{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:13:11Z","timestamp":1788232391351,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"\n Background<\/jats:title>\n \n Gelsemium elegans<\/jats:italic>\n Benth, commonly known as \u201cduan chang cao\u201d, is a highly toxic plant belonging to the family\n Gelsemiaceae<\/jats:italic>\n . It is distributed in southern China with its potent toxicity poses a persistent threat to public health.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This study aims to comprehensively characterize the epidemiology and clinical features of\n Gelsemium<\/jats:italic>\n poisoning in Guangxi, Southern China, based on surveillance data, in order to provide an evidence-based foundation for timely and effective prevention and control measures.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A secondary analysis was conducted on 10 years of\n Gelsemium<\/jats:italic>\n poisoning surveillance data (2015\u20132024) from Guangxi. Descriptive statistics were applied to summarize epidemiological patterns and clinical manifestations.\n <\/jats:p>\n <\/jats:sec>\n \n Result<\/jats:title>\n \n From 2015 to 2024,\n Gelsemium<\/jats:italic>\n poisoning in Guangxi showed a high but fluctuating mortality rate, peaking at 100% in 2015. The highest mortality risk (19.0%) occurred in individuals aged 20\u201359 years. Cases clustered geographically in Chongzuo, Yulin, Guigang, Qinzhou, and Laibin, with incidence peaking in autumn. Alcohol infusion was the leading cause of fatal poisoning (29.5%), mainly in household and rural banquet settings. Consumption of the rhizome resulted in the highest death rate (21.1%). Dizziness and blurred vision were common clinical symptoms. Significant differences in incidence, hospitalization, and mortality rates were observed based on location, season, cooking method, source part, and misidentification (\n P<\/jats:italic>\n &lt; 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Enhancing surveillance, food safety regulations, and targeted health education plays a key role in preventing\n Gelsemium<\/jats:italic>\n poisoning. Establishing strong monitoring and quick intervention systems may further reduce its impact.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/ftox.2026.1821880","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:10:30Z","timestamp":1782943830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological and clinical analysis of Gelsemium poisoning in Guangxi, Southern China: a decade of surveillance data"],"prefix":"10.3389","volume":"8","author":[{"given":"Yanxu","family":"Zhong","sequence":"first","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Centre for Disease Control and Prevention","place":["Nanning, China"]},{"name":"Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis, Guangxi Zhuang Autonomous Region Centre for Disease Control and Prevention","place":["Nanning, China"]},{"name":"Guangxi Zhuang Autonomous Region Academy of Preventive Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Centre for Disease Control and Prevention","place":["Nanning, China"]},{"name":"Guangxi Zhuang Autonomous Region Academy of Preventive Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Centre for Disease Control and Prevention","place":["Nanning, China"]},{"name":"Guangxi Zhuang Autonomous Region Academy of Preventive Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitian","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Public Health, Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Public Health, Youjiang Medical University for Nationalities","place":["Baise, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangxi Zhuang Autonomous Region Centre for Disease Control and Prevention","place":["Nanning, China"]},{"name":"Guangxi Zhuang Autonomous Region Academy of Preventive Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.toxicon.2020.04.093","article-title":"Comparative toxicokinetic profiles of multiple-components of Gelsemium elegans in pigs and rats after a single oral administration","volume":"181","author":"Cao","year":"2020","journal-title":"Toxicon"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3969\/j.issn.1673-8535.2020.03.003","article-title":"Literature analysis of 1034 cases of gelsemium poisoning incidents","author":"Chen","year":"2020","journal-title":"J. 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