{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:02:53Z","timestamp":1773705773285,"version":"3.50.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2020.536390","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T04:34:31Z","timestamp":1600749271000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Expression of Viral microRNAs in Serum and White Blood Cells of Cows Exposed to Bovine Leukemia Virus"],"prefix":"10.3389","volume":"7","author":[{"given":"Eduardo","family":"Casas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Lippolis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"346","DOI":"10.2460\/javma.2003.223.346","article-title":"Economic implications of bovine leukemia virus infection in mid-Atlantic dairy herds","volume":"223","author":"Rhodes","year":"2003","journal-title":"J Am Vet Med Assoc"},{"key":"B2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.vetimm.2014.11.014","article-title":"Bovine leukemia virus: a major silent threat to proper immune responses in cattle","volume":"163","author":"Frie","year":"2015","journal-title":"Vet Immunol Immunopathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1177\/1040638717702183","article-title":"Bovine leukemia virus seroprevalence among cattle presented for slaughter in the United States","volume":"29","author":"Bauermann","year":"2017","journal-title":"J Vet Diagn Invest"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.3168\/jds.2012-5930","article-title":"Bovine leukemia virus and cow longevity in Michigan dairy herds","volume":"96","author":"Bartlett","year":"2013","journal-title":"J Dairy Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1152\/physiolgenomics.00081.2006","article-title":"Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues","volume":"29","author":"Coutinho","year":"2007","journal-title":"Physiol Genomics"},{"key":"B6","doi-asserted-by":"publisher","first-page":"E21","DOI":"10.2527\/jas.2008-1303","article-title":"MicroRNA: mechanism of gene regulation and application to livestock","volume":"87","author":"McDaneld","year":"2009","journal-title":"J Anim Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","article-title":"MicroRNAs: synthesis, mechanism, function, and recent clinical trials","volume":"1803","author":"Wahid","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"B8","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3389\/fgene.2015.00240","article-title":"MicroRNAs as clinical biomarkers?","volume":"6","author":"Angelini","year":"2015","journal-title":"Front Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/jcp.25056","article-title":"MicroRNA as biomarkers and diagnostics","volume":"231","author":"Wang","year":"2016","journal-title":"J Cell Physiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fvets.2016.00022","article-title":"Small non-coding RNAs associated with viral infectious diseases of veterinary importance: potential clinical applications","volume":"3","author":"Samir","year":"2016","journal-title":"Front Vet Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fvets.2016.00086","article-title":"MicroRNAs in the host response to viral infections of veterinary importance","volume":"3","author":"Samir","year":"2016","journal-title":"Front Vet Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fimmu.2017.00118","article-title":"Circulating microRNAs as potential biomarkers of infectious disease","volume":"8","author":"Correia","year":"2017","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0161651","DOI":"10.1371\/journal.pone.0161651","article-title":"Association of MicroRNAs with antibody response to mycoplasma bovis in beef cattle","volume":"11","author":"Casas","year":"2016","journal-title":"PLoS ONE"},{"key":"B14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fgene.2017.00091","article-title":"Circulating MicroRNAs in serum from cattle challenged with bovine viral diarrhea virus","volume":"8","author":"Taxis","year":"2017","journal-title":"Front Genet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1079\/PAVSNNR201712026","article-title":"MicroRNA expression and implications for infectious diseases in livestock","volume":"12","author":"Taxis","year":"2017","journal-title":"CAB Reviews"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1073\/pnas.1116107109","article-title":"RNA virus microRNA that mimics a B-cell oncomiR","volume":"109","author":"Kincaid","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1073\/pnas.1213842110","article-title":"Deep sequencing reveals abundant noncanonical retroviral microRNAs in B-cell leukemia\/lymphoma","volume":"110","author":"Rosewick","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12977-016-0267-8","article-title":"Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals constitutive expression in tumors and transcriptional interaction with viral microRNAs","volume":"13","author":"Durkin","year":"2016","journal-title":"Retrovirology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e1005588","DOI":"10.1371\/journal.ppat.1005588","article-title":"Bovine leukemia virus small noncoding RNAs are functional elements that regulate replication and contribute to oncogenesis in vivo","volume":"12","author":"Gillet","year":"2016","journal-title":"PLoS Pathog"},{"key":"B20","doi-asserted-by":"publisher","first-page":"31125","DOI":"10.1038\/srep31125","article-title":"Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the bovine leukemia virus genome","volume":"6","author":"Van Driessche","year":"2016","journal-title":"Sci Rep"},{"key":"B21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3389\/fvets.2017.00245","article-title":"MicroRNAs Encoded by Bovine Leukemia Virus (BLV) are associated with reduced expression of B cell transcriptional regulators in dairy cattle naturally infected with BLV","volume":"4","author":"Frie","year":"2017","journal-title":"Front Vet Sci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3389\/fgene.2018.00236","article-title":"Association of transfer RNA fragments in white blood cells with antibody response to bovine leukemia virus in holstein cattle","volume":"9","author":"Taxis","year":"2018","journal-title":"Front Genet."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.12688\/f1000research.15931.2","article-title":"FastQ Screen: a tool for multi-genome mapping and quality control","volume":"7","author":"Wingett","year":"2018","journal-title":"F1000Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2018","journal-title":"EMBnetjournal"},{"key":"B25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/gkr688","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"40","author":"Friedlander","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"Enright","year":"2003","journal-title":"Genome Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1038\/ng2135","article-title":"The role of site accessibility in microRNA target recognition","volume":"39","author":"Kertesz","year":"2007","journal-title":"Nat Genet"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e01261","DOI":"10.1128\/JVI.01261-18","article-title":"Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium","volume":"92","author":"Kang","year":"2018","journal-title":"J Virol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1158\/1078-0432.CCR-16-0594","article-title":"Survival of Del17p CLL depends on genomic complexity and somatic mutation","volume":"23","author":"Yu","year":"2017","journal-title":"Clin Cancer Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.2147\/OTT.S193616","article-title":"Proteomic analysis of cerebrospinal fluid in pediatric acute lymphoblastic leukemia patients: a pilot study","volume":"12","author":"Guo","year":"2019","journal-title":"Onco Targets Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1038\/s41598-018-20957-2","article-title":"Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2\/4 axis and innate immunity in gastric diseases","volume":"8","author":"Chang","year":"2018","journal-title":"Sci Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1615\/critrevimmunol.v28.i6.30","article-title":"Toll-like receptor family in domestic animal species","volume":"28","author":"Turin","year":"2008","journal-title":"Crit Rev Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.rvsc.2016.06.016","article-title":"Toll-like receptors, IFN-gamma and IL-12 expression in bovine leukemia virus-infected animals with low or high proviral load","volume":"107","author":"Farias","year":"2016","journal-title":"Res Vet Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"197678","DOI":"10.1016\/j.virusres.2019.197678","article-title":"Effect of bovine leukemia virus on bovine mammary epithelial cells","volume":"271","author":"Martinez Cuesta","year":"2019","journal-title":"Virus Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nri1529","article-title":"WNT signalling and haematopoiesis: a WNT-WNT situation","volume":"5","author":"Staal","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1038\/bcj.2014.12","article-title":"Deregulated WNT signaling in childhood T-cell acute lymphoblastic leukemia","volume":"4","author":"Ng","year":"2014","journal-title":"Blood Cancer J"},{"key":"B38","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1186\/1471-2105-16-S4-S4","article-title":"An integrated approach of gene expression and DNA-methylation profiles of WNT signaling genes uncovers novel prognostic markers in acute myeloid leukemia","volume":"16","author":"Taskesen","year":"2015","journal-title":"BMC Bioinformatics."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1182\/blood-2017-06-743252","article-title":"Philadelphia chromosome-like acute lymphoblastic leukemia","volume":"130","author":"Tasian","year":"2017","journal-title":"Blood"},{"key":"B40","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3390\/cancers10110436","article-title":"Focal adhesion genes refine the intermediate-risk cytogenetic classification of acute myeloid leukemia","volume":"10","author":"Pallares","year":"2018","journal-title":"Cancers."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.cellsig.2011.06.010","article-title":"The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein","volume":"23","author":"Jin","year":"2011","journal-title":"Cell Signal"},{"key":"B42","doi-asserted-by":"publisher","first-page":"6837","DOI":"10.1182\/blood-2010-07-295725","article-title":"Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease","volume":"117","author":"Ren","year":"2011","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.3324\/haematol.2015.137695","article-title":"FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model","volume":"101","author":"Qin","year":"2016","journal-title":"Haematologica"},{"key":"B44","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ebiom.2019.05.025","article-title":"LGALS3 is connected to CD74 in a previously unknown protein network that is associated with poor survival in patients with AML","volume":"44","author":"Ruvolo","year":"2019","journal-title":"EBioMedicine"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ebiom.2019.05.051","article-title":"Alliance of galectin-3 and CD74 biochemical networks as a crucial component of survival machinery operated by human acute myeloid leukaemia cells","volume":"44","author":"Yasinska","year":"2019","journal-title":"EBioMedicine"},{"key":"B46","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/bjh.13995","article-title":"A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells","volume":"174","author":"Medves","year":"2016","journal-title":"Br J Haematol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1186\/s12885-015-1549-6","article-title":"Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes","volume":"15","author":"Spinella","year":"2015","journal-title":"BMC Cancer"},{"key":"B48","doi-asserted-by":"publisher","first-page":"16527","DOI":"10.18632\/oncotarget.4113","article-title":"A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"B49","doi-asserted-by":"publisher","first-page":"E10137","DOI":"10.1073\/pnas.1806019115","article-title":"Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches","volume":"115","author":"Das","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1373\/clinchem.2003.030114","article-title":"Differentiation of acute myeloid leukemia from B- and T-lineage acute lymphoid leukemias by real-time quantitative reverse transcription-PCR of lineage marker mRNAs","volume":"50","author":"Saussoy","year":"2004","journal-title":"Clin Chem"},{"key":"B51","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3324\/haematol.2015.123711","article-title":"Resimmune, an anti-CD3epsilon recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma","volume":"100","author":"Frankel","year":"2015","journal-title":"Haematologica"},{"key":"B52","doi-asserted-by":"publisher","first-page":"9413","DOI":"10.3892\/ol.2018.8504","article-title":"Screening for susceptibility genes in hereditary non-polyposis colorectal cancer","volume":"15","author":"Yu","year":"2018","journal-title":"Oncol Lett"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e304","DOI":"10.1212\/NXG.0000000000000304","article-title":"Gene variants of adhesion molecules predispose to MS: a case-control study","volume":"5","author":"Dardiotis","year":"2019","journal-title":"Neurol Genet"},{"key":"B54","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s12881-018-0593-x","article-title":"A case of Raine syndrome presenting with facial dysmorphy and review of literature","volume":"19","author":"Sheth","year":"2018","journal-title":"BMC Med Genet"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.536390\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T04:34:32Z","timestamp":1600749272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fvets.2020.536390\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":54,"alternative-id":["10.3389\/fvets.2020.536390"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2020.536390","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]},"article-number":"536390"}}