-by":"publisher","first-page":"55981","DOI":"10.1007\/s11356-021-16056-x","article-title":"Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis","volume":"28","author":"Mukherjee","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"B218","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1096\/fj.201500047","article-title":"Microglial priming through the lung-brain axis: the role of air pollution-induced circulating factors","volume":"30","author":"Mumaw","year":"2016","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1242\/jcs.081067","article-title":"Sirtuins at a glance","volume":"124","author":"Nakagawa","year":"2011","journal-title":"J. Cell Sci."},{"key":"B220","doi-asserted-by":"publisher","first-page":"31995","DOI":"10.1074\/jbc.M110.124164","article-title":"SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells","volume":"285","author":"Nasrin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B221","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1101\/gad.1404206","article-title":"Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications","volume":"20","author":"Nathan","year":"2006","journal-title":"Genes Dev."},{"key":"B359","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.envint.2018.02.034","article-title":"Placental circadian pathway methylation and in utero exposure to fine particle air pollution","volume":"114","author":"Nawrot","year":"2018","journal-title":"Environ. Int."},{"key":"B222","volume-title":"Definition of genomic instability - NCI dictionary of cancer terms - NCI","year":"2011"},{"key":"B223","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.cell.2006.07.026","article-title":"Proline isomerization of histone H3 regulates lysine methylation and gene expression","volume":"126","author":"Nelson","year":"2006","journal-title":"Cell"},{"key":"B224","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1101\/gad.205062.112","article-title":"Alternative lengthening of telomeres in normal mammalian somatic cells","volume":"27","author":"Neumann","year":"2013","journal-title":"Genes Dev."},{"key":"B358","doi-asserted-by":"publisher","first-page":"e174","DOI":"10.1016\/S2542-5196(18)30049-4","article-title":"Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIRONAGE cohort study","volume":"2","author":"Neven","year":"2018","journal-title":"Lancet Planet Health"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00064","article-title":"SIRT1 in the brain\u2014Connections with aging-associated disorders and lifespan","volume":"9","author":"Ng","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B226","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/s1097-2765(03)00038-8","article-title":"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase","volume":"11","author":"North","year":"2003","journal-title":"Mol. Cell"},{"key":"B227","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.tig.2004.02.007","article-title":"Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation","volume":"20","author":"Nowak","year":"2004","journal-title":"Trends Genet. TIG"},{"key":"B228","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.exger.2014.04.018","article-title":"Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals","author":"Nygaard","year":"2014","journal-title":"Exp. Gerontol."},{"key":"B357","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.jaci.2013.09.007","article-title":"The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease","volume":"132","author":"Oakley","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"e13296","DOI":"10.1111\/acel.13296","article-title":"Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice","volume":"20","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"key":"B230","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0014-5793(99)00748-6","article-title":"Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening","volume":"453","author":"Oikawa","year":"1999","journal-title":"FEBS Lett."},{"key":"B231","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0022-5193(73)90198-7","article-title":"A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon","volume":"41","author":"Olovnikov","year":"1973","journal-title":"J. Theor. Biol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.2337\/db14-1820","article-title":"Cellular senescence in type 2 diabetes: A therapeutic opportunity","volume":"64","author":"Palmer","year":"2015","journal-title":"Diabetes"},{"key":"B370","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1289\/ehp.1509966","article-title":"Genome-wide analysis of DNA methylation and fine particulate matter air pollution in three study populations: KORA F3, KORA F4, and the Normative Aging Study","volume":"124","author":"Panni","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"B233","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.3390\/ijms19092727","article-title":"Air pollution, autophagy, and skin aging: impact of particulate matter (PM10) on human dermal fibroblasts","volume":"19","author":"Park","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2022.822397","article-title":"Oral senescence: from molecular biology to clinical research","volume":"3","author":"Parkinson","year":"2022","journal-title":"Front. Dent. Med."},{"key":"B235","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.taap.2017.05.014","article-title":"Arsenic exposures alter clinical indicators of anemia in a male population of smokers and non-smokers in Bangladesh","volume":"331","author":"Parvez","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B236","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/gerona\/glw159","article-title":"The survival of spouses marrying into longevity-enriched families","volume":"72","author":"Pedersen","year":"2017","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"B237","doi-asserted-by":"publisher","first-page":"270","DOI":"10.5009\/gnl.2013.7.3.270","article-title":"The role of cellular senescence in the gastrointestinal mucosa","volume":"7","author":"Penfield","year":"2013","journal-title":"Gut Liver"},{"key":"B238","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1016\/j.cell.2021.01.043","article-title":"Hallmarks of environmental insults","volume":"184","author":"Peters","year":"2021","journal-title":"Cell"},{"key":"B239","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1289\/ehp.1509728","article-title":"Biomolecular markers within the core Axis of aging and particulate air pollution exposure in the elderly: A cross-sectional study","volume":"124","author":"Pieters","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"B240","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s42003-018-0024-8","article-title":"Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates","volume":"1","author":"Pifferi","year":"2018","journal-title":"Commun. Biol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"e10488","DOI":"10.1002\/jbm4.10488","article-title":"Bone aging, cellular senescence, and osteoporosis","volume":"5","author":"Pignolo","year":"2021","journal-title":"JBMR Plus"},{"key":"B242","doi-asserted-by":"publisher","first-page":"e0163046","DOI":"10.1371\/journal.pone.0163046","article-title":"Endoplasmic reticulum stress links oxidative stress to impaired pancreatic beta-cell function caused by human oxidized LDL","volume":"11","author":"Plaisance","year":"2016","journal-title":"PloS One"},{"key":"B243","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s40572-018-0182-3","article-title":"Heavy metal exposure and metabolic syndrome: evidence from human and model system studies","volume":"5","author":"Planchart","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"B365","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.envint.2017.08.006","article-title":"DNA methylation and exposure to ambient air pollution in two prospective cohorts","volume":"108","author":"Plusquin","year":"2017","journal-title":"Environ. Int."},{"key":"B244","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41583-019-0255-9","article-title":"Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration","volume":"21","author":"Pluvinage","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"B245","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1056\/NEJMsa0805646","article-title":"Fine particulate air pollution and US county life expectancies","volume":"360","author":"Pope","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"B360","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13148-017-0433-4","article-title":"Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma","volume":"10","author":"Prunicki","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"B246","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1042\/EBC20170027","article-title":"mTORC1 as the main gateway to autophagy","volume":"61","author":"Rabanal-Ruiz","year":"2017","journal-title":"Essays Biochem."},{"key":"B247","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/febs.16649","article-title":"Senescent cells in the brain and where to find them","volume":"290","author":"Rachmian","year":"2023","journal-title":"FEBS J."},{"key":"B248","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1089\/ars.2017.7394","article-title":"Effect of particulate matter air pollution on cardiovascular oxidative stress pathways","volume":"28","author":"Rao","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"B249","doi-asserted-by":"publisher","first-page":"6601","DOI":"10.1073\/pnas.1302961110","article-title":"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways","volume":"110","author":"Rardin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B250","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s40572-022-00371-7","article-title":"Environmental chemical exposures and mitochondrial dysfunction: a review of recent literature","volume":"9","author":"Reddam","year":"2022","journal-title":"Curr. Environ. Health Rep."},{"key":"B251","doi-asserted-by":"publisher","first-page":"21528","DOI":"10.1073\/pnas.1215849110","article-title":"Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila","volume":"109","author":"Rera","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1183\/1393003.congress-2017.PA381","article-title":"Diesel exhaust exposure and sirtuins gene expression in old mice","volume":"50","author":"Ribeiro","year":"2017","journal-title":"Eur. Respir. J."},{"key":"B253","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ecoenv.2018.11.139","article-title":"Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice","volume":"170","author":"Ribeiro J\u00fanior","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B254","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13148-019-0713-2","article-title":"Air pollution and DNA methylation: effects of exposure in humans","volume":"11","author":"Rider","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"B255","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.envres.2018.09.002","article-title":"Extracellular vesicle-enriched microRNAs interact in the association between long-term particulate matter and blood pressure in elderly men","volume":"167","author":"Rodosthenous","year":"2018","journal-title":"Environ. Res."},{"key":"B256","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/s0531-5565(03)00209-2","article-title":"Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly","volume":"38","author":"Rose","year":"2003","journal-title":"Exp. Gerontol."},{"key":"B257","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1534\/genetics.118.301613","article-title":"Estimates of the heritability of human longevity are substantially inflated due to assortative mating","volume":"210","author":"Ruby","year":"2018","journal-title":"Genetics"},{"key":"B258","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nrm2298","article-title":"Multivalent engagement of chromatin modifications by linked binding modules","volume":"8","author":"Ruthenburg","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B259","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1093\/ndt\/14.9.2087","article-title":"Rapamycin on trial","volume":"14","author":"Sacks","year":"1999","journal-title":"Nephrol. Dial. Transpl."},{"key":"B260","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"B261","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","article-title":"Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB","volume":"22","author":"Sarbassov","year":"2006","journal-title":"Mol. Cell"},{"key":"B262","doi-asserted-by":"publisher","first-page":"6829","DOI":"10.18632\/aging.204248","article-title":"New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary","volume":"14","author":"Schmauck-Medina","year":"2022","journal-title":"Aging"},{"key":"B263","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.chest.2018.10.041","article-title":"Air pollution and noncommunicable diseases: a review by the forum of international respiratory societies\u2019 environmental committee, Part 2: air pollution and organ systems","volume":"155","author":"Schraufnagel","year":"2019","journal-title":"Chest"},{"key":"B264","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/toxsci\/kfab147","article-title":"Neuroinflammatory and neurometabolomic consequences from inhaled wildfire smoke-derived particulate matter in the western United States","volume":"186","author":"Scieszka","year":"2022","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"B265","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1002\/mds.27387","article-title":"Targeting aged astrocytes may Be a new therapeutic strategy in Parkinson\u2019s disease","volume":"33","author":"Scott","year":"2018","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"key":"B266","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.cell.2012.10.047","article-title":"The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism","volume":"151","author":"Sebasti\u00e1n","year":"2012","journal-title":"Cell"},{"key":"B267","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1126\/science.1177221","article-title":"Ribosomal protein S6 kinase 1 signaling regulates mammalian life span","volume":"326","author":"Selman","year":"2009","journal-title":"Science"},{"key":"B268","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142422","article-title":"Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression","volume":"75","author":"Shilatifard","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"B269","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.celrep.2013.10.007","article-title":"SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease","volume":"5","author":"Shin","year":"2013","journal-title":"Cell Rep."},{"key":"B270","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1534\/g3.117.300141","article-title":"Intricate and cell type-specific populations of endogenous circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens","volume":"7","author":"Shoura","year":"2017","journal-title":"G3 Bethesda Md"},{"key":"B271","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.3390\/biomedicines9111574","article-title":"Sirtuin 3 (SIRT3) pathways in age-related cardiovascular and neurodegenerative diseases","volume":"9","author":"Silaghi","year":"2021","journal-title":"Biomedicines"},{"key":"B272","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1007\/s12035-016-9951-x","article-title":"Mitochondrial metabolism power SIRT2-dependent deficient traffic causing alzheimer\u2019s-disease related pathology","volume":"54","author":"Silva","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"B273","doi-asserted-by":"publisher","first-page":"113466","DOI":"10.1016\/j.expneurol.2020.113466","article-title":"Unique signatures of stress-induced senescent human astrocytes","volume":"334","author":"Simmnacher","year":"2020","journal-title":"Exp. Neurol."},{"key":"B274","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/s0092-8674(00)80493-6","article-title":"Extrachromosomal rDNA circles-a cause of aging in yeast","volume":"91","author":"Sinclair","year":"1997","journal-title":"Cell"},{"key":"B275","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tma.2020.08.003","article-title":"SPOCK, an R based package for high-throughput analysis of growth rate, survival, and chronological lifespan in yeast","volume":"4","author":"Small","year":"2020","journal-title":"Transl. Med. Aging"},{"key":"B276","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.3390\/ijms22063107","article-title":"Understanding the potential role of sirtuin 2 on aging: consequences of SIRT2.3 overexpression in senescence","volume":"22","author":"Sola-Sevilla","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B277","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.neuro.2016.11.001","article-title":"Exposure to ambient ultrafine particulate matter alters the expression of genes in primary human neurons","volume":"58","author":"Solaimani","year":"2017","journal-title":"Neurotoxicology"},{"key":"B362","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.jaci.2015.10.021","article-title":"Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution","volume":"137","author":"Somineni","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"B278","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jes.2020.12.007","article-title":"Application of a real-ambient fine particulate matter exposure system on different animal models","volume":"105","author":"Song","year":"2021","journal-title":"J. Environ. Sci. China"},{"key":"B279","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-biochem-060815-014616","article-title":"Mechanisms and functions of spatial protein quality control","volume":"86","author":"Sontag","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"B280","doi-asserted-by":"publisher","first-page":"2583601","DOI":"10.1155\/2020\/2583601","article-title":"The emerging role of senescence in ocular disease","volume":"2020","author":"Sreekumar","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B281","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3390\/cancers12030558","article-title":"Telomeres and telomere length: A general overview","volume":"12","author":"Srinivas","year":"2020","journal-title":"Cancers"},{"key":"B282","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.3390\/jcm9082596","article-title":"Mechanisms of mitochondrial dysfunction in lysosomal storage disorders: A review","volume":"9","author":"Stepien","year":"2020","journal-title":"J. Clin. Med."},{"key":"B283","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1128\/MMBR.64.2.435-459.2000","article-title":"Acetylation of histones and transcription-related factors","volume":"64","author":"Sterner","year":"2000","journal-title":"Microbiol. Mol. Biol. Rev. MMBR"},{"key":"B284","doi-asserted-by":"crossref","DOI":"10.20944\/preprints202101.0004.v1","volume-title":"Mixture effects of heavy metals on insulin resistance in shipyard welders","author":"Su","year":"2021"},{"key":"B285","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1128\/MCB.00586-15","article-title":"SIRT3 blocks aging-associated tissue fibrosis in mice by deacetylating and activating glycogen synthase kinase 3\u03b2","volume":"36","author":"Sundaresan","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"B286","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.14336\/AD.2019.1130","article-title":"Age-related decline in expression of molecular chaperones induces endoplasmic reticulum stress and chondrocyte apoptosis in articular cartilage","volume":"11","author":"Tan","year":"2020","journal-title":"Aging Dis."},{"key":"B287","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/cm.20253","article-title":"SIRT2, tubulin deacetylation, and oligodendroglia differentiation","volume":"65","author":"Tang","year":"2008","journal-title":"Cell Motil. Cytoskelet."},{"key":"B288","doi-asserted-by":"publisher","first-page":"e010797","DOI":"10.1161\/JAHA.118.010797","article-title":"Preconception exposure to fine particulate matter leads to cardiac dysfunction in adult male offspring","volume":"7","author":"Tanwar","year":"2018","journal-title":"J. Am. Heart Assoc. Cardiovasc. Cerebrovasc. Dis."},{"key":"B364","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1136\/oemed-2012-101079","article-title":"Blood hypomethylation of inflammatory genes mediates the effects of metal-rich airborne pollutants on blood coagulation","volume":"70","author":"Tarantini","year":"2013","journal-title":"Occup. Environ. Med."},{"key":"B289","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nsmb.3202","article-title":"SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence","volume":"23","author":"Tasselli","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B290","doi-asserted-by":"publisher","first-page":"a004440","DOI":"10.1101\/cshperspect.a004440","article-title":"Aging as an event of proteostasis collapse","volume":"3","author":"Taylor","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B291","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.celrep.2019.03.104","article-title":"Notch signaling mediates secondary senescence","volume":"27","author":"Teo","year":"2019","journal-title":"Cell Rep."},{"key":"B292","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1699-0463.1998.tb01346.x","article-title":"Lipofuscin: mechanisms of formation and increase with age","volume":"106","author":"Terman","year":"1998","journal-title":"APMIS Acta Pathol. Microbiol. Immunol. Scand."},{"key":"B293","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3967\/bes2020.023","article-title":"Comparative ligandomic analysis of human lung epithelial cells exposed to PM 2.5","volume":"33","author":"Tian","year":"2020","journal-title":"Biomed. Environ. Sci. Bes."},{"key":"B367","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.envres.2017.10.036","article-title":"Acute particulate matter affects cardiovascular autonomic modulation and IFN-gamma methylation in healthy volunteers","volume":"161","author":"Tobaldini","year":"2018","journal-title":"Environ. Res."},{"key":"B294","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2006.04.003","article-title":"Histone lysine demethylases and their impact on epigenetics","volume":"125","author":"Trojer","year":"2006","journal-title":"Cell"},{"key":"B295","doi-asserted-by":"publisher","first-page":"105860","DOI":"10.1016\/j.envint.2020.105860","article-title":"Prenatal particulate air pollution exposure and expression of the miR-17\/92 cluster in cord blood: findings from the ENVIRONAGE birth cohort","volume":"142","author":"Tsamou","year":"2020","journal-title":"Environ. Int."},{"key":"B296","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nature21356","article-title":"Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity","volume":"543","author":"Turner","year":"2017","journal-title":"Nature"},{"key":"B297","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/toxsci\/kfy014","article-title":"Aging exacerbates neuroinflammatory outcomes induced by acute ozone exposure","volume":"163","author":"Tyler","year":"2018","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"B298","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12989-016-0177-x","article-title":"Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes","volume":"13","author":"Tyler","year":"2016","journal-title":"Part. Fibre Toxicol."},{"key":"B299","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s11357-010-9172-6","article-title":"Lipid metabolism in long-lived families: the leiden longevity study","volume":"33","author":"Vaarhorst","year":"2011","journal-title":"Age Dordr. Neth."},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.630186","article-title":"Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives","volume":"11","author":"Vaiserman","year":"2021","journal-title":"Front. Genet."},{"key":"B301","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1161\/CIRCRESAHA.107.164558","article-title":"Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice","volume":"102","author":"Vakhrusheva","year":"2008","journal-title":"Circ. Res."},{"key":"B302","doi-asserted-by":"publisher","first-page":"e08778","DOI":"10.1016\/j.heliyon.2022.e08778","article-title":"Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980\u20132020","volume":"8","author":"Valderrama","year":"2022","journal-title":"Heliyon"},{"key":"B303","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.arr.2017.06.005","article-title":"Historical demography and longevity genetics: back to the future","volume":"38","author":"van den Berg","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"B304","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41467-018-07925-0","article-title":"Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait","volume":"10","author":"van den Berg","year":"2019","journal-title":"Nat. Commun."},{"key":"B305","first-page":"147","article-title":"Insulin, IGF-1 and longevity","volume":"1","author":"van Heemst","year":"2010","journal-title":"Aging Dis."},{"key":"B306","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.15252\/embj.201593499","article-title":"SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair","volume":"35","author":"Vazquez","year":"2016","journal-title":"EMBO J."},{"key":"B307","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/j.1474-9726.2007.00329.x","article-title":"Aging and regulated protein degradation: who has the UPPer hand?","volume":"6","author":"Vernace","year":"2007","journal-title":"Aging Cell"},{"key":"B308","doi-asserted-by":"publisher","first-page":"721","DOI":"10.7164\/antibiotics.28.721","article-title":"Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle","volume":"28","author":"V\u00e9zina","year":"1975","journal-title":"J. Antibiot. (Tokyo)"},{"key":"B309","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fendo.2011.00032","article-title":"The intricate role of growth hormone in metabolism","volume":"2","author":"Vijayakumar","year":"2011","journal-title":"Front. Endocrinol."},{"key":"B310","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.tma.2017.09.003","article-title":"Genome instability and aging: cause or effect?","volume":"1","author":"Vijg","year":"2017","journal-title":"Transl. Med. Aging"},{"key":"B311","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1146\/annurev-physiol-030212-183715","article-title":"Genome instability and aging","volume":"75","author":"Vijg","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"B312","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nm.3569","article-title":"Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice","volume":"20","author":"Villeda","year":"2014","journal-title":"Nat. Med."},{"key":"B313","doi-asserted-by":"publisher","first-page":"106191","DOI":"10.1016\/j.envint.2020.106191","article-title":"Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts","volume":"146","author":"Vinggaard","year":"2021","journal-title":"Environ. Int."},{"key":"B314","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1089\/ars.2020.8048","article-title":"Senescence in post-mitotic cells: A driver of aging?","volume":"34","author":"von Zglinicki","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"B315","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1007\/s10815-021-02331-w","article-title":"Inhibition of LINE-1 retrotransposition represses telomere reprogramming during mouse 2-cell embryo development","volume":"38","author":"Wang","year":"","journal-title":"J. Assist. Reprod. Genet."},{"key":"B316","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s12967-021-02927-x","article-title":"Extrachromosomal circular DNA: a new potential role in cancer progression","volume":"19","author":"Wang","year":"","journal-title":"J. Transl. Med."},{"key":"B317","doi-asserted-by":"publisher","first-page":"74510","DOI":"10.18632\/oncotarget.12903","article-title":"Long-term exposure to air pollution is associated with biological aging","volume":"7","author":"Ward-Caviness","year":"2016","journal-title":"Oncotarget"},{"key":"B318","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10577-018-9594-z","article-title":"Keeping ribosomal DNA intact: a repeating challenge","volume":"27","author":"Warmerdam","year":"2019","journal-title":"Chromosome Res."},{"key":"B319","first-page":"191","article-title":"Protection of the hematopoietic system by parabiosis","volume":"9","author":"Warren","year":"1960","journal-title":"Lab. Investig. J. Tech. Methods Pathol."},{"key":"B320","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s1096-6374(02)00018-7","article-title":"The role of growth hormone in fetal development","volume":"12","author":"Waters","year":"2002","journal-title":"Growth Horm. IGF Res. Off. J. Growth Horm. Res. Soc. Int. IGF Res. Soc."},{"key":"B321","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/newbio239197a0","article-title":"Origin of concatemeric T7DNA","volume":"239","author":"Watson","year":"1972","journal-title":"Nat. New Biol."},{"key":"B322","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/toxsci\/kfp186","article-title":"Urban particulate matter causes ER stress and the unfolded protein response in human lung cells","volume":"112","author":"Watterson","year":"2009","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2022.4686","article-title":"Exposure to particulate matter alters neutrophil lysosomal function and activation status","volume":"60","author":"Watts","year":"2022","journal-title":"Eur. Respir. J."},{"key":"B324","doi-asserted-by":"publisher","first-page":"107002","DOI":"10.1289\/EHP5131","article-title":"Air pollution, clustering of particulate matter components, and breast cancer in the sister study: A U.S.-Wide cohort","volume":"127","author":"White","year":"","journal-title":"Environ. Health Perspect."},{"key":"B325","doi-asserted-by":"publisher","first-page":"105071","DOI":"10.1016\/j.envint.2019.105071","article-title":"Air pollution, particulate matter composition and methylation-based biologic age","volume":"132","author":"White","year":"","journal-title":"Environ. Int."},{"key":"B326","volume-title":"Wildfires","year":"2017"},{"key":"B327","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1474-9726.2010.00650.x","article-title":"Familial longevity is marked by enhanced insulin sensitivity","volume":"10","author":"Wijsman","year":"2011","journal-title":"Aging Cell"},{"key":"B328","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s10552-011-9788-6","article-title":"Association of secondhand smoke exposures with DNA methylation in bladder carcinomas","volume":"22","author":"Wilhelm-Benartzi","year":"2011","journal-title":"Cancer Causes Control CCC"},{"key":"B329","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2174\/1567205015666181109103742","article-title":"Alterations in the expression of amyloid precursor protein cleaving enzymes mRNA in alzheimer peripheral blood","volume":"16","author":"Wongchitrat","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"B330","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-019-1763-5","article-title":"Circular ecDNA promotes accessible chromatin and high oncogene expression","volume":"575","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"B331","doi-asserted-by":"publisher","first-page":"4428","DOI":"10.1021\/acschemneuro.1c00468","article-title":"SIRT5 represses neurotrophic pathways and a\u03b2 production in Alzheimer\u2019s disease by targeting autophagy","volume":"12","author":"Wu","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"B332","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1089\/thy.2010.1646","article-title":"Genetic alterations in the phosphatidylinositol-3 kinase\/Akt pathway in thyroid cancer","volume":"20","author":"Xing","year":"2010","journal-title":"Thyroid. Off. J. Am. Thyroid. Assoc."},{"key":"B333","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1093\/gerona\/glw154","article-title":"Transplanted senescent cells induce an osteoarthritis-like condition in mice","volume":"72","author":"Xu","year":"2017","journal-title":"J. Gerontol. A. Biol. Sci. Med. Sci."},{"key":"B334","doi-asserted-by":"publisher","first-page":"8796","DOI":"10.1093\/nar\/gkab660","article-title":"A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase","volume":"49","author":"Xu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"B335","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1161\/STROKEAHA.115.010835","article-title":"Vascular cell senescence contributes to blood-brain barrier breakdown","volume":"47","author":"Yamazaki","year":"2016","journal-title":"Stroke"},{"key":"B336","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s11427-016-0060-7","article-title":"Sirtuin 5: a review of structure, known inhibitors and clues for developing new inhibitors","volume":"60","author":"Yang","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"B337","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2016.10.016","article-title":"Mitochondrial sirtuin network reveals dynamic SIRT3-dependent deacetylation in response to membrane depolarization","volume":"167","author":"Yang","year":"2016","journal-title":"Cell"},{"key":"B338","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12940-021-00718-x","article-title":"Interaction of sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China","volume":"20","author":"Yao","year":"2021","journal-title":"Environ. Health"},{"key":"B354","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1073\/pnas.0705896105","article-title":"Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban\/industrial location","volume":"105","author":"Yauk","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B339","doi-asserted-by":"publisher","first-page":"11959","DOI":"10.18632\/oncotarget.3851","article-title":"Systemic attenuation of the TGF-\u03b2 pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal","volume":"6","author":"Yousef","year":"2015","journal-title":"Oncotarget"},{"key":"B340","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/s41591-019-0440-4","article-title":"Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1","volume":"25","author":"Yousef","year":"2019","journal-title":"Nat. Med."},{"key":"B341","doi-asserted-by":"publisher","first-page":"100108","DOI":"10.1016\/j.xinn.2021.100108","article-title":"Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity","volume":"2","author":"Yu","year":"2021","journal-title":"Innov. Camb. Mass"},{"key":"B342","doi-asserted-by":"publisher","first-page":"256","DOI":"10.2174\/1874609808999150831112939","article-title":"Age-related decrease of sirtuin 2 protein in human peripheral blood mononuclear cells","volume":"8","author":"Yudoh","year":"2015","journal-title":"Curr. Aging Sci."},{"key":"B343","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bbrc.2018.05.113","article-title":"Amelioration of myocardial ischemia-reperfusion injury by SIRT4 involves mitochondrial protection and reduced apoptosis","volume":"502","author":"Zeng","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B344","doi-asserted-by":"publisher","first-page":"3629","DOI":"10.1093\/nar\/gkv1504","article-title":"Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents","volume":"44","author":"Zhang","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B345","doi-asserted-by":"publisher","first-page":"e25158","DOI":"10.7554\/eLife.25158","article-title":"SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation","volume":"6","author":"Zhang","year":"2017","journal-title":"eLife"},{"key":"B346","doi-asserted-by":"publisher","first-page":"140979","DOI":"10.1016\/j.scitotenv.2020.140979","article-title":"Exposure to microplastics cause gut damage, locomotor dysfunction, epigenetic silencing, and aggravate cadmium (Cd) toxicity in Drosophila","volume":"744","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"B347","doi-asserted-by":"publisher","first-page":"48092","DOI":"10.21037\/cdt.2018.06.05","article-title":"Air pollution and telomere length: a systematic review of 12,058 subjects","volume":"8","author":"Zhao","year":"","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"B348","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted protein degradation: mechanisms, strategies and application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"B349","doi-asserted-by":"publisher","first-page":"e34701","DOI":"10.7554\/eLife.34701","article-title":"A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models","volume":"7","author":"Zhao","year":"","journal-title":"eLife"},{"key":"B350","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cell.2009.12.041","article-title":"The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha","volume":"140","author":"Zhong","year":"2010","journal-title":"Cell"},{"key":"B351","doi-asserted-by":"publisher","first-page":"19055","DOI":"10.1038\/s41598-020-76118-x","article-title":"Inhibition of red blood cell development by arsenic-induced disruption of GATA-1","volume":"10","author":"Zhou","year":"2020","journal-title":"Sci. Rep."},{"key":"B352","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1159\/000067426","article-title":"The role of mitogen-activated protein kinase pathways in Alzheimer\u2019s disease","volume":"11","author":"Zhu","year":"2002","journal-title":"Neurosignals"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.792555","article-title":"Extrachromosomal circular DNA (eccDNA): from chaos to function","volume":"9","author":"Zuo","year":"2022","journal-title":"Front. Cell Dev. Biol."}],"container-title":["Frontiers in Toxicology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/ftox.2023.1267667\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T09:51:16Z","timestamp":1697017876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/ftox.2023.1267667\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":372,"alternative-id":["10.3389\/ftox.2023.1267667"],"URL":"https:\/\/doi.org\/10.3389\/ftox.2023.1267667","relation":{},"ISSN":["2673-3080"],"issn-type":[{"value":"2673-3080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"article-number":"1267667"}}