{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:06Z","timestamp":1791081966361,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2020.00211","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T04:34:32Z","timestamp":1587443672000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Dynamic ROS Production and Gene Expression of Heifers Blood Neutrophil in a Oligofructose Overload Model"],"prefix":"10.3389","volume":"7","author":[{"given":"Shuaichen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abid","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuepeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3168\/jds.2008-1271","article-title":"Oligofructose overload induces lameness in cattle","volume":"92","author":"Danscher","year":"2009","journal-title":"J Dairy Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.4142\/jvs.2014.15.2.217","article-title":"Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers","volume":"15","author":"Concha","year":"2014","journal-title":"J Vet Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5452","DOI":"10.1038\/s41598-019-42007-1","article-title":"Metabolic disturbances in synovial fluid are involved in the onset of synovitis in heifers with acute ruminal acidosis","volume":"9","author":"Alarcon","year":"2019","journal-title":"Sci Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cvfa.2017.06.003","article-title":"Diagnosis and treatment of clinical rumen acidosis","volume":"33","author":"Snyder","year":"2017","journal-title":"Vet Clin N Am Food A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3168\/jds.2008-1389","article-title":"A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation","volume":"92","author":"Khafipour","year":"2009","journal-title":"J Dairy Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3168\/jds.2016-10871","article-title":"Lipopolysaccharide derived from the digestive tract provokes oxidative stress in the liver of dairy cows fed a high-grain diet","volume":"100","author":"Abaker","year":"2017","journal-title":"J Dairy Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12917-018-1463-7","article-title":"Inflammatory mechanism of rumenitis in dairy cows with subacute ruminal acidosis","volume":"14","author":"Zhao","year":"2018","journal-title":"BMC Vet Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.3168\/jds.2014-8811","article-title":"Prepartal dietary energy level affects peripartal bovine blood neutrophil metabolic, antioxidant, and inflammatory gene expression","volume":"98","author":"Zhou","year":"2015","journal-title":"J Dairy Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3389\/fimmu.2017.00975","article-title":"d (-) Lactic acid-induced adhesion of bovine neutrophils onto endothelial cells is dependent on neutrophils extracellular traps formation and CD11b expression","volume":"8","author":"Alarcon","year":"2017","journal-title":"Front Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3168\/jds.S0022-0302(89)79081-0","article-title":"A body condition scoring chart for holstein dairy cows","volume":"72","author":"Edmonson","year":"1989","journal-title":"J Dairy Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cvfa.2007.04.002","article-title":"Acidosis in feedlot cattle","volume":"23","author":"Nagaraja","year":"2007","journal-title":"Vet Clin N Am-Food A."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.3168\/jds.2014-8199","article-title":"Differences in leukocyte profile, gene expression, and metabolite status of dairy cows with or without sole ulcers","volume":"98","author":"O'Driscoll","year":"2015","journal-title":"J Dairy Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.3168\/jds.2016-12025","article-title":"Supplemental methionine, choline, or taurine alter in vitro gene network expression of polymorphonuclear leukocytes from neonatal Holstein calves","volume":"100","author":"Abdelmegeid","year":"2017","journal-title":"J Dairy Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jevs.2013.01.001","article-title":"Inflammatory cytokine gene expression in blood during the development of oligofructose-induced laminitis in horses","volume":"33","author":"Tadros","year":"2013","journal-title":"J Equine Vet Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1 alpha and IL-1 beta recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jevs.2014.12.014","article-title":"Effects of high-sugar and high-starch diets on postprandial inflammatory protein concentrations in horses","volume":"35","author":"Suagee","year":"2015","journal-title":"J Equine Vet Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12917-019-1974-x","article-title":"Pro-inflammatory mediators and neutrophils are increased in synovial fluid from heifers with acute ruminal acidosis","volume":"15","author":"Hidalgo","year":"2019","journal-title":"BMC Vet Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.2527\/2000.78123155x","article-title":"Evaluation of models of acute and subacute acidosis on dry matter intake, ruminal fermentation, blood chemistry, and endocrine profiles of beef steers","volume":"78","author":"Brown","year":"2000","journal-title":"J Anim Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.2527\/jas.2008-1165","article-title":"Effects of nutritionally induced metabolic acidosis with or without glutamine infusion on acid-base balance, plasma amino acids, and plasma nonesterified fatty acids in sheep","volume":"87","author":"Odongo","year":"2009","journal-title":"J Anim Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s00441-018-2789-y","article-title":"Bovine neutrophils in health and disease","volume":"371","author":"Bassel","year":"2018","journal-title":"Cell Tissue Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.3168\/jds.2017-12896","article-title":"Subacute ruminal acidosis affects fermentation and endotoxin concentration in the rumen and relative expression of the CD14\/TLR4\/MD2 genes involved in lipopolysaccharide systemic immune response in dairy cows","volume":"101","author":"Stefanska","year":"2018","journal-title":"J Dairy Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.vetimm.2008.11.009","article-title":"Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis","volume":"129","author":"Bailey","year":"2009","journal-title":"Vet Immunol Immunopathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.livsci.2010.06.009","article-title":"Acute phase protein response during acute ruminal acidosis in cattle","volume":"135","author":"Danscher","year":"2011","journal-title":"Livest Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.vetimm.2011.07.012","article-title":"D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils","volume":"144","author":"Alarcon","year":"2011","journal-title":"Vet Immunol Immunopathol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1051\/vetres:2003024","article-title":"The bovine neutrophil. Structure and function in blood and milk","volume":"34","author":"Paape","year":"2003","journal-title":"Vet Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.vetimm.2006.09.009","article-title":"Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species","volume":"115","author":"Rinaldi","year":"2007","journal-title":"Vet Immunol Immunopathol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.tvjl.2007.07.030","article-title":"Differential alterations in the ability of bovine neutrophils to generate extracellular and intracellular reactive oxygen species during the periparturient period","volume":"178","author":"Rinaldi","year":"2008","journal-title":"Vet J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"38.8","DOI":"10.1096\/fasebj.25.1_supplement.38.8","article-title":"Neutrophils harvested from the blood of dairy cows have impaired reactive oxygen species production and release of extracellular traps during the periparturient period","volume":"25","author":"Revelo","year":"2011","journal-title":"FASEB J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40104-017-0163-7","article-title":"Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn, Mn, and Cu from amino acid complexes and Co from Co glucoheptonate","volume":"8","author":"Batistel","year":"2017","journal-title":"J Anim Sci Biotechnol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases. role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid Redox Signal."},{"key":"B32","doi-asserted-by":"publisher","first-page":"8146","DOI":"10.3168\/jds.2018-14428","article-title":"Maternal supply of methionine during late pregnancy is associated with changes in immune function and abundance of microRNA and mRNA in Holstein calf polymorphonuclear leukocytes","volume":"101","author":"Jacometo","year":"2018","journal-title":"J Dairy Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"10374","DOI":"10.3168\/jds.2018-14972","article-title":"Methionine and choline supply during the peripartal period alter polymorphonuclear leukocyte immune response and immunometabolic gene expression in Holstein cows","volume":"101","author":"Zhou","year":"2018","journal-title":"J Dairy Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3168\/jds.2018-15356","article-title":"Distinct neutrophil C5a receptor inflammatory events in cows initiated by chemoattractant C5a and lipopolysaccharide around parturition and in mid lactation","volume":"102","author":"Boulougouris","year":"2019","journal-title":"J Dairy Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3389\/fmed.2018.00134","article-title":"Myeloperoxidase negatively regulates neutrophil-endothelial cell interactions by impairing alpha M beta 2 integrin function in sterile inflammation","volume":"5","author":"Tseng","year":"2018","journal-title":"Front Med."},{"key":"B36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/BF03548327","article-title":"Endotoxin and arachidonic acid metabolites in portal, hepatic and arterial blood of cattle with acute ruminal acidosis","volume":"35","author":"Andersen","year":"1994","journal-title":"Acta Vet Scand."},{"key":"B37","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4142\/jvs.2015.16.4.405","article-title":"Stress and pain response after oligofructose induced-lameness in dairy heifers","volume":"16","author":"Bustamante","year":"2015","journal-title":"J Vet Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.vetimm.2007.04.002","article-title":"Transportation stress in young bulls alters expression of neutrophil genes important for the regulation of apoptosis, tissue remodeling, margination, and anti-bacterial function","volume":"118","author":"Sporer","year":"2007","journal-title":"Vet Immunol Immunopathol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.vetimm.2007.10.010","article-title":"Transportation stress alters the circulating steroid environment and neutrophil gene expression in beef bulls","volume":"121","author":"Sporer","year":"2008","journal-title":"Vet Immunol Immunopathol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.vetimm.2005.02.012","article-title":"Gene expression signatures in neutrophils exposed to glucocorticoids. A new paradigm to help explain \u201cneutrophil dysfunction\u201d in parturient dairy cows","volume":"105","author":"Burton","year":"2005","journal-title":"Vet Immunol Immunopathol."},{"key":"B41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.56808\/2985-1130.2863","article-title":"Effects of induced subacute ruminal acidosis and laminitis on lipopolysaccharide binding protein, cortisol and progesterone levels in dairy heifers","volume":"47","author":"Seesupa","year":"2017","journal-title":"Thai J Vet Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e0137221","DOI":"10.1371\/journal.pone.0137221","article-title":"Extracellular acidification acts as a key modulator of neutrophil apoptosis and functions","volume":"10","author":"Cao","year":"2015","journal-title":"PLoS ONE."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.3168\/jds.2009-2922","article-title":"Effects of in vitro insulin and 2,4-thiazolidinedione on the function of neutrophils harvested from blood of cows in different physiological states","volume":"93","author":"Revelo","year":"2010","journal-title":"J Dairy Sci."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.00211\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T04:38:53Z","timestamp":1696048733000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.00211\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":43,"alternative-id":["10.3389\/fvets.2020.00211"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2020.00211","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]},"article-number":"211"}}