{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:44:18Z","timestamp":1782960258242,"version":"3.54.5"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:p>\n                    Cisplatin-induced acute kidney injury remains a major dose-limiting complication in oncology. Human proximal tubule\n                    <jats:italic>in vitro<\/jats:italic>\n                    models are widely used to investigate nephrotoxic mechanisms; however, biomarker selection and reporting patterns vary considerably across studies. This PRISMA-guided systematic review aimed to characterize the frequency, biological categorization, and co-reporting patterns of biomarkers used in human proximal tubule\n                    <jats:italic>in vitro<\/jats:italic>\n                    models of cisplatin-induced injury. A systematic search of PubMed, Scopus, and Web of Science identified experimental\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies published between 2014 and 2024 that reported quantifiable biomarkers following cisplatin exposure. Biomarkers were classified into predefined structural injury, regulated cell death, and mechanistic categories. Descriptive frequency analyses were performed, and co-occurrence relationships among the 12 most frequently reported biomarkers were evaluated using a binary presence\u2013absence matrix. Fifty-eight studies met inclusion criteria. Kidney injury molecule-1 was the most frequently reported structural biomarker. Mechanistic endpoints, particularly oxidative stress and intracellular signaling markers, predominated over structural injury markers. Co-reporting analysis revealed recurrent pathway-oriented groupings, suggesting hypothesis-driven panel selection rather than standardized implementation across studies. These findings highlight the need for improved harmonization and structured biomarker strategies to enhance reproducibility, predictive robustness, and translational alignment in vitro nephrotoxicity research.\n                  <\/jats:p>","DOI":"10.3389\/ftox.2026.1862941","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:59:11Z","timestamp":1782957551000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomarker selection and reporting architecture in human proximal tubular in vitro models of cisplatin-induced nephrotoxicity: a systematic review"],"prefix":"10.3389","volume":"8","author":[{"given":"Mar\u00eda Gabriella","family":"Rodr\u00edguez-Marcano","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universidad de Las Am\u00e9ricas","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Pierucci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Las Am\u00e9ricas","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Romero Lugo","sequence":"additional","affiliation":[{"name":"Health Sciences Faculty, School of Medicine, Universidad Internacional SEK (UISEK)","place":["Quito, Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1681\/ASN.2015010060","article-title":"A quantitative approach to screen for nephrotoxic compounds in vitro","volume":"27","author":"Adler","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.tiv.2014.10.005","article-title":"Application of RPTEC\/TERT1 cells for investigation of repeat dose nephrotoxicity: a transcriptomic study","volume":"30","author":"Aschauer","year":"2015","journal-title":"Toxicol. Vitro"},{"key":"B3","doi-asserted-by":"publisher","first-page":"69797","DOI":"10.1038\/s41598-024-69797-3","article-title":"Renogrit selectively protects against cisplatin-induced injury in HK-2 and C. elegans by harmonizing apoptosis and mitophagy","volume":"14","author":"Balkrishna","year":"2024","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5436","DOI":"10.26355\/eurrev_202109_26651","article-title":"The therapeutic effect of cilastatin on drug-induced nephrotoxicity: a new perspective","volume":"25","author":"Becerir","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1093\/ndt\/gfp010","article-title":"Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more","volume":"24","author":"Bonventre","year":"2009","journal-title":"Nephrol. Dial. Transpl."},{"key":"B6","doi-asserted-by":"publisher","first-page":"155407","DOI":"10.1016\/j.phymed.2024.155407","article-title":"Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction","volume":"126","author":"Cai","year":"2024","journal-title":"Phytomedicine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3389\/fphar.2020.00241","article-title":"SIRT1 mediates effects of FGF21 to ameliorate cisplatin-induced acute kidney injury","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1515\/cclm-2011-0814","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury","volume":"50","author":"Clerico","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"829630","DOI":"10.3389\/fphar.2022.829630","article-title":"Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1126348","DOI":"10.3389\/fimmu.2023.1126348","article-title":"Identification and validation of hub genes in drug-induced acute kidney injury based on integrated transcriptomic analysis","volume":"14","author":"Deng","year":"2023","journal-title":"Front. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"F971","DOI":"10.1152\/ajprenal.00597.2019","article-title":"Evaluation of cisplatin-induced injury in human kidney organoids","volume":"318","author":"Digby","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1007\/s00204-019-02519-0","article-title":"Kidney-based in vitro models for drug-induced toxicity testing","volume":"93","author":"Faria","year":"2019","journal-title":"Arch. Toxicol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"115003","DOI":"10.1016\/j.fct.2024.115003","article-title":"CDKN1A promotes cisplatin-induced acute kidney injury by inducing cytoplasmic ROS production and ferroptosis","volume":"193","author":"Gao","year":"2024","journal-title":"Food Chem. Toxicol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.1021\/acsbiomaterials.0c01468","article-title":"3-D human renal tubular organoids generated from urine-derived stem cells for nephrotoxicity screening","volume":"6","author":"Guo","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1230","DOI":"10.1002\/cl2.1230","article-title":"PRISMA2020: an R package and shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and open synthesis","volume":"18","author":"Haddaway","year":"2022","journal-title":"Campbell Syst. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41592-019-0325-y","article-title":"Flow-enhanced vascularization and maturation of kidney organoids in vitro","volume":"16","author":"Homan","year":"2019","journal-title":"Nat. Methods"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1038\/s41419-020-2256-z","article-title":"VDR activation attenuates cisplatin-induced acute kidney injury by inhibiting ferroptosis","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1039\/C3IB40049B","article-title":"Human kidney proximal tubule-on-a-chip","volume":"5","author":"Jang","year":"2013","journal-title":"Integr. Biol. (Camb)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1158\/2767-9764.CRC-22-0340","article-title":"Targeting NEDDylation is a novel strategy to attenuate cisplatin-induced nephrotoxicity","volume":"3","author":"Jones","year":"2023","journal-title":"Cancer Res. Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1093\/toxsci\/kfu096","article-title":"Identification of noninvasive biomarkers for nephrotoxicity using HK-2 human kidney epithelial cells","volume":"140","author":"Kim","year":"2014","journal-title":"Toxicol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1021\/mp400637s","article-title":"Identification of nephrotoxic compounds with embryonic stem-cell-derived human renal proximal tubular-like cells","volume":"11","author":"Li","year":"2014","journal-title":"Mol. Pharm."},{"key":"B22","doi-asserted-by":"publisher","first-page":"115563","DOI":"10.1016\/j.biopha.2023.115563","article-title":"Carnosine alleviates cisplatin-induced acute kidney injury by targeting caspase-1-regulated pyroptosis","volume":"166","author":"Luo","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B23","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/psp4.12400","article-title":"Translational assessment of drug-induced proximal tubule injury using a kidney microphysiological system","volume":"8","author":"Maass","year":"2019","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3140680","DOI":"10.1155\/2017\/3140680","article-title":"Ameliorative effect of daidzein on cisplatin-induced nephrotoxicity in mice via modulation of inflammation, oxidative stress, and cell death","volume":"2017","author":"Meng","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins (Basel)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.xphs.2023.11.018","article-title":"Identification of novel and early biomarkers for cisplatin-induced nephrotoxicity and the nephroprotective role of cimetidine using a pharmacometabolomic-based approach coupled with in vitro toxicodynamic modeling and simulation","volume":"113","author":"Mody","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"9794570","DOI":"10.1155\/2016\/9794570","article-title":"Evaluation of \u201cDream Herb,\u201d calea zacatechichi, for nephrotoxicity using human kidney proximal tubule cells","volume":"2016","author":"Mossoba","year":"2016","journal-title":"J. Toxicol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"key":"B29","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1039\/c8tx00095f","article-title":"An in vitro method for nephrotoxicity evaluation using HK-2 human kidney epithelial cells combined with biomarkers of nephrotoxicity","volume":"7","author":"Qiu","year":"2018","journal-title":"Toxicol. Res. (Camb)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/toxres\/tfaa005","article-title":"Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity in RPTEC\/TERT1 cells","volume":"9","author":"Qiu","year":"2020","journal-title":"Toxicol. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"8225","DOI":"10.1038\/s41598-017-08474-0","article-title":"Inhibin-A and decorin secreted by human adult renal stem\/progenitor cells through the TLR2 engagement induce renal tubular cell regeneration","volume":"7","author":"Sallustio","year":"2017","journal-title":"Sci. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00204-006-0173-2","article-title":"Cisplatin-induced nephrotoxicity is associated with oxidative stress and mitochondrial dysfunction","volume":"81","author":"Santos","year":"2007","journal-title":"Arch. Toxicol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41419-021-03458-5","article-title":"Caspase 3\/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity","volume":"12","author":"Shen","year":"2021","journal-title":"Cell Death Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s12011-015-0339-y","article-title":"The RPTEC\/TERT1 cell line as an improved tool for in vitro nephrotoxicity assessments","volume":"166","author":"Simon-Friedt","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.3390\/jof8101002","article-title":"Nephroprotective effects of two ganoderma species methanolic extracts in an in vitro model of cisplatin-induced tubulotoxicity","volume":"8","author":"Sinaeve","year":"2022","journal-title":"J. Fungi (Basel)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2223957","DOI":"10.1155\/2022\/2223957","article-title":"Mitochondrial targeted antioxidant SKQ1 ameliorates acute kidney injury by inhibiting ferroptosis","volume":"2022","author":"Song","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1080\/0886022X.2018.1456938","article-title":"Cisplatin-induced oxidative stress stimulates renal fas ligand shedding","volume":"40","author":"Soni","year":"2018","journal-title":"Ren. Fail."},{"key":"B39","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/jcmm.13926","article-title":"\u03b3-Secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling","volume":"23","author":"Soni","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.biomaterials.2018.07.059","article-title":"Guided tissue organization and disease modeling in a kidney tubule array","volume":"183","author":"Subramanian","year":"2018","journal-title":"Biomaterials"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1138504","DOI":"10.3389\/fcell.2023.1138504","article-title":"ATP\/ADP biosensor organoids for drug nephrotoxicity assessment","volume":"11","author":"Susa","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1027517","DOI":"10.3389\/fbioe.2022.1027517","article-title":"The construction of oligonucleotide-cycloastragenol and the renoprotective effect study","volume":"10","author":"Tang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10495-015-1190-5","article-title":"Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity","volume":"21","author":"Trist\u00e3o","year":"2016","journal-title":"Apoptosis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1208\/s12248-018-0248-z","article-title":"Nephrotoxicity and kidney transport assessment on 3D perfused proximal tubules","volume":"20","author":"Vormann","year":"2018","journal-title":"AAPS J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/s41401-021-00649-w","article-title":"Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis","volume":"43","author":"Wang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"B46","doi-asserted-by":"publisher","first-page":"100730","DOI":"10.1016\/j.bj.2024.100730","article-title":"Olesoxime protects against cisplatin-induced acute kidney injury by attenuating mitochondrial dysfunction","volume":"48","author":"Wang","year":"2025","journal-title":"Biomed. J."},{"key":"B47","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13020-022-00574-y","article-title":"Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3\/TGF-\u03b21 and Smad3\/p38 MAPK pathways","volume":"17","author":"Wei","year":"2022","journal-title":"Chin. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"5580","DOI":"10.1021\/acs.nanolett.1c01840","article-title":"Nephrotoxicity assessment with human kidney tubuloids using spherical nucleic acid-based mRNA nanoflares","volume":"21","author":"Wiraja","year":"2021","journal-title":"Nano Lett."},{"key":"B49","doi-asserted-by":"publisher","first-page":"153202","DOI":"10.1016\/j.phymed.2020.153202","article-title":"7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation","volume":"69","author":"Wu","year":"2020","journal-title":"Phytomedicine"},{"key":"B50","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/s41419-022-05220-x","article-title":"Regulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through JNK\/Mff signaling pathway","volume":"13","author":"Xiao","year":"2022","journal-title":"Cell Death Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"F322","DOI":"10.1152\/ajprenal.00229.2021","article-title":"Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury","volume":"323","author":"Xie","year":"2022","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"153653","DOI":"10.1016\/j.tox.2023.153653","article-title":"Role of myo-inositol in acute kidney injury induced by cisplatin","volume":"491","author":"Xie","year":"2023","journal-title":"Toxicology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.7150\/ijbs.58910","article-title":"Long non-coding RNA MEG3 promotes cisplatin-induced nephrotoxicity through regulating AKT\/TSC\/mTOR-mediated autophagy","volume":"17","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"116595","DOI":"10.1016\/j.taap.2023.116595","article-title":"Dihydromyricetin attenuates cisplatin-induced acute kidney injury","volume":"469","author":"Xu","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1080\/10715762.2017.1361532","article-title":"Renoprotective mechanisms of astragaloside IV in cisplatin-induced acute kidney injury","volume":"51","author":"Yan","year":"2017","journal-title":"Free Radic. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1042\/CS20171625","article-title":"Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury","volume":"132","author":"Yang","year":"2018","journal-title":"Clin. Sci. (Lond)"},{"key":"B57","doi-asserted-by":"publisher","first-page":"106999","DOI":"10.1016\/j.intimp.2020.106999","article-title":"LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis","volume":"88","author":"Yang","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.freeradbiomed.2020.01.182","article-title":"Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2","volume":"152","author":"Yang","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3401067","DOI":"10.1155\/2020\/3401067","article-title":"Ginsenoside Rh1 alleviates HK-2 apoptosis by inhibiting ROS and the JNK\/p53 pathways","volume":"2020","author":"Yang","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"153541","DOI":"10.1016\/j.phymed.2021.153541","article-title":"Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7\/IGF1R-mediated programmed cell death and inflammation","volume":"85","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"B61","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.bbrc.2021.06.097","article-title":"Dok3 is involved in cisplatin-induced acute kidney injury via regulation of inflammation and apoptosis","volume":"569","author":"Yang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/MAJ.0b013e31812dfe1e","article-title":"Cisplatin nephrotoxicity: a review","volume":"334","author":"Yao","year":"2007","journal-title":"Am. J. Med. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"105794","DOI":"10.1016\/j.bioorg.2022.105794","article-title":"Discovery of a novel GRPR antagonist for protection against cisplatin-induced acute kidney injury","volume":"124","author":"Yu","year":"2022","journal-title":"Bioorg. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.3390\/molecules24213876","article-title":"Eleutheroside B protects against acute kidney injury by activating IGF pathway","volume":"24","author":"Zang","year":"2019","journal-title":"Molecules"},{"key":"B65","doi-asserted-by":"publisher","first-page":"11718","DOI":"10.1111\/jcmm.15782","article-title":"Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis via SIRT1\/p53 signalling","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1049\/iet-nbt.2019.0247","article-title":"Functional role of microRNA-500a-3P-loaded liposomes in the treatment of cisplatin-induced AKI","volume":"14","author":"Zhang","year":"2020","journal-title":"IET Nanobiotechnol"}],"container-title":["Frontiers in Toxicology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/ftox.2026.1862941\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:59:12Z","timestamp":1782957552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/ftox.2026.1862941\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":66,"alternative-id":["10.3389\/ftox.2026.1862941"],"URL":"https:\/\/doi.org\/10.3389\/ftox.2026.1862941","relation":{},"ISSN":["2673-3080"],"issn-type":[{"value":"2673-3080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"article-number":"1862941"}}