{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:18:02Z","timestamp":1784830682424,"version":"3.55.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2020.00336","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T11:47:35Z","timestamp":1593517655000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Histochemical and Immunohistochemical Characterizations of Hepatic Trematodiasis in Odontocetes"],"prefix":"10.3389","volume":"7","author":[{"given":"Shotaro","family":"Nakagun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1136\/vr.130.26.569","article-title":"Causes of mortality and parasites and incidental lesions in dolphins and whales from British waters","volume":"130","author":"Baker","year":"1992","journal-title":"Vet Rec"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0204444","DOI":"10.1371\/journal.pone.0204444","article-title":"Pathologic findings and causes of death of stranded cetaceans in the Canary Islands (2006\u20132012)","volume":"13","author":"D\u00edaz-Delgado","year":"2018","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"795","DOI":"10.7589\/2016-07-150","article-title":"Postmortem findings in cetaceans found stranded in the Pelagos Sanctuary, Italy, 2007\u201314","volume":"53","author":"Giorda","year":"2017","journal-title":"J Wildl Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1292\/jvms.18-0706","article-title":"Surveillance of amyloidosis in stranded and bycaught cetaceans off Hokkaido, Japan","volume":"81","author":"Nakagun","year":"2019","journal-title":"J Vet Med Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1177\/030098586900600307","article-title":"Some parasitic diseases of dolphins","volume":"6","author":"Woodard","year":"1969","journal-title":"Pathol Vet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"503","DOI":"10.7589\/0090-3558-14.4.503","article-title":"Parasites and associated pathology observed in cetaceans stranded along the Oregon coast","volume":"14","author":"Dailey","year":"1978","journal-title":"J Wildl Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1177\/0300985816642228","article-title":"Verminous arteritis due to Crassicauda sp. in Cuvier's beaked whales (Ziphius cavirostris)","volume":"53","author":"D\u00edaz-Delgado","year":"2016","journal-title":"Vet Pathol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1139\/f78-210","article-title":"Parasitic mastitis in the Atlantic white-sided dolphin, Lagenorhynchus acutus, as a probable factor in herd productivity","volume":"35","author":"Geraci","year":"1978","journal-title":"J Fish Res Board Can"},{"key":"B9","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2307\/1380889","article-title":"Disease of the common fin whale (Balaenoptera physalus) \u2013 crassicaudiosis of the urinary system","volume":"67","author":"Lambertsen","year":"1986","journal-title":"J Mammal"},{"key":"B10","first-page":"678","article-title":"Parasites","volume-title":"Encyclopedia of Marine Mammals","author":"Raga","year":"2017"},{"key":"B11","first-page":"821","article-title":"Parasite","volume-title":"Encyclopedia of Marine Mammals","author":"Raga","year":"2008"},{"key":"B12","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0020-7519(87)90116-0","article-title":"Effects of parasites on marine mammals","volume":"17","author":"Geraci","year":"1987","journal-title":"Int J Parasitol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3354\/dao02630","article-title":"Biliary cirrhosis caused by Campula spp. in a dolphin and four porpoises","volume":"106","author":"Jaber","year":"2013","journal-title":"Dis Aquat Organ."},{"key":"B14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1096-3642.1856.tb00090.x","article-title":"Observations on Entozoa, with notices of several new species, including an account of two experiments in regard to the breeding of Taenia serrata and T. Cucumerina","volume":"22","author":"Cobbold","year":"1858","journal-title":"Trans Linn Soc Lond"},{"key":"B15","doi-asserted-by":"publisher","first-page":"160","DOI":"10.7589\/0090-3558-21.2.160","article-title":"Parasites of the Dall's porpoise (Phocoenoides dalli True)","volume":"21","author":"Conlogue","year":"1985","journal-title":"J Wildl Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"593","DOI":"10.2307\/3279939","article-title":"Parasitism as a factor (?","volume":"64","author":"Dailey","year":"1978","journal-title":". J Parasitol"},{"key":"B17","first-page":"283","article-title":"Studies on the helminth fauna of Japan. part 45. Trematodes of marine mammals","volume":"7","author":"Yamaguti","year":"1951","journal-title":"Arb Med Fak Okayama"},{"key":"B18","first-page":"83","article-title":"Parasitic helminth and epizoit fauna of finless porpoise in the Inland Sea of Japan and the western North Pacific with a preliminary note on faunal difference by host's local population","volume":"33","author":"Kuramochi","year":"2000","journal-title":"Mem Natn Sci Mus Tokyo"},{"key":"B19","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1292\/jvms.16-0421","article-title":"Population and growth-related differences in helminthic fauna of finless porpoises (Neophocaena asiaeorientalis) in five Japanese populations","volume":"79","author":"Shiozaki","year":"2017","journal-title":"J Vet Med Sci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2307\/3284507","article-title":"Occurrence and morphological comparisons of Campula oblonga (Digenea: Campulidae), including a report from an atypical host, the thresher shark, Alopias vulpinus","volume":"84","author":"Adams","year":"1998","journal-title":"J Parasitol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/j.1469-7998.1998.tb00061.x","article-title":"A survey of the helminth parasites of cetaceans stranded on the coast of England and Wales during the period 1990\u20131994","volume":"244","author":"Gibson","year":"1998","journal-title":"J Zool Lond."},{"key":"B22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1354\/vp.41-2-147","article-title":"Hepatic lesions in cetaceans stranded in the Canary Islands","volume":"41","author":"Jaber","year":"2004","journal-title":"Vet Pathol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1053\/jcpa.2001.0547","article-title":"Post-mortem findings and causes of death of harbour porpoises (Phocoena phocoena) stranded from 1990 to 2000 along the coastlines of Belgium and Northern France","volume":"126","author":"Jauniaux","year":"2002","journal-title":"J Comp Pathol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1053\/jcpa.2000.0436","article-title":"Post-mortem findings in harbour porpoises (Phocoena phocoena) from the German North and Baltic Seas","volume":"124","author":"Siebert","year":"2001","journal-title":"J Comp Pathol"},{"key":"B25","first-page":"183","article-title":"Oschmarinella macrorchis sp. n. (Digenea: Campulidae) from the liver sinuses of a beaked whale, Mesoplodon stejnegeri (Cetacea: Ziphiidae)","volume":"64","author":"Demaree","year":"1997","journal-title":"J Helminthol Soc Wash"},{"key":"B26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3354\/dao03201","article-title":"Prominent hepatic ductular reaction induced by Oschmarinella macrorchis in a Hubbs' beaked whale Mesoplodon carlhubbsi, with biological notes","volume":"127","author":"Nakagun","year":"2018","journal-title":"Dis Aquat Organ"},{"key":"B27","first-page":"533","article-title":"Common diseases of small cetaceans","volume":"167","author":"Sweeney","year":"1975","journal-title":"J Am Vet Med Assoc"},{"key":"B28","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.vetpar.2011.05.014","article-title":"Parasites of cetaceans stranded on the Pacific coast of Costa Rica","volume":"182","author":"Oliveira","year":"2011","journal-title":"Vet Parasitol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis \u2013 from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"J Hepatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest."},{"key":"B31","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cld.2008.07.002","article-title":"Immune interactions in hepatic fibrosis","volume":"12","author":"Holt","year":"2008","journal-title":"Clin Liver Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S0021-9975(03)00008-2","article-title":"Immunophenotypic characterization of hepatic inflammatory cell infiltrates in common dolphins","volume":"129","author":"Jaber","year":"2003","journal-title":"J Comp Pathol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.rvsc.2013.05.011","article-title":"Immunopathological study of parasitic cholangitis in cetaceans","volume":"95","author":"Jaber","year":"2013","journal-title":"Res Vet Sci"},{"key":"B34","first-page":"592","volume-title":"Marine Mammals of the World: a Comprehensive Guide to Their Identification.","author":"Jefferson","year":"2008"},{"key":"B35","first-page":"371","volume-title":"Marine Mammals Ashore: A Field Guide for Strandings","author":"Geraci","year":"2005"},{"key":"B36","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0020-7519(98)00027-7","article-title":"Molecular phylogeny of the families Campulidae and Nasitrematidae (Trematoda) based on mtDNA sequence comparison","volume":"28","author":"Fern\u00e1ndez","year":"1998","journal-title":"Int J Parasitol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1645\/0022-3395(","article-title":"The origin of Lecithodesmus (Digenea: Campulidae) based on ND3 gene comparison","volume":"86","author":"Fern\u00e1ndez","year":"2000","journal-title":"J Parasitol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.parint.2015.12.009","article-title":"Evolutionary relationships between digeneans of the family Brachycladiidae Odhner, 1905 and their marine mammal hosts: a cophylogenetic study","volume":"65","author":"Fraija-Fern\u00e1ndez","year":"2016","journal-title":"Parasitol Int"},{"key":"B39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0006-8993(80)90071-2","article-title":"Experimental allergic neuritis. I. rat strain differences in the response to bovine myelin antigens","volume":"195","author":"Hoffman","year":"1980","journal-title":"Brain Res"},{"key":"B40","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat","volume":"65","author":"Kountouras","year":"1984","journal-title":"Br J Exp Pathol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1053\/j.semdp.2006.11.006","article-title":"Special stains in diagnostic liver pathology","volume":"23","author":"Lefkowitch","year":"2006","journal-title":"Semin Diagn Pathol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/s12879-017-2630-3","article-title":"Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection","volume":"17","author":"Han","year":"2017","journal-title":"BMC Infect Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1136\/vr.159.13.410","article-title":"Pathological and immunohistochemical study of gastrointestinal lesions in dolphins stranded in the Canary Islands","volume":"159","author":"Jaber","year":"2006","journal-title":"Vet Rec"},{"key":"B44","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.rvsc.2015.03.021","article-title":"Immunohistochemical characterisation of parasitic pneumonias of dolphins stranded in the Canary Islands","volume":"100","author":"Zafra","year":"2015","journal-title":"Res Vet Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14252\/foodsafetyfscj.2016012","article-title":"Histopathological analysis of rat hepatotoxicity based on macrophage functions: in particular, an analysis for thioacetamide-induced hepatic lesions","volume":"4","author":"Yamate","year":"2016","journal-title":"Food Saf"},{"key":"B47","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1292\/jvms.12-0536","article-title":"Immunohistochemical characterization of macrophages and myofibroblasts in fibrotic liver lesions due to Fasciola infection in cattle","volume":"75","author":"Golbar","year":"2013","journal-title":"J Vet Med Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13567-018-0550-x","article-title":"Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection","volume":"49","author":"Pacheco","year":"2018","journal-title":"Vet Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/vr.105562","article-title":"Stress cardiomyopathy in stranded cetaceans: a histological, histochemical and immunohistochemical study","volume":"185","author":"C\u00e2mara","year":"2019","journal-title":"Vet Rec"},{"key":"B50","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.tvjl.2012.09.021","article-title":"Capture myopathy in live-stranded cetaceans","volume":"196","author":"Herr\u00e1ez","year":"2013","journal-title":"Vet J"},{"key":"B51","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1177\/0300985816660747","article-title":"Muscle pathology in free-ranging stranded cetaceans","volume":"54","author":"Sierra","year":"2017","journal-title":"Vet Pathol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1139\/f95-118","article-title":"Variability of the mitochondrial control region in populations of the harbour porpoise, Phocoena, on interoceanic and regional scales","volume":"52","author":"Rosel","year":"1995","journal-title":"Can J Fish Aquat Sci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1292\/jvms.66.671","article-title":"Distributive and phagocytic characteristics of hepatic macrophages in five cetaceans belonging to Delphinidae and Ziphiidae","volume":"66","author":"Kawashima","year":"2004","journal-title":"J Vet Med Sci"},{"key":"B54","first-page":"926","article-title":"Hepatic trematodiasis in a Ganges River dolphin","volume":"175","author":"Migaki","year":"1979","journal-title":"J Am Vet Med Assoc"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.00336\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T11:47:41Z","timestamp":1593517661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.00336\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":54,"alternative-id":["10.3389\/fvets.2020.00336"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2020.00336","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]},"article-number":"336"}}