{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:23:01Z","timestamp":1773112981966,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2016.00066","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T23:05:09Z","timestamp":1472079909000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Prophylactic Administration of Vector-Encoded Porcine Granulocyte-Colony Stimulating Factor Reduces Salmonella Shedding, Tonsil Colonization, and Microbiota Alterations of the Gastrointestinal Tract in Salmonella-Challenged Swine"],"prefix":"10.3389","volume":"3","author":[{"given":"Shawn M. D.","family":"Bearson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley L.","family":"Bearson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal L.","family":"Loving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather K.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"InSoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darin","family":"Madson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus E.","family":"Kehrli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"B1","author":"NAHMS","year":"2009","journal-title":"Salmonella on U.S. Swine Sites \u2013 Prevalence and Antimicrobial Susceptibility"},{"issue":"1530","key":"B2","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1098\/rstb.2009.0094","article-title":"Molecular insights into farm animal and zoonotic Salmonella infections","volume":"364","author":"Stevens","year":"2009","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"9","key":"B3","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1017\/S0950268812002464","article-title":"Longitudinal study of Salmonella shedding in naturally infected finishing pigs","volume":"141","author":"Pires","year":"2013","journal-title":"Epidemiol Infect"},{"issue":"1","key":"B4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.20506\/rst.17.1.1094","article-title":"Cytokines orchestrating the immune response","volume":"17","author":"Lunney","year":"1998","journal-title":"Rev Sci Tech"},{"issue":"Suppl 2","key":"B5","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1007\/BF01705024","article-title":"The role of GM-CSF in infection","volume":"20","author":"Freund","year":"1992","journal-title":"Infection"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/(SICI)1096-8652(199801)57:17::AID-AJH23.0.CO;2-0","article-title":"Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers","volume":"57","author":"Dale","year":"1998","journal-title":"Am J Hematol"},{"issue":"3","key":"B7","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"B8","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/mi.2012.24","article-title":"The role of neutrophils during intestinal inflammation","volume":"5","author":"Fournier","year":"2012","journal-title":"Mucosal Immunol"},{"issue":"2","key":"B9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00520-014-2457-z","article-title":"Efficacy, effectiveness and safety of long-acting granulocyte colony-stimulating factors for prophylaxis of chemotherapy-induced neutropenia in patients with cancer: a systematic review","volume":"23","author":"Pfeil","year":"2015","journal-title":"Support Care Cancer"},{"issue":"12","key":"B10","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.3168\/jds.S0022-0302(89)79293-6","article-title":"Effects of recombinant granulocyte colony-stimulating factor on Staphylococcus aureus mastitis in lactating dairy cows","volume":"72","author":"Nickerson","year":"1989","journal-title":"J Dairy Sci"},{"issue":"5","key":"B11","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1177\/030098589002700502","article-title":"Hemogram changes in lactating dairy cows given human recombinant granulocyte colony stimulating factor (r-MethuG-CSF)","volume":"27","author":"Cullor","year":"1990","journal-title":"Vet Pathol"},{"issue":"1","key":"B12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1939-165X.1990.tb00534.x","article-title":"Effects of human recombinant granulocyte colony stimulating factor (HR-GCSF) on the hemogram of lactating dairy cattle","volume":"19","author":"Cullor","year":"1990","journal-title":"Vet Clin Pathol"},{"issue":"12","key":"B13","doi-asserted-by":"publisher","first-page":"4399","DOI":"10.3168\/jds.S0022-0302(91)78420-8","article-title":"Immunobiology of hematopoietic colony-stimulating factors: potential application to disease prevention in the bovine","volume":"74","author":"Kehrli","year":"1991","journal-title":"J Dairy Sci"},{"issue":"6","key":"B14","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.biologicals.2013.07.001","article-title":"Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils","volume":"41","author":"Loving","year":"2013","journal-title":"Biologicals"},{"issue":"3","key":"B15","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1574-695X.2006.00051.x","article-title":"Neutrophil influx during non-typhoidal salmonellosis: who is in the driver\u2019s seat?","volume":"46","author":"Tukel","year":"2006","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"1","key":"B16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1258\/la.2007.007084","article-title":"Porcine in vitro and in vivo models to assess the virulence of Salmonella enterica serovar Typhimurium for pigs","volume":"43","author":"Boyen","year":"2009","journal-title":"Lab Anim"},{"issue":"12","key":"B17","doi-asserted-by":"publisher","first-page":"e28768","DOI":"10.1371\/journal.pone.0028768","article-title":"Distinct peripheral blood RNA responses to Salmonella in pigs differing in Salmonella shedding levels: intersection of IFNG, TLR and miRNA pathways","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"B18","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/1753425914525812","article-title":"Salmonella enterica serovar Typhimurium-infected pigs with different shedding levels exhibit distinct clinical, peripheral cytokine and transcriptomic immune response phenotypes","volume":"21","author":"Knetter","year":"2015","journal-title":"Innate Immun"},{"issue":"3\u20134","key":"B19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0165-2427(02)00165-4","article-title":"Characterisation of a resource population of pigs screened for resistance to salmonellosis","volume":"88","author":"van Diemen","year":"2002","journal-title":"Vet Immunol Immunopathol"},{"issue":"6","key":"B20","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.micpath.2010.03.005","article-title":"The Salmonella enterica serovar Typhimurium QseB response regulator negatively regulates bacterial motility and swine colonization in the absence of the QseC sensor kinase","volume":"48","author":"Bearson","year":"2010","journal-title":"Microb Pathog"},{"issue":"4","key":"B21","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1128\/AEM.72.4.2829-2836.2006","article-title":"Identification of Salmonella enterica serovar Typhimurium genes important for survival in the swine gastric environment","volume":"72","author":"Bearson","year":"2006","journal-title":"Appl Environ Microbiol"},{"issue":"17","key":"B22","doi-asserted-by":"publisher","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13104-016-2172-6","article-title":"Pipeline for amplifying and analyzing amplicons of the V1 -V3 region of the 16S rRNA gene","volume":"9","author":"Allen","year":"2016","journal-title":"BMC Res Notes"},{"issue":"23","key":"B24","doi-asserted-by":"publisher","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"B25","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/bioinformatics\/bts075","article-title":"Estimating population diversity with CatchAll","volume":"28","author":"Bunge","year":"2012","journal-title":"Bioinformatics"},{"key":"B26","first-page":"9","article-title":"PAST: paleontological statistics software package for education and data analysis","volume":"4","author":"Hammer","year":"2001","journal-title":"Palaeontol Electronica"},{"issue":"Database issue","key":"B27","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetmic.2007.12.017","article-title":"Non-typhoidal Salmonella infections in pigs: a closer look at epidemiology, pathogenesis and control","volume":"130","author":"Boyen","year":"2008","journal-title":"Vet Microbiol"},{"issue":"3\u20134","key":"B29","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.vetmic.2007.10.031","article-title":"A limited role for SsrA\/B in persistent Salmonella Typhimurium infections in pigs","volume":"128","author":"Boyen","year":"2008","journal-title":"Vet Microbiol"},{"issue":"1\u20132","key":"B30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.vetmic.2009.12.021","article-title":"Salmonella Typhimurium resides largely as an extracellular pathogen in porcine tonsils, independently of biofilm-associated genes csgA, csgD and adrA","volume":"144","author":"Van Parys","year":"2010","journal-title":"Vet Microbiol"},{"issue":"1\u20132","key":"B31","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.vetmic.2011.10.004","article-title":"Salmonella enterica serovar Typhimurium and Enteritidis infection of pigs and cytokine signalling in palatine tonsils","volume":"156","author":"Volf","year":"2012","journal-title":"Vet Microbiol"},{"issue":"1","key":"B32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/08977190500055836","article-title":"G-CSF: a key regulator of neutrophil production, but that\u2019s not all!","volume":"23","author":"Roberts","year":"2005","journal-title":"Growth Factors"},{"issue":"3","key":"B33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/risa.12586","article-title":"A quantitative microbiological risk assessment for Salmonella in pigs for the European Union","volume":"36","author":"Snary","year":"2016","journal-title":"Risk Anal"},{"issue":"2","key":"B34","first-page":"65","article-title":"Social stress increases fecal shedding of Salmonella Typhimurium by early weaned piglets","volume":"7","author":"Callaway","year":"2006","journal-title":"Curr Issues Intest Microbiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1297-9716-42-118","article-title":"Stress induced Salmonella Typhimurium recrudescence in pigs coincides with cortisol induced increased intracellular proliferation in macrophages","volume":"42","author":"Verbrugghe","year":"2011","journal-title":"Vet Res"},{"issue":"7314","key":"B36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nature09415","article-title":"Gut inflammation provides a respiratory electron acceptor for Salmonella","volume":"467","author":"Winter","year":"2010","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.meegid.2013.03.022","article-title":"Profiling the gastrointestinal microbiota in response to Salmonella: low versus high Salmonella shedding in the natural porcine host","volume":"16","author":"Bearson","year":"2013","journal-title":"Infect Genet Evol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-micro-091014-104108","article-title":"The pyromaniac inside you: Salmonella metabolism in the host gut","volume":"69","author":"Rivera-Chavez","year":"2015","journal-title":"Annu Rev Microbiol"},{"key":"B39","author":"FDA","year":"2012","journal-title":"The Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals: Guidance for Industry #209"},{"key":"B40","author":"FDA","year":"2013","journal-title":"New Animal Drugs and New Animal Drug Combination Products Administered in or on Medicated Feed or Drinking Water of Food-Producing Animals: Recommendations for Drug Sponsors for Voluntarily Aligning Product Use Conditions with GFI #209: Guidance for Industry #213"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T17:20:23Z","timestamp":1498324823000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fvets.2016.00066\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":40,"URL":"https:\/\/doi.org\/10.3389\/fvets.2016.00066","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}