{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:57:10Z","timestamp":1771930630011,"version":"3.50.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the clinical characteristics and misdiagnosis causes of arsenic-induced peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case of arsenic-induced peripheral neuropathy initially misdiagnosed as Guillain-Barr\u00e9 syndrome, with analysis of clinical characteristics, diagnostic workup and therapeutic management, supplemented by literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 58-year-old male presented with progressive peripheral neuropathy, initially diagnosed with Guillain-Barr\u00e9 syndrome but later suspected as chronic inflammatory demyelinating polyneuropathy. However, his symptoms progressed despite standard immunotherapy, developing generalized motor deficits, myokymia, ascending sensory loss, and facial palsy. Careful reevaluation revealed critical diagnostic clues: a history of intermittent topical application of an unidentified herbal medicine preceding symptom onset, accompanying gastrointestinal prodromal symptoms, and characteristic physical findings including Mee\u2019s lines, lower limb hyperpigmentation, and foot hyperkeratosis. Subsequent laboratory testing confirmed markedly elevated arsenic levels in nail and hair samples, ultimately establishing the diagnosis of arsenic-induced peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Arsenic-induced peripheral neuropathy can clinically mimic Guillain-Barr\u00e9 syndrome. For immunotherapy-refractory cases, clinicians should maintain high suspicion for potential heavy metal poisoning. Careful elicitation of toxic exposure history and recognition of characteristic dermatologic findings are critical for definitive diagnosis, as early recognition significantly improves prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/ftox.2026.1722489","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T22:10:21Z","timestamp":1770243021000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of arsenic-induced peripheral neuropathy misdiagnosed as Guillain-Barr\u00e9 syndrome"],"prefix":"10.3389","volume":"8","author":[{"given":"Shanshan","family":"Fu","sequence":"first","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanao","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Zhan","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xia","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyan","family":"Pan","sequence":"additional","affiliation":[{"name":"The Second Clinical College, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zequan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyou","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"928","DOI":"10.33588\/rn.3810.2004011","article-title":"Acute polyneuropathy and encephalopathy caused by arsenic poisoning","volume":"38","author":"Berbel-Garcia","year":"2004","journal-title":"Rev. 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