{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:38:11Z","timestamp":1787060291588,"version":"build-2736575974"},"reference-count":28,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2015.00064","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T01:01:36Z","timestamp":1448499696000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolic Encephalopathy and Lipid Storage Myopathy Associated with a Presumptive Mitochondrial Fatty Acid Oxidation Defect in a Dog"],"prefix":"10.3389","volume":"2","author":[{"given":"Vanessa R.","family":"Biegen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"McCue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn A.","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Diane","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/vr.101671","article-title":"Cerebrospinal fluid lactate and pyruvate concentrations and ratio in healthy adult dogs","volume":"173","author":"Gal\u00e1n-Rodriguez","year":"2013","journal-title":"Vet Rec"},{"key":"B2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fneur.2013.00172","article-title":"Prospects of levetiracetam as a neuroprotective drug against status epilepticus, traumatic brain injury, and stroke","volume":"4","author":"Shetty","year":"2013","journal-title":"Front Neurol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/978-1-60761-459-3_41","article-title":"Urine organic acid analysis for inherited metabolic disease using gas chromatography-mass spectrometry","volume":"603","author":"Jones","year":"2010","journal-title":"Methods Mol Biol"},{"key":"B4","first-page":"708","article-title":"Metabolic, nutritional, iatrogenic, and artifactual sources of urinary organic acids: a comprehensive table","volume":"48","author":"Kumps","year":"2002","journal-title":"Clin Chem"},{"key":"B5","volume-title":"Inborn Metabolic Diseases","year":"2006","edition":"4th ed"},{"key":"B6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/978-1-61737-985-7_3","article-title":"Acylcarnitines: analysis in plasma and whole blood using tandem mass spectrometry","volume":"708","author":"Millington","year":"2011","journal-title":"Methods Mol Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/GIM.0b013e3181614289","article-title":"Acylcarnitine profile analysis","volume":"10","author":"Rinaldo","year":"2008","journal-title":"Genet Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1136\/jmg.2006.042507","article-title":"L-2-hydroxyglutaric aciduria: characterization of the molecular defect in a spontaneous canine model","volume":"44","author":"Penderis","year":"2007","journal-title":"J Med Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1023\/A:1005635306257","article-title":"Malonic aciduria in Maltese dogs: normal methymalonic acid concentrations and malonyl-CoA decarboxylase activity in fibroblasts","volume":"22","author":"O\u2019Brien","year":"1999","journal-title":"J Inherit Metab Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF02237961","article-title":"Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy","volume":"11","author":"Podell","year":"1996","journal-title":"Metab Brain Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0960-8966(01)00308-X","article-title":"Defects of mitochondrial \u00df-oxidation: a growing group of disorders","volume":"12","author":"Vockley","year":"2002","journal-title":"Neuromuscul Disord"},{"key":"B12","doi-asserted-by":"publisher","first-page":"163","DOI":"10.5326\/0430163","article-title":"Refractory seizures associated with an organic aciduria in a dog","volume":"43","author":"Platt","year":"2007","journal-title":"J Am Anim Hosp Assoc"},{"key":"B13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.nmd.2008.02.007","article-title":"Acquired multiple acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy","volume":"18","author":"Westermann","year":"2008","journal-title":"Neuromuscul Disord"},{"key":"B14","volume-title":"Textbook of Medical Physiology","year":"2006","edition":"11th ed"},{"key":"B15","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.spen.2008.05.008","article-title":"Mitochondrial fatty-acid oxidation disorders","volume":"15","author":"Kompare","year":"2008","journal-title":"Semin Pediatr Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.ymgme.2005.09.009","article-title":"Brain abnormalities in a case of malonyl-CoA decarboxylase deficiency","volume":"87","author":"de Wit","year":"2006","journal-title":"Mol Genet Metab"},{"key":"B17","doi-asserted-by":"publisher","first-page":"24461","DOI":"10.1074\/jbc.274.35.24461","article-title":"MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency","volume":"274","author":"Sacksteder","year":"1999","journal-title":"J Biol Chem"},{"key":"B18","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1086\/302492","article-title":"The molecular basis of malonyl-CoA decarboxylase deficiency","volume":"65","author":"FitzPatrick","year":"1999","journal-title":"Am J Hum Genet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10545-013-9611-5","article-title":"Pathophysiology of fatty acid oxidation disorders and resultant phenotypic variability","volume":"36","author":"Olpin","year":"2013","journal-title":"J Inherit Metab Dis"},{"key":"B20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.biochi.2013.05.012","article-title":"Regulation of mitochondrial fatty acid \u00df-oxidation in human: what can we learn from inborn fatty acid \u00df-oxidation deficiencies?","volume":"96","author":"Bastin","year":"2014","journal-title":"Biochimie"},{"key":"B21","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/0387-7604(94)90102-3","article-title":"Movement disorders in childhood organic acidurias: clinical, neuroimaging and biochemical correlations","volume":"16","author":"Gascon","year":"1994","journal-title":"Brain Dev"},{"key":"B22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/0387-7604(94)90103-1","article-title":"CT and MR of the brain in the diagnosis of organic acidemias: experiences from 107 patients","volume":"16","author":"Brismar","year":"1994","journal-title":"Brain Dev"},{"issue":"2","key":"B23","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/dmcn.12045","article-title":"Topography of brain damage in metabolic hypoglycaemia is determined by age at which hypoglycaemia occurred","volume":"55","author":"Gataullina","year":"2013","journal-title":"Dev Med Child Neurol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1748-5827.1999.tb03028.x","article-title":"Subacute necrotising encephalopathy in an Alaskan husky","volume":"40","author":"Wakshlag","year":"1999","journal-title":"J Small Anim Pract"},{"key":"B25","first-page":"275","article-title":"Magnetic resonance imaging of GM2-gangliosidosis in a golden retriever","volume":"46","author":"Matsuki","year":"2005","journal-title":"Can Vet J"},{"issue":"5","key":"B26","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1292\/jvms.71.689","article-title":"Insulinoma with basal ganglion involvement detected by magnetic resonance imaging in a dog","volume":"71","author":"Fukazawa","year":"2009","journal-title":"J Vet Med Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.nmd.2010.06.018","article-title":"Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges","volume":"20","author":"Lafor\u00eat","year":"2010","journal-title":"Neuromuscul Disord"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1002\/(SICI)1097-4598(199809)21:91202::AID-MUS133.0.CO;2-T","article-title":"Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy","volume":"21","author":"Shelton","year":"1998","journal-title":"Muscle Nerve"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"deposited":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T16:04:33Z","timestamp":1448985873000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fvets.2015.00064\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":28,"URL":"https:\/\/doi.org\/10.3389\/fvets.2015.00064","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}