{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:54:42Z","timestamp":1787237682333,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2019.00333","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:19:28Z","timestamp":1569975568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Babesia gibsoni GPI-anchored Protein 47 (BgGPI47-WH) as a Potential Diagnostic Antigen by Enzyme-Linked Immunosorbent Assay"],"prefix":"10.3389","volume":"6","author":[{"given":"Xueyan","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangnan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangsiqi","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,2]]},"reference":[{"key":"B1","first-page":"229","article-title":"Babesia gibsoni (Patton, 1910) from a dog in Kuala Lumpur","volume":"22","author":"Groves","year":"1968","journal-title":"Med J Malaya."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/S0020-7519(00)00120-X","article-title":"There are at least three genetically distinct small piroplasms from dogs?","volume":"30","author":"Kjemtrup","year":"2000","journal-title":"Int J Parasitol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"942","DOI":"10.2460\/javma.2005.227.942","article-title":"Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000\u20132003)","volume":"227","author":"Birkenheuer","year":"2005","journal-title":"J Am Vet Med Assoc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.3389\/fmicb.2017.01577","article-title":"First molecular detection of Babesia gibsoni in dogs from Wuhan, China","volume":"8","author":"He","year":"2017","journal-title":"Front Microbiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/0169-4758(95)80059-X","article-title":"Vaccines against babesiosis using soluble parasite antigens","volume":"11","author":"T.Schetters","year":"1995","journal-title":"Parasitol Today"},{"key":"B6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ijpara.2018.12.002","article-title":"Vaccination against babesiosis using recombinant GPI-anchored proteins","volume":"49","author":"Nathaly Wieser","year":"2019","journal-title":"Int J Parasitol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ttbdis.2013.12.011","article-title":"The glycosylphosphatidylinositol-anchored protein repertoire of Babesia bovis and its significance for erythrocyte invasion","volume":"5","author":"Rodriguez","year":"2014","journal-title":"Ticks Tick Borne Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1111\/trf.13640","article-title":"A targeted immunomic approach identifies diagnostic antigens in the human pathogen Babesia microti","volume":"56","author":"Cornillot","year":"2016","journal-title":"Transfusion"},{"key":"B9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.vetpar.2008.07.025","article-title":"Efficiency of a recombinant MSA-2c-based ELISA to establish the persistence of antibodies in cattle vaccinated with Babesia bovis","volume":"157","author":"Bono","year":"2008","journal-title":"Vet Parasitol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.vetpar.2015.05.028","article-title":"Classification of Babesia canis strains in Europe based on polymorphism of the Bc28.1-gene from the Babesia canis Bc28 multigene family","volume":"211","author":"Carcy","year":"2015","journal-title":"Vet Parasitol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3357","DOI":"10.1038\/s41598-017-03445-x","article-title":"Genome-wide analysis of gene expression and protein secretion of Babesia canis during virulent infection identifies potential pathogenicity factors","volume":"7","author":"Eichenberger","year":"2017","journal-title":"Sci Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"9495","DOI":"10.1074\/jbc.M111.260745","article-title":"Structural and functional characterization of Bc28.1, major erythrocyte-binding protein from Babesia canis merozoite surface","volume":"287","author":"Yang","year":"2012","journal-title":"J Biol Chem"},{"key":"B13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.vetpar.2011.11.021","article-title":"Occurrence of Theileria and Babesia species in water buffalo (Bubalus babalis, Linnaeus, 1758) in the Hubei province, South China","volume":"186","author":"He","year":"2012","journal-title":"Vet Parasitol"},{"key":"B14","first-page":"59","article-title":"Molecular characterization and expression of a 47-kDa merozoite surface protein of Babesia gibsoni for serodiagnosis by enzyme-linked immunosorbent assay","volume":"20","author":"Aboge","year":"2010","journal-title":"J Protozool Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.ttbdis.2015.11.005","article-title":"Genetic variations of four immunodominant antigens of Babesia gibsoni isolated from dogs in southwest Japan","volume":"7","author":"Liu","year":"2016","journal-title":"Ticks Tick Borne Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1600-065X.2010.00988.x","article-title":"Cell biology and immunology of malaria","volume":"240","author":"Hafalla","year":"2011","journal-title":"Immunol Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1093\/bib\/bbs066","article-title":"A guide to in silico vaccine discovery for eukaryotic pathogens","volume":"14","author":"Goodswen","year":"2013","journal-title":"Brief Bioinformatics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.3389\/fmicb.2017.02545","article-title":"Evaluation of a major surface antigen of Babesia microti merozoites as a vaccine candidate against Babesia infection","volume":"8","author":"Man","year":"2017","journal-title":"Front Microbiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"26951","DOI":"10.1074\/jbc.M109.013706","article-title":"Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate","volume":"284","author":"Plassmeyer","year":"2009","journal-title":"J Biol Chem"},{"key":"B20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0166-6851(02)00329-8","article-title":"Babesia bovis merozoite surface protein-2c (MSA-2c) contains highly immunogenic, conserved B-cell epitopes that elicit neutralization-sensitive antibodies in cattle","volume":"127","author":"Wilkowsky","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/hum.2006.17.415","article-title":"Vaccination with replication-deficient recombinant adenoviruses encoding the main surface antigens of toxoplasma gondii induces immune response and protection against infection in mice","volume":"17","author":"Caetano","year":"2006","journal-title":"Human Gene Ther"},{"key":"B22","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.parint.2011.11.007","article-title":"Four promising antigens, BgP32, BgP45, BgP47, and BgP50, for serodiagnosis of Babesia gibsoni infection were classified as B. gibsoni merozoite surface protein family","volume":"61","author":"Goo","year":"2012","journal-title":"Parasitol Int"},{"key":"B23","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.exppara.2007.11.010","article-title":"Babesia gibsoni: serodiagnosis of infection in dogs by an enzyme-linked immunosorbent assay with recombinant BgTRAP","volume":"118","author":"Goo","year":"2008","journal-title":"Exp Parasitol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.exppara.2011.07.011","article-title":"Expression of truncated Babesia gibsoni thrombospondin-related adhesive proteins in Escherichia coli and evaluation of their diagnostic potential by enzyme-linked immunosorbent assay","volume":"129","author":"Narantsatsral","year":"2011","journal-title":"Exp Parasitol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3347\/kjp.2014.52.4.345","article-title":"New molecules in babesia gibsoni and their application for diagnosis, vaccine development, and drug discovery","volume":"52","author":"Goo","year":"2014","journal-title":"Korean J Parasitol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1128\/CDLI.10.4.596-601.2003","article-title":"High-level expression of truncated surface antigen P50 of Babesia gibsoni in insect cells by baculovirus and evaluation of its immunogenicity and antigenicity","volume":"10","author":"Fukumoto","year":"2003","journal-title":"Clin Diagn Lab Immunol"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2019.00333\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:19:30Z","timestamp":1569975570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2019.00333\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,2]]},"references-count":26,"alternative-id":["10.3389\/fvets.2019.00333"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2019.00333","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,2]]},"article-number":"333"}}