{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:53:05Z","timestamp":1791600785479,"version":"4.3.4"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001655","name":"Grayson-Jockey Club Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2018.00208","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:26:52Z","timestamp":1535675212000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint?"],"prefix":"10.3389","volume":"5","author":[{"given":"Aimee C.","family":"Colbath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Dow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leone S.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer N.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Wayne","family":"McIlwraith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie R.","family":"Goodrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1006\/bbrc.1997.7246","article-title":"IL-1 beta induces the degradation of equine articular cartilage by a mechanism that is not mediated by nitric oxide","volume":"238","author":"Bird","year":"1997","journal-title":"Biochem Biophys Res Commun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/PHM.0b013e3181157718","article-title":"Effects of intra-articular botulinum toxin type A in an equine model of acute synovitis: a pilot study","volume":"86","author":"Depuy","year":"2007","journal-title":"Am J Phys Med Rehabil."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.joca.2012.08.008","article-title":"Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide","volume":"20","author":"Ross","year":"2012","journal-title":"Osteoarthr Cartil."},{"key":"B4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2460\/ajvr.75.1.19","article-title":"Effect of anesthetizing individual compartments of the stifle joint in horses with experimentally induced stifle joint lameness","volume":"75","author":"Toth","year":"2014","journal-title":"Am J Vet Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/evj.12521","article-title":"Characterisation of lubricin in synovial fluid from horses with osteoarthritis","volume":"49","author":"Svala","year":"2015","journal-title":"Equine Vet J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3109\/03008207.2015.1027340","article-title":"An inflammatory equine model demonstrates dynamic changes of immune response and cartilage matrix molecule degradation in vitro","volume":"56","author":"Svala","year":"2015","journal-title":"Connect Tissue Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tvjl.2017.10.021","article-title":"Assessment of a novel equine tarsocrural experimental joint disease model using recombinant interleukin-1beta and arthroscopic articular sampling of the medial malleolus of the tibia on the standing sedated horse","volume":"229","author":"Nelson","year":"2017","journal-title":"Vet J."},{"key":"B8","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J Rheumatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s12253-008-9016-1","article-title":"Alterations of the CD4(+), CD8 (+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations","volume":"14","author":"Hussein","year":"2008","journal-title":"Pathol Oncol Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/sj.gt.3301608","article-title":"Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene","volume":"9","author":"Frisbie","year":"2002","journal-title":"Gene Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40634-016-0054-4","article-title":"Intra-articular interleukin-1 receptor antagonist (IL1-ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect","volume":"3","author":"Elsaid","year":"2016","journal-title":"J Exp Orthop."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e000279","DOI":"10.1136\/rmdopen-2016-000279","article-title":"Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation","volume":"2","author":"Punzi","year":"2016","journal-title":"RMD Open"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.2460\/ajvr.72.12.1586","article-title":"Comparison of the response to experimentally induced short-term inflammation in the temporomandibular and metacarpophalangeal joints of horses","volume":"72","author":"Carmalt","year":"2011","journal-title":"Am J Vet Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/evj.12477","article-title":"Equine allogeneic umbilical cord blood derived mesenchymal stromal cells reduce synovial fluid nucleated cell count and induce mild self-limiting inflammation when evaluated in an lipopolysaccharide induced synovitis model","volume":"48","author":"Williams","year":"2016","journal-title":"Equine Vet J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"700","DOI":"10.2460\/ajvr.74.5.700","article-title":"Effects of serum and autologous conditioned serum on equine articular chondrocytes treated with interleukin-1beta","volume":"74","author":"Carlson","year":"2013","journal-title":"Am J Vet Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1476-9255-11-8","article-title":"Expression of pro-inflammatory mediators is inhibited by an avocado\/soybean unsaponifiables and epigallocatechin gallate combination","volume":"11","author":"Ownby","year":"2014","journal-title":"J Inflamm."},{"key":"B17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2460\/ajvr.77.1.50","article-title":"Production of serum amyloid A in equine articular chondrocytes and fibroblast-like synoviocytes treated with proinflammatory cytokines and its effects on the two cell types in culture","volume":"77","author":"Jacobsen","year":"2016","journal-title":"Am J Vet Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/jpn.12359","article-title":"Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses","volume":"100","author":"Ross-Jones","year":"2016","journal-title":"J Anim Physiol Anim Nutr."},{"key":"B19","first-page":"342","article-title":"Characteristics of normal equine tarsal synovial fluid","volume":"31","author":"Van","year":"1967","journal-title":"Can J Comp Med Vet Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/jlb.56.5.559","article-title":"Essential involvement of interleukin-8 (IL-8) in acute inflammation","volume":"56","author":"Harada","year":"1994","journal-title":"J Leukoc Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1053\/joms.2002.33239","article-title":"Interleukin-1beta stimulates interleukin-8 production and gene expression in synovial cells from human temporomandibular joint","volume":"60","author":"Tobe","year":"2002","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2018.00208\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:26:56Z","timestamp":1535675216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2018.00208\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":21,"alternative-id":["10.3389\/fvets.2018.00208"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2018.00208","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,31]]},"article-number":"208"}}