{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T23:01:43Z","timestamp":1780009303784,"version":"3.53.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:p>Hyperbaric oxygen therapy (HBOT) is effective in managing ischemic encephalopathy of various etiologies, particularly following acute intoxication with specific gases. Considering the limited clinical evidence regarding HBOT for hypoxic encephalopathy induced by occupational exposure to toxic gases, investigating this therapeutic approach is clinically important. We report two cases of occupational poisoning due to inhalation of high-concentration toxic gases, both presenting with loss of consciousness and significant neurological deficits. Case 1 involved biogas inhalation, and case 2 involved hydrogen sulfide exposure. Following HBOT, both patients demonstrated significant neurological recovery compared to their pre-treatment status. These findings indicate that HBOT reduces neurological impairment and is associated with favorable clinical outcomes. Therefore, HBOT should be considered for ischemic encephalopathy secondary to high-risk occupational gas exposure. This approach holds potential clinical significance for preventing severe neurological sequelae in workers at risk and provides clinicians with evidence-based guidance for managing toxic gas-induced neurological injury.<\/jats:p>","DOI":"10.3389\/ftox.2026.1782213","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T22:10:33Z","timestamp":1780006233000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperbaric oxygen therapy for ischemic encephalopathy following occupational exposure to high-concentration toxic gases: two Case Reports"],"prefix":"10.3389","volume":"8","author":[{"given":"Yang","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Hejin City People\u2019s Hospital","place":["Yuncheng, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Ninth Hospital of Xi\u2019an","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hejin Traditional Chinese Medicine Hospital","place":["Yuncheng, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Hejin City People\u2019s Hospital","place":["Yuncheng, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hejin City People\u2019s Hospital","place":["Yuncheng, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/cc7151","article-title":"Bench-to-bedside review: oxygen as a drug","volume":"13","author":"Bitterman","year":"2009","journal-title":"Crit. 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