{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:30:10Z","timestamp":1791916210765,"version":"4.3.4"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2020.00042","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T23:39:22Z","timestamp":1581032362000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["Lactobacillus reuteri Promotes Intestinal Development and Regulates Mucosal Immune Function in Newborn Piglets"],"prefix":"10.3389","volume":"7","author":[{"given":"Minjuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0151481","DOI":"10.1371\/journal.pone.0151481","article-title":"The intestinal eukaryotic virome in healthy and diarrhoeic neonatal piglets","volume":"11","author":"Karlsson","year":"2016","journal-title":"PLoS ONE."},{"key":"B2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.aninu.2017.12.004","article-title":"Gastrointestinal tract(gut) health in the young pig","volume":"4","author":"Pluske","year":"2018","journal-title":"Anim Nutr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.livsci.2008.12.001","article-title":"Performance and diarrhoea in piglets following weaning at seven weeks of age: challenge with E. coli O 149 and effect of dietary factors","volume":"123","author":"Sorensen","year":"2009","journal-title":"Livestock Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13028-017-0299-7","article-title":"Post weaning diarrhea in pigs: risk factors and non-colistin-based control strategies","volume":"59","author":"Rhouma","year":"2017","journal-title":"Acta Vet Scand."},{"key":"B5","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.tim.2012.11.001","article-title":"Treatment, promotion, commotion: antibiotic alternatives in food-producing animals","volume":"21","author":"Allen","year":"2013","journal-title":"Trends Microb."},{"key":"B6","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3389\/fmicb.2014.00334","article-title":"Use of antibiotics as feed additives: a burning question","volume":"5","author":"Chattopadhyay","year":"2014","journal-title":"Front Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.aninu.2018.03.002","article-title":"Use of antibiotics in broiler production: global impacts and alternatives","volume":"4","author":"Mehdi","year":"2018","journal-title":"Anim Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/jac\/dkg483","article-title":"Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data","volume":"53","author":"Phillips","year":"2004","journal-title":"J Antimicrob Chemother."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1016\/S2542-5196(17)30141-9","article-title":"Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis","volume":"1","author":"Tang","year":"2017","journal-title":"Lancet Planetary Health."},{"key":"B10","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1177\/1756283X16644242","article-title":"The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions","volume":"9","author":"Vindigni","year":"2016","journal-title":"Therap Adv Gastroenterol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1084\/jem.20082683","article-title":"STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing","volume":"206","author":"Pickert","year":"2009","journal-title":"J Exp Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/emmm.201100159","article-title":"Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment","volume":"3","author":"Amar","year":"2011","journal-title":"Embo Mol Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fcimb.2015.00026","article-title":"Lactobacillus protects the integrity of intestinal epithelial barrier damaged by pathogenic bacteria","volume":"5","author":"Yu","year":"2015","journal-title":"Front Cell Infect Microbiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.copbio.2017.08.004","article-title":"Intestinal Lactobacillus in health and disease, a driver or just along for the ride?","volume":"49","author":"Heeney","year":"2017","journal-title":"Curr Opin Biotechnol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e1800552","DOI":"10.1002\/mnfr.201800552","article-title":"Lactobacillus acidophilus alleviated salmonella-induced goblet cells loss and colitis by notch pathway","volume":"62","author":"Wu","year":"2018","journal-title":"Mol Nutr Food Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"13758","DOI":"10.1021\/acs.jafc.9b06256","article-title":"Lactobacillus reuteri stimulates intestinal epithelial proliferation and induces differentiation into goblet cells in young chickens","volume":"67","author":"Xie","year":"2019","journal-title":"J Agric Food Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/ismej.2009.123","article-title":"Diversification of the gut symbiont Lactobacillus reuteri as a result of host-driven evolution","volume":"4","author":"Oh","year":"2010","journal-title":"ISME J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1038\/s41418-018-0070-2","article-title":"Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22","volume":"25","author":"Hou","year":"2018","journal-title":"Cell Death Different."},{"key":"B20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.livsci.2011.01.001","article-title":"The effect of Lactobacillus on the expression of porcine beta-defensin-2 in the digestive tract of piglets","volume":"138","author":"Zhang","year":"2011","journal-title":"Livestock Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1186\/1746-6148-8-89","article-title":"Effects of lactobacillus plantarum ZJ316 on pig growth and pork quality","volume":"8","author":"Suo","year":"2012","journal-title":"BMC Vet Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.5713\/ajas.17.0746","article-title":"Effect of Lactobacillus salivarius on growth performance, diarrhea incidence, fecal bacterial population and intestinal morphology of suckling pigs challenged with F4+ enterotoxigenic Escherichia coli","volume":"31","author":"Sayan","year":"2018","journal-title":"Asian Austr J Anim Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ebiom.2017.09.029","article-title":"A small molecule inhibitor of the beta-catenin-TCF4 interaction suppresses colorectal cancer growth in vitro and in vivo","volume":"25","author":"Shin","year":"2017","journal-title":"Ebiomedicine."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1101\/gad.267103","article-title":"Canonical Wnt signals are essential for homeostasis of the intestinal epithelium","volume":"17","author":"Pinto","year":"2003","journal-title":"Genes Dev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/\u03b2-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1136\/gut.2005.068601","article-title":"Paneth cells: their role in innate immunity and inflammatory disease","volume":"54","author":"Elphick","year":"2005","journal-title":"Gut."},{"key":"B27","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3389\/fimmu.2012.00310","article-title":"Intestinal antimicrobial peptides during homeostasis, infection, and disease","volume":"3","author":"Muniz","year":"2012","journal-title":"Front Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3389\/fimmu.2017.01254","article-title":"The Peyer's patch mononuclear phagocyte system at steady state and during infection","volume":"8","author":"Da","year":"2017","journal-title":"Front Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3389\/fimmu.2018.00888","article-title":"Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes","volume":"9","author":"Junttila","year":"2018","journal-title":"Front Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-\u03b3: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity."},{"key":"B31","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/embor.2012.96","article-title":"Innate immune signalling at the intestinal epithelium in homeostasis and disease","volume":"13","author":"Pott","year":"2012","journal-title":"EMBO Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.bpg.2016.02.007","article-title":"Physiology of intestinal absorption and secretion","volume":"30","author":"Kiela","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1242\/dev.135400","article-title":"Generation of intestinal surface: an absorbing tale","volume":"143","author":"Walton","year":"2016","journal-title":"Development."},{"key":"B34","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.vetmic.2017.09.021","article-title":"Effects of porcine epidemic diarrhea virus infection on nursery pig intestinal function and barrier integrity","volume":"211","author":"Curry","year":"2017","journal-title":"Vet Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.aninu.2017.10.001","article-title":"Intestinal challenge with enterotoxigenic Escherichia coli in pigs, and nutritional intervention to prevent postweaning diarrhea","volume":"3","author":"Sun","year":"2017","journal-title":"Anim Nutr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"936193","DOI":"10.1155\/2015\/936193","article-title":"The role of innate immunity receptors in the pathogenesis of inflammatory bowel disease","volume":"2015","author":"Elia","year":"2015","journal-title":"Mediat Inflamm."},{"key":"B37","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/MOG.0b013e3283506559","article-title":"Innate immunity in the small intestine","volume":"28","author":"Santaolalla","year":"2012","journal-title":"Curr Opin Gastroenterol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"20234","DOI":"10.1074\/jbc.M114.553800","article-title":"Activation of epidermal growth factor receptor mediates mucin production stimulated by p40, a Lactobacillus rhamnosus GG-derived protein","volume":"289","author":"Wang","year":"2014","journal-title":"J Biol Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0014-5793(98)00134-3","article-title":"Molecular cloning and tissue expression of porcine beta-defensin-1","volume":"424","author":"Zhang","year":"1998","journal-title":"Febs Lett."},{"key":"B40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1600-065X.2011.01081.x","article-title":"Innate immune signaling in defense against intestinal microbes","volume":"245","author":"Kinnebrew","year":"2012","journal-title":"Immunol Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"E9869","DOI":"10.1073\/pnas.1805298115","article-title":"Natural molecules induce and synergize to boostexpression of the human antimicrobial peptide beta-defensin-3","volume":"115","author":"Sechet","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"B42","doi-asserted-by":"publisher","first-page":"823710","DOI":"10.4061\/2010\/823710","article-title":"Peyer's patches: the immune sensors of the intestine","volume":"2010","author":"Jung","year":"2010","journal-title":"Int J Inflamm."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e2836","DOI":"10.1038\/cddis.2017.67","article-title":"Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity","volume":"8","author":"Bhat","year":"2017","journal-title":"Cell Death Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3389\/fimmu.2017.01629","article-title":"M(IL-4) tissue macrophages support efficient interferon-gamma production in antigen-specific CD8(+) T cells with reduced proliferative capacity","volume":"8","author":"Mulder","year":"2017","journal-title":"Front Immunol."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.00042\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T23:39:24Z","timestamp":1581032364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.00042\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":44,"alternative-id":["10.3389\/fvets.2020.00042"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2020.00042","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,7]]},"article-number":"42"}}