{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T18:29:50Z","timestamp":1772389790936,"version":"3.50.1"},"reference-count":58,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2016.00067","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T12:00:57Z","timestamp":1472126457000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Preventive Chlamydia abortus Vaccination in Offspring Development in Sheep Challenged Experimentally"],"prefix":"10.3389","volume":"3","author":[{"given":"Teresa","family":"Garc\u00eda-Seco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"P\u00e9rez-Sancho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"D\u00edez-Guerrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Pozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Goyache","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"issue":"2","key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.syapm.2014.12.004","article-title":"Emendation of the family Chlamydiaceae: proposal of a single genus, Chlamydia, to include all currently recognized species","volume":"38","author":"Sachse","year":"2015","journal-title":"Syst Appl Microbiol"},{"issue":"6","key":"B2","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/infdis\/174.6.1296","article-title":"Localization of chronic Chlamydia psittaci infection in the reproductive tract of sheep","volume":"174","author":"Papp","year":"1996","journal-title":"J Infect Dis"},{"issue":"4","key":"B3","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0007-1935(11)80027-8","article-title":"Clinical and immunological responses of ewes following vaccination with an experimental formalin-inactivated Chlamydia psittaci (ovis) vaccine and subsequent challenge with the live organism during pregnancy","volume":"146","author":"Wilsmore","year":"1990","journal-title":"Br Vet J"},{"issue":"1\u20132","key":"B4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.vetmic.2004.01.015","article-title":"Efficacy of different commercial and new inactivated vaccines against ovine enzootic abortion","volume":"100","author":"Garc\u00eda de la Fuente","year":"2004","journal-title":"Vet Microbiol"},{"issue":"4","key":"B5","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1053\/jcpa.2002.0629","article-title":"Animal chlamydioses and zoonotic implications","volume":"128","author":"Longbottom","year":"2003","journal-title":"J Comp Pathol"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cvfa.2010.10.017","article-title":"Treatment and control of chlamydial and rickettsial infections in sheep and goats","volume":"27","author":"Stuen","year":"2011","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"2","key":"B7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.tvjl.2012.06.018","article-title":"Evaluation of the impact and control of enzootic abortion of ewes","volume":"195","author":"Longbottom","year":"2013","journal-title":"Vet J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1746-6148-3-24","article-title":"Ovine enzootic abortion (OEA): a comparison of antibody responses in vaccinated and naturally-infected Swiss sheep over a two year period","volume":"3","author":"Gerber","year":"2007","journal-title":"BMC Vet Res"},{"issue":"1\u20132","key":"B9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.vetmic.2015.07.010","article-title":"Chlamydiaceae and chlamydial infections in sheep or goats","volume":"181","author":"Rodolakis","year":"2015","journal-title":"Vet Microbiol"},{"issue":"1","key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rvsc.2004.08.004","article-title":"Immunopathology of Chlamydophila abortus infection in sheep and mice","volume":"78","author":"Kerr","year":"2005","journal-title":"Res Vet Sci"},{"issue":"Suppl 1","key":"B11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11259-005-0839-x","article-title":"Rechallenge of previously-infected pregnant ewes with Chlamydophila abortus","volume":"29","author":"Sammin","year":"2005","journal-title":"Vet Res Commun"},{"issue":"3\u20134","key":"B12","first-page":"275","article-title":"Recent advances on ovine chlamydial abortion","volume":"29","author":"Rodolakis","year":"1998","journal-title":"Vet Res"},{"issue":"6","key":"B13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/014107680109400605","article-title":"Chlamydial infection in sheep: immune control versus fetal pathology","volume":"94","author":"Entrican","year":"2001","journal-title":"J R Soc Med"},{"key":"B14","article-title":"2.7.7 Enzootic abortion of ewes (ovine chlamydiosis)","volume-title":"Manual of Diagnostic Tests and Vaccines for Terrestrial Animals","author":"OIE","year":"2015"},{"issue":"3","key":"B15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/vr.141.3.63","article-title":"Use of a live chlamydial vaccine to prevent ovine enzootic abortion","volume":"141","author":"Chalmers","year":"1997","journal-title":"Vet Rec"},{"issue":"5","key":"B16","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1080\/00480169.2015.1018365","article-title":"Identification of the 1B vaccine strain of Chlamydia abortus in aborted placentas during the investigation of toxaemic and systemic disease in sheep","volume":"63","author":"Sargison","year":"2015","journal-title":"N Z Vet J"},{"issue":"35","key":"B17","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1016\/j.vaccine.2010.04.114","article-title":"Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion","volume":"28","author":"Wheelhouse","year":"2010","journal-title":"Vaccine"},{"issue":"1","key":"B18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0378-1135(90)90047-Y","article-title":"Efficacy against ovine enzootic abortion of an experimental vaccine containing purified elementary bodies of Chlamydia psittaci","volume":"24","author":"Anderson","year":"1990","journal-title":"Vet Microbiol"},{"issue":"5","key":"B19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2460\/javma.1990.196.05.731","article-title":"Efficacy of a vaccine to prevent Chlamydia- or Campylobacter-induced abortions in ewes","volume":"196","author":"Hansen","year":"1990","journal-title":"J Am Vet Med Assoc"},{"issue":"5","key":"B20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0378-1135(82)90066-9","article-title":"Efficacy of a bacterin prepared from Chlamydia psittaci grown in cell culture for experimental immunization of ewes","volume":"7","author":"Waldhalm","year":"1982","journal-title":"Vet Microbiol"},{"issue":"3","key":"B21","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.tvjl.2015.04.036","article-title":"Intratracheal infection as an efficient route for testing vaccines against Chlamydia abortus in sheep","volume":"205","author":"\u00c1lvarez","year":"2015","journal-title":"Vet J"},{"issue":"6","key":"B22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/vr.126.6.136","article-title":"Enzootic abortion of ewes","volume":"126","author":"Aitken","year":"1990","journal-title":"Vet Rec"},{"issue":"8","key":"B23","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/0264-410X(94)00068-X","article-title":"Efficacy trials with tissue-culture grown, inactivated vaccines against chlamydial abortion in sheep","volume":"13","author":"Jones","year":"1995","journal-title":"Vaccine"},{"issue":"17","key":"B24","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1136\/vr.105.17.387","article-title":"Field studies on enzootic abortion of ewes in south east Scotland","volume":"105","author":"Linklater","year":"1979","journal-title":"Vet Rec"},{"key":"B25","first-page":"735","article-title":"Brucellosis vaccine (live), freeze-dried, for veterinary use","volume-title":"European Pharmacopoeia","author":"Council of Europe (COE), European Directorate for the Quality of Medicines (Edqm)","year":"2010","edition":"5th ed"},{"issue":"5","key":"B26","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1128\/IAI.67.5.2110-2116.1999","article-title":"Role of polymorphonuclear neutrophils in a murine model of Chlamydia psittaci-induced abortion","volume":"67","author":"Buend\u00eda","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"B27","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.tvjl.2008.02.025","article-title":"New real-time PCR tests for species-specific detection of Chlamydophila psittaci and Chlamydophila abortus from tissue samples","volume":"181","author":"Pantchev","year":"2009","journal-title":"Vet J"},{"key":"B28","volume-title":"MedCalc Software for Windows, Version 16.4.3","author":"MedCalc","year":"2016"},{"key":"B29","volume-title":"SPSS Statistics for Windows, Version 22.0","author":"IBM","year":"2013"},{"key":"B30","volume-title":"R: A Language and Environment for Statistical Computing","author":"Core Team R","year":"2015"},{"issue":"4","key":"B31","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1214\/ss\/1177011136","article-title":"Inference from iterative simulation using multiple sequences","volume":"7","author":"Gelman","year":"1992","journal-title":"Stat Sci"},{"issue":"4","key":"B32","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1080\/10618600.1998.10474787","article-title":"General methods for monitoring convergence of iterative simulations","volume":"7","author":"Gelman","year":"1998","journal-title":"J Comput Graph Stat"},{"issue":"4","key":"B33","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/1467-9868.00353","article-title":"Bayesian measures of model complexity and fit","volume":"64","author":"Spiegelhalter","year":"2002","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"B34","volume-title":"Data Analysis Using Regression and Multilevel\/Hierarchical Models","author":"Gelman","year":"2007"},{"issue":"11","key":"B35","doi-asserted-by":"publisher","first-page":"4235","DOI":"10.1128\/JCM.40.11.4235-4243.2002","article-title":"Serological diagnosis of ovine enzootic abortion by enzyme-linked immunosorbent assay with a recombinant protein fragment of the polymorphic outer membrane protein POMP90 of Chlamydophila abortus","volume":"40","author":"Longbottom","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"2","key":"B36","first-page":"40","article-title":"Breeding performance of sheep infected with Chlamydia psittaci (ovis) during their preceding pregnancy","volume":"126","author":"Wilsmore","year":"1990","journal-title":"Vet Rec"},{"issue":"23","key":"B37","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.1016\/S0264-410X(03)00255-X","article-title":"Relationship between the immune response and protection conferred by new designed inactivated vaccines against ovine enzootic abortion in a mouse model","volume":"21","author":"Caro","year":"2003","journal-title":"Vaccine"},{"issue":"16","key":"B38","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1136\/vr.149.16.492","article-title":"Protection conferred by commercially available vaccines against Chlamydophila abortus in a mouse model","volume":"149","author":"Caro","year":"2001","journal-title":"Vet Rec"},{"issue":"1","key":"B39","first-page":"41","article-title":"Clinical evaluation of a commercial vaccine against chlamydial abortion of ewes","volume":"10","author":"Rodolakis","year":"1979","journal-title":"Ann Rech Vet"},{"issue":"3\u20134","key":"B40","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0378-1135(93)90091-K","article-title":"Comparison of serological tests for the diagnosis of Chlamydia psittaci infection of sheep","volume":"36","author":"Markey","year":"1993","journal-title":"Vet Microbiol"},{"issue":"1","key":"B41","doi-asserted-by":"publisher","first-page":"12,29","DOI":"10.1136\/vr.123.1.12","article-title":"Anti-chlamydial immunity in ewes conferred by vaccination with a combination of three live Chlamydia, Brucella and Salmonella vaccines","volume":"123","author":"Souriau","year":"1988","journal-title":"Vet Rec"},{"issue":"9","key":"B42","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1128\/IAI.58.9.3101-3108.1990","article-title":"Protection of sheep against Chlamydia psittaci infection with a subcellular vaccine containing the major outer membrane protein","volume":"58","author":"Tan","year":"1990","journal-title":"Infect Immun"},{"issue":"Suppl 1","key":"B43","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11259-005-0844-0","article-title":"Ovine enzootic abortion (OEA): antibody response in vaccinated sheep compared to naturally infected sheep","volume":"29","author":"Borel","year":"2005","journal-title":"Vet Res Commun"},{"issue":"6","key":"B44","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1128\/CDLI.12.6.770-777.2005","article-title":"Antibody responses to recombinant protein fragments of the major outer membrane protein and polymorphic outer membrane protein POMP90 in Chlamydophila abortus-infected pregnant sheep","volume":"12","author":"Livingstone","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"issue":"1\u20132","key":"B45","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.vetmic.2008.09.040","article-title":"Recent developments in the laboratory diagnosis of chlamydial infections","volume":"135","author":"Sachse","year":"2009","journal-title":"Vet Microbiol"},{"issue":"5","key":"B46","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1354\/vp.41-5-498","article-title":"Kinetics of infection and effects on the placenta of Chlamydophila abortus in experimentally infected pregnant ewes","volume":"41","author":"Navarro","year":"2004","journal-title":"Vet Pathol"},{"issue":"9","key":"B47","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1128\/IAI.62.9.3786-3792.1994","article-title":"Abortion and subsequent excretion of chlamydiae from the reproductive tract of sheep during estrus","volume":"62","author":"Papp","year":"1994","journal-title":"Infect Immun"},{"issue":"3","key":"B48","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S1090-0233(97)80060-3","article-title":"Chlamydial disease-more than just abortion","volume":"153","author":"Jones","year":"1997","journal-title":"Vet J"},{"issue":"2","key":"B49","doi-asserted-by":"publisher","first-page":"e57950","DOI":"10.1371\/journal.pone.0057950","article-title":"Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep","volume":"8","author":"Longbottom","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"B50","first-page":"155","article-title":"Response of ewes to temperature-sensitive mutants of Chlamydia psittaci (var ovis) obtained by NTG mutagenesis","volume":"14","author":"Rodolakis","year":"1983","journal-title":"Ann Rech Vet"},{"issue":"12","key":"B51","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.2460\/ajvr.1986.47.12.2627","article-title":"Response of goats to vaccination with temperature-sensitive mutants of Chlamydia psittaci obtained by nitrosoguanidine mutagenesis","volume":"47","author":"Rodolakis","year":"1986","journal-title":"Am J Vet Res"},{"issue":"4","key":"B52","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0007-1935(11)80028-X","article-title":"Protection of ewes vaccinated with A22 strain Chlamydia psittaci (ovis) against challenge in pregnancy with homologous and heterologous strains of the organism","volume":"146","author":"Wilsmore","year":"1990","journal-title":"Br Vet J"},{"issue":"2\u20133","key":"B53","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jcpa.2006.04.005","article-title":"Comparison of fetal and maternal inflammatory responses in the ovine placenta after experimental infection with Chlamydophila abortus","volume":"135","author":"Sammin","year":"2006","journal-title":"J Comp Pathol"},{"issue":"1\u20132","key":"B54","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.vetmic.2008.09.030","article-title":"Protective adaptive immunity to Chlamydophila abortus infection and control of ovine enzootic abortion (OEA)","volume":"135","author":"Rocchi","year":"2009","journal-title":"Vet Microbiol"},{"issue":"2\u20133","key":"B55","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/jcpa.2002.0573","article-title":"Ovine chlamydial abortion: characterization of the inflammatory immune response in placental tissues","volume":"127","author":"Buxton","year":"2002","journal-title":"J Comp Pathol"},{"issue":"1\u20132","key":"B56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.vetmic.2010.06.015","article-title":"Monitoring clinical outcomes, pathological changes and shedding of Chlamydophila abortus following experimental challenge of periparturient ewes utilizing the natural route of infection","volume":"147","author":"Guti\u00e9rrez","year":"2011","journal-title":"Vet Microbiol"},{"key":"B57","volume-title":"Vacunas inactivadas frente al aborto enzo\u00f3tico de los peque\u00f1os rumiantes: An\u00e1lisis de la protecci\u00f3n inducida por vacunas comerciales y de nuevo dise\u00f1o en un modelo ovino","author":"Garc\u00eda de la Fuente","year":"2013"},{"issue":"2","key":"B58","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0021-9975(08)80127-2","article-title":"Observations on the pathogenesis of Chlamydia psittaci infection of pregnant sheep","volume":"102","author":"Buxton","year":"1990","journal-title":"J Comp Pathol"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:58:49Z","timestamp":1749563929000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fvets.2016.00067\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":58,"URL":"https:\/\/doi.org\/10.3389\/fvets.2016.00067","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}