{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:25:39Z","timestamp":1787178339300,"version":"build-2736575974"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute oral benzene poisoning is uncommon, and evidence to guide extracorporeal treatment and bedside toxicokinetic interpretation in this setting is limited. Most published experience concerns inhalational exposure or chronic hematotoxicity, leaving clinicians with little practical guidance for managing large intentional ingestions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>An 18-year-old man presented approximately 12\u00a0h after ingesting about 200\u00a0mL of a commercial benzene standard solution in ethyl acetate as intentional self-poisoning. On admission he had tachycardia, persistent gastrointestinal symptoms, and laboratory confirmation of exposure, with benzene detected in gastric fluid (2,966\u00a0\u03bcg\/L), blood (457\u00a0\u03bcg\/L), and urine (224\u00a0\u03bcg\/L). Before gastric lavage, toxicological confirmation was obtained in all three matrices. After decontamination and supportive care, sequential hemoperfusion and continuous veno-venous hemodiafiltration (CVVHDF) were initiated. Serial toxicological monitoring showed rapid decline of the parent compound\u2014blood benzene decreased to 228\u00a0\u03bcg\/L at 20\u00a0h, 78\u00a0\u03bcg\/L at 28\u00a0h, and became undetectable by 32\u00a0h\u2014whereas urinary phenol rose later, peaking at 3231.5\u00a0mg\/L at 32\u00a0h before declining over subsequent days. The clinical course included rhabdomyolysis, transient liver injury, erosive gastritis, and transient nonspecific white-matter abnormalities on brain magnetic resonance imaging (MRI). The patient recovered without persistent neurologic deficit and returned to usual activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In severe acute oral ingestion of a benzene-containing solvent, paired monitoring of the parent compound and a major metabolite provided clinically useful information to contextualize extracorporeal treatment when formal decision thresholds were unavailable. This case cannot establish treatment efficacy, but it illustrates a pragmatic monitoring framework that may assist clinicians interpreting late toxicokinetic trends in rare but high-risk solvent ingestions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/ftox.2026.1875489","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:10:15Z","timestamp":1787177415000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Serial blood benzene and urinary phenol monitoring during extracorporeal treatment after severe acute oral ingestion of a benzene-containing solvent"],"prefix":"10.3389","volume":"8","author":[{"given":"Junting","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Maternal and Child Health Hospital of Hubei Province","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Maternal and Child Health Hospital of Hubei Province","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Physics and Chemistry Laboratory, Hubei Provincial Hospital of Integrated Chinese and Western Medicine","place":["Wuhan, China"]},{"name":"Hubei Provincial Clinical Research Center for Pneumoconiosis and Poisoning","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","volume-title":"Toxicological Profile for Benzene","year":"2024"},{"key":"B2","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.kint.2018.03.026","article-title":"Use of extracorporeal treatments in the management of poisonings","volume":"94","author":"Ghannoum","year":"2018","journal-title":"Kidney Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1136\/oem.43.10.692","article-title":"Quantitative relation of urinary phenol levels to breathzone benzene concentrations: a factory survey","volume":"43","author":"Inoue","year":"1986","journal-title":"Br. 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