{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:00:53Z","timestamp":1786114853292,"version":"build-2736575974"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Toxicol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\u03b2-mercaptoethanol is widely used in biochemistry and industrial applications. Animal toxicity has been demonstrated but very limited data exists regarding its human effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>A 40-year-old male patient was exposed to \u03b2-mercaptoethanol vapours after an accidental occupational spillage. He developed dizziness, blurred vision, a headache and epistaxis within minutes alongside dyspnoea and cough in the following hours. Lung function tests displayed bronchial hyperreactivity and increased resistances, consistent with a reactive airways dysfunction syndrome. Neuropsychological testing showed memory difficulties affecting both working and long-term verbal memory, together with attentional and executive weaknesses. Twenty months after the incident, the patient still experienced memory impairment and dyspnoea while bronchial hyperreactivity remained present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Respiratory exposure to large quantities of \u03b2-mercaptoethanol vapours can cause reactive airways dysfunction syndrome and is associated with long-term neurological and respiratory symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/ftox.2026.1916362","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:10:16Z","timestamp":1785967816000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: acute and long-term effects of a massive beta-mercaptoethanol inhalation"],"prefix":"10.3389","volume":"8","author":[{"given":"Marion","family":"Bernard","sequence":"first","affiliation":[{"name":"Department of Pneumology, CHU UCL Namur","place":["Yvoir, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Van Brussel","sequence":"additional","affiliation":[{"name":"Service de Pr\u00e9vention et Protection Au Travail-CESI","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Lardinois","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU UCL Namur","place":["Yvoir, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Doyen","sequence":"additional","affiliation":[{"name":"Department of Pneumology, CHU UCL Namur","place":["Yvoir, Belgium"]},{"name":"Pole of Lung, Nose and Skin (LUNS), Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois M.","family":"Carlier","sequence":"additional","affiliation":[{"name":"Department of Pneumology, CHU UCL Namur","place":["Yvoir, Belgium"]},{"name":"Pole of Lung, Nose and Skin (LUNS), Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Plant\u00e9-Bordeneuve","sequence":"additional","affiliation":[{"name":"Department of Pneumology, CHU UCL Namur","place":["Yvoir, Belgium"]},{"name":"Pole of Lung, Nose and Skin (LUNS), Institut de Recherche Exp\u00e9rimentale et Clinique (IREC), Universit\u00e9 Catholique de Louvain","place":["Brussels, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1378\/chest.88.3.376","article-title":"Reactive airways dysfunction syndrome (RADS): persistent asthma syndrome after high level irritant exposures","volume":"88","author":"Brooks","year":"1985","journal-title":"Chest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1601526","DOI":"10.1183\/13993003.01526-2016","article-title":"ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests","volume":"49","author":"Coates","year":"2017","journal-title":"Eur. 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