{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:50:52Z","timestamp":1788274252630,"version":"build-2803163510"},"reference-count":161,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Feral swine (<jats:italic>Sus scrofa<\/jats:italic>) are a destructive invasive species widespread throughout the United States that disrupt ecosystems, damage crops, and carry pathogens of concern for the health of domestic stock and humans including<jats:italic>Brucella suis<\/jats:italic>\u2014the causative organism for swine brucellosis. In domestic swine, brucellosis results in reproductive failure due to abortions and infertility. Contact with infected feral swine poses spillover risks to domestic pigs as well as humans, companion animals, wildlife, and other livestock. Genetic factors influence the outcome of infectious diseases; therefore, genome wide association studies (GWAS) of differential immune responses among feral swine can provide an understanding of disease dynamics and inform management to prevent the spillover of brucellosis from feral swine to domestic pigs. We sought to identify loci associated with differential antibody responses among feral swine naturally infected with<jats:italic>B. suis<\/jats:italic>using a case-control GWAS. Tissue, serum, and genotype data (68,516 bi-allelic single nucleotide polymorphisms) collected from 47 feral swine were analyzed in this study. The 47 feral swine were culture positive for<jats:italic>Brucella<\/jats:italic>spp. Of these 47, 16 were antibody positive (cases) whereas 31 were antibody negative (controls). Single-locus GWAS were performed using efficient mixed-model association eXpedited (EMMAX) methodology with three genetic models: additive, dominant, and recessive. Eight loci associated with seroconversion were identified on chromosome 4, 8, 9, 10, 12, and 18. Subsequent bioinformatic analyses revealed nine putative candidate genes related to immune function, most notably phagocytosis and induction of an inflammatory response. Identified loci and putative candidate genes may play an important role in host immune responses to<jats:italic>B. suis<\/jats:italic>infection, characterized by a detectable bacterial presence yet a differential antibody response. Given that antibody tests are used to evaluate brucellosis infection in domestic pigs and for disease surveillance in invasive feral swine, additional studies are needed to fully understand the genetic component of the response to<jats:italic>B. suis<\/jats:italic>infection and to more effectively translate estimates of<jats:italic>Brucella<\/jats:italic>spp. antibody prevalence among feral swine to disease control management action.<\/jats:p>","DOI":"10.3389\/fvets.2020.554674","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T09:36:35Z","timestamp":1606296995000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Loci Associated With Antibody Response in Feral Swine (Sus scrofa) Infected With Brucella suis"],"prefix":"10.3389","volume":"7","author":[{"given":"Courtney F.","family":"Pierce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vienna R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Boggiatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan S.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Speidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Smyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1007\/s10530-019-01983-1","article-title":"Historical, current, and potential population size estimates of invasive wild pigs (Sus scrofa) in the United States","volume":"21","author":"Lewis","year":"2019","journal-title":"Biol Invasions"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/mec.15392","article-title":"Rapid expansion of an invasive ungulate driven by bridgehead populations of admixed wild and domestic lineages","volume":"29","author":"Smyser","year":"2020","journal-title":"Mol Ecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e01844","DOI":"10.1002\/ecs2.1844","article-title":"Anthropogenic factors predict movement of an invasive species","volume":"8","author":"Tabak","year":"2017","journal-title":"Ecosphere"},{"key":"B4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.7589\/2017-04-071","article-title":"Evidence of pseudorabies virus shedding in feral swine (Sus scrofa) populations of Florida, USA","volume":"4","author":"Hern\u00e1ndez","year":"2018","journal-title":"J Wildl Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cropro.2016.06.023","article-title":"Economic estimates of feral swine damage and control in 11 US states","volume":"89","author":"Anderson","year":"2016","journal-title":"Crop Prot"},{"key":"B6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.agee.2015.12.027","article-title":"Plant community shifts caused by feral swine rooting devalue Florida rangeland","volume":"15","author":"Bankovich","year":"2016","journal-title":"Agric Ecosyst Environ"},{"key":"B7","unstructured":"HuttonT DelibertoT OwenS MorrisonB Disease Risks Associated with Increasing Feral Swine Numbers and Distribution in the United States2006"},{"key":"B8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1093\/biosci\/biu015","article-title":"Consequences associated with the recent range expansion of nonnative feral swine","volume":"64","author":"Bevins","year":"2014","journal-title":"BioScience"},{"key":"B9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/zph.12359","article-title":"Identification of Brucella spp. in feral swine (Sus scrofa) at abattoirs in Texas, USA","volume":"64","author":"Pedersen","year":"2017","journal-title":"Zoonoses Public Health"},{"key":"B10","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.prevetmed.2011.04.007","article-title":"Brucellosis at the animal\/ecosystem\/human interface at the beginning of the 21st century","volume":"102","author":"Godfroid","year":"2011","journal-title":"Prev Vet Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.it.2017.03.006","article-title":"Patterns, receptors, and signals: Regulation of phagosome maturation","volume":"38","author":"Pauwels","year":"2017","journal-title":"Trends in Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/microbiolspec.BAI-0006-2019","article-title":"The intracellular lifecycle of Brucella spp","volume":"7","author":"Celli","year":"2019","journal-title":"Microbiol Spectr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/j.1462-5822.2010.01499.x","article-title":"Type IV secretion systems: versatility and diversity in function","volume":"12","author":"Wallden","year":"2010","journal-title":"Cell Microbiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e1003556","DOI":"10.1371\/journal.ppat.1003556","article-title":"Brucella modulates secretory trafficking via multiple type IV secretion effector proteins","volume":"9","author":"Myeni","year":"2013","journal-title":"PLoS Pathog"},{"key":"B15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1177\/104063870701900301","article-title":"Diagnostic characterization of a feral swine herd enzootically infected with Brucella","volume":"19","author":"Stoffregen","year":"2007","journal-title":"J Vet Diagn Invest"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1128\/AEM.00045-12","article-title":"Molecular epidemiology of Brucella abortus isolates from cattle, elk, and bison in the United States, 1998 to 2011","volume":"78","author":"Higgins","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12917-015-0456-z","article-title":"First isolation and characterization of Brucella microti from wild boar","volume":"11","author":"R\u00f3nai","year":"2015","journal-title":"BMC Vet Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1177\/0300985814540545","article-title":"Advancement of knowledge of Brucella over the past 50 years","volume":"51","author":"Olsen","year":"2014","journal-title":"Vet Pathol"},{"key":"B19","year":"2011"},{"key":"B20","unstructured":"USDAAPHIS What Is Swine Brucellosis?2018"},{"key":"B21","first-page":"38","article-title":"Apparent prevalence of swine brucellosis in feral swine in the United States","volume":"6","author":"Pedersen","year":"2012","journal-title":"Hum-Wildl Interact"},{"key":"B22","doi-asserted-by":"publisher","first-page":"7821","DOI":"10.1038\/s41598-017-07336-z","article-title":"Cross-species transmission potential between wild pigs, livestock, poultry, wildlife, and humans: Implications for disease risk management in North America","volume":"7","author":"Miller","year":"2017","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"422","DOI":"10.7589\/0090-3558-45.2.422","article-title":"Feral swine contact with domestic swine: a serological survey and assessment of potential for disease transmission","volume":"45","author":"Wyckoff","year":"2009","journal-title":"J Wildl Dis"},{"key":"B24","unstructured":"Pork facts"},{"key":"B25","first-page":"316","article-title":"\u201cFeral swine \u2013 are they a disease threat to livestock in the United States?\u201d","volume-title":"The 10th Wildlife Damage Management Conference Proceedings: Hot Springs, AR, April 6-9","author":"Witmer","year":"2003"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/VMRR.S91360","article-title":"Swine brucellosis: current perspectives","volume":"8","author":"Olsen","year":"2017","journal-title":"Vet Med Res Rep"},{"key":"B27","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1177\/104063879700900414","article-title":"Brucella suis biovar 1 in naturally infected cattle: a bacteriological, serological, and histological study","volume":"9","author":"Ewalt","year":"1997","journal-title":"J Vet Diagn Invest"},{"key":"B28","doi-asserted-by":"publisher","first-page":"215","DOI":"10.7589\/2012-06-169","article-title":"Use of serology and bacterial culture to determine prevalence of Brucella spp","volume":"49","author":"Musser","year":"2013"},{"key":"B29","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.tmaid.2017.03.006","article-title":"Brucella suis infection associated with feral swine hunting-Three States, 2007-2008","volume":"58","author":"Giurgiutiu","year":"2009","journal-title":"MMWR Surveill Summ"},{"key":"B30","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.2460\/javma.1995.207.10.1332","article-title":"Comparison of serologic tests and bacteriologic culture for detection of brucellosis in swine from naturally infected herds","volume":"207","author":"Ferris","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"B31","doi-asserted-by":"publisher","first-page":"171","DOI":"10.7589\/2013-09-235","article-title":"Identification of Brucella suis from feral swine in selected states in the USA","volume":"50","author":"Pedersen","year":"2014","journal-title":"J Wildl Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e24853","DOI":"10.5812\/jjm.24853","article-title":"Comparison of biological and immunological characterization of Lipopolysaccharides from Brucella abortus RB51 and S19","volume":"8","author":"Kianmehr","year":"2015","journal-title":"Jundishapur J Microbiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13567-015-0147-6","article-title":"Immunoproteomic identification of immunodominant antigens independent of the time of infection in Brucella abortus 2308-challenged cattle","volume":"46","author":"Lee","year":"2015","journal-title":"Vet Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1128\/CDLI.5.6.862-870.1998","article-title":"O-Polysaccharide epitopic heterogeneity at the surface of Brucella spp. studied by enzyme-linked immunosorbent assay and flow cytometry","volume":"5","author":"Cloeckaert","year":"1998","journal-title":"Clin Diagn Lab Immunol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1515\/9780691220161-009","article-title":"Genetic variability of hosts","volume-title":"Immunology and Evolution of Infectious Disease.","author":"Frank","year":"2002"},{"key":"B36","unstructured":"Opportunities for incorporating genetic elements into the management of farm animal diseases: policy issues136 BishopSC De JongM GrayD Food and Agriculture Organization of the United Nations (FAO)Food and Agriculture Organization of the United Nations (FAO) Study Paper182002"},{"key":"B37","first-page":"288","article-title":"Disease resistance: genetics","volume-title":"Encyclopedia of Animal Science","author":"Bishop","year":"2005"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1098\/rstb.2005.1674","article-title":"Animal breeding and disease","volume":"360","author":"Nicholas","year":"2005","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2174\/1874318801004010061","article-title":"Natural resistance against brucellosis: a review","volume":"4","author":"Garry Adams","year":"2010","journal-title":"Open Vet Sci J"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.2460\/ajvr.2002.63.1598","article-title":"Comparison of serologic tests for detection of Brucella infections in cattle and water buffalo (Bubalus bubalis)","volume":"63","author":"Fosgate","year":"2002","journal-title":"Am J Vet Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0378-1135(02)00229-8","article-title":"Diagnosis of brucellosis by serology","volume":"90","author":"Nielsen","year":"2002","journal-title":"Vet Microbiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1017\/S095026880500511X","article-title":"Differentiation between serological responses to Brucella suis and Yersinia enterocolitica serotype O[ratio]9 after natural or experimental infection in pigs","volume":"134","author":"Jungersen","year":"2006","journal-title":"Epidemiol Infect"},{"key":"B43","volume-title":"Pathogenesis and Immune Responses of Heritage Breed Pigs to Experimental Inoculation with Brucella suis","author":"Brown","year":"2020"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e6524","DOI":"10.1371\/journal.pone.0006524","article-title":"Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology","volume":"4","author":"Ramos","year":"2009","journal-title":"PLoS ONE"},{"key":"B45","doi-asserted-by":"publisher","first-page":"giaa051","DOI":"10.1093\/gigascience\/giaa051","article-title":"An improved pig reference genome sequence to enable pig genetics and genomics research","volume":"9","author":"Warr","year":"2020","journal-title":"Gigascience"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: Rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"GigaScience"},{"key":"B47","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/nprot.2010.182","article-title":"Basic statistical analysis in genetic case-control studies","volume":"6","author":"Clarke","year":"2011","journal-title":"Nat Protoc"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1002822","DOI":"10.1371\/journal.pcbi.1002822","article-title":"Genome-wide association studies","volume":"8","author":"Bush","year":"2012","journal-title":"PLOS Comput Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/ng.548","article-title":"Variance component model to account for sample structure in genome-wide assocation studies","volume":"42","author":"Kang","year":"2010","journal-title":"Nature Genet"},{"key":"B50","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF02294361","article-title":"Model selection and Akaike's information criterion (AIC): the general theory and its analytical extensions","volume":"52","author":"Bozdogan","year":"1987","journal-title":"Psychometrika"},{"key":"B51","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"B52","first-page":"137","article-title":"GWA analysis in presence of stratification: theory","volume-title":"GenABEL Tutorial","author":"Aulchenko","year":"2015"},{"key":"B53","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common disease and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1136\/bmj.296.6632.1313","article-title":"Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates","volume":"296","author":"Morris","year":"1988","journal-title":"Brit Med J"},{"key":"B55","first-page":"229","article-title":"Comparing groups \u2013 categorical data. In: Altman DG, editor","volume-title":"Practical Statistics for Medical Research","author":"Altman","year":"1991"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.2527\/jas.2016.1152","article-title":"Identification of loci associated with susceptibility to Mycobacterium avium subspecies paratuberculosis (MAP) tissue infection in cattle","volume":"95","author":"Kiser","year":"2017","journal-title":"J Anim Sci"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e61756","DOI":"10.1371\/journal.pone.0061756","article-title":"Whole genome association studies of residual feed intake and related traits in the pig","volume":"8","author":"Onteru","year":"2013","journal-title":"PLoS ONE"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e0173482","DOI":"10.1371\/journal.pone.0173482","article-title":"Genome-wide association analysis and functional annotation of positional candidate genes for feed conversion efficiency and growth rate in pigs","volume":"12","author":"Horodyska","year":"2017","journal-title":"PLoS ONE"},{"key":"B59","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3389\/fgene.2019.00302","article-title":"Genome-wide association study reveals candidate genes for growth relevant traits in pigs","volume":"10","author":"Tang","year":"2019","journal-title":"Front Genet"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.2527\/jas.2012-6052","article-title":"Linkage disequilibrium and haplotype block structure in six commercial pig lines","volume":"91","author":"Veroneze","year":"2013","journal-title":"J Anim Sci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/nar\/27.1.29","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"27","author":"Ogata","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"B62","doi-asserted-by":"crossref","first-page":"23736","DOI":"10.1016\/S0021-9258(17)31577-6","article-title":"Saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acylosyacyl hydrolase","volume":"269","author":"Staab","year":"1994","journal-title":"J Biol Chem"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1128\/IAI.72.6.3171-3178.2004","article-title":"Identification of acycloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract","volume":"72","author":"Feulner","year":"2004","journal-title":"Infect Immun"},{"key":"B64","doi-asserted-by":"publisher","first-page":"E896","DOI":"10.1073\/pnas.1719834115","article-title":"Crystal structure of the mammalian lipopolysacharide detoxifier","volume":"115","author":"Gorelik","year":"2018","journal-title":"Proc Nat Acad Sci USA"},{"key":"B65","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.chom.2008.06.009","article-title":"Host inactivation of bacterial lipopolysaccharide prevents prolonged microbial tolerance following Gram-negative bacterial infection","volume":"4","author":"Lu","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B66","doi-asserted-by":"publisher","first-page":"8415","DOI":"10.1021\/bi00098a020","article-title":"Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides","volume":"30","author":"Hagen","year":"1991","journal-title":"Biochem"},{"key":"B67","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/ni1246","article-title":"Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria","volume":"6","author":"Lu","year":"2005","journal-title":"Nat Immunol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e1006436","DOI":"10.1371\/journal.ppat.1006436","article-title":"Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury","volume":"13","author":"Zou","year":"2017","journal-title":"PLoS Pathogen"},{"key":"B69","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.4049\/jimmunol.141.5.1445","article-title":"Intracellular interference with antigen presentation","volume":"141","author":"Leyva-Cobian","year":"1988","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.1128\/IAI.67.8.4048-4054.1999","article-title":"Interaction of Brucella abortus Lipopolysaccharide with major histocompatibility complex class II molecules in B lymphocytes","volume":"67","author":"Forestier","year":"1999","journal-title":"Infect Immun"},{"key":"B71","doi-asserted-by":"publisher","first-page":"6062","DOI":"10.4049\/jimmunol.1303348","article-title":"Essential role of Elmo1 in Dock2-dependent lymphocyte migration","volume":"192","author":"Stevenson","year":"2014","journal-title":"J Immun"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1093\/infdis\/jix528","article-title":"ELMO1 regulates autophagy induction and bacterial clearance during enteric infection","volume":"216","author":"Sarkar","year":"2017","journal-title":"J Infect Dis"},{"key":"B73","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jcmgh.2015.04.002","article-title":"ELMO1: more than just a director of phagocytosis","volume":"1","author":"McCormick","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1158\/0008-5472.CAN-12-2569","article-title":"CD103 or LFA-1 engagement at the immune synapse between cytotoxic T cells and tumor cells promotes maturation and regulates T-cell effector functions","volume":"73","author":"Franciszkiewicz","year":"2013","journal-title":"Cancer Res"},{"key":"B75","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: Structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"B76","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/sj.bjc.6601906","article-title":"Polymorphisms in prostaglandin synthase 2\/cyclooxygenase 2 (PTGS2\/COX2) and risk of colorectal cancer","volume":"91","author":"Cox","year":"2004","journal-title":"Brit J Cancer"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1172\/JCI6400","article-title":"Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development","volume":"103","author":"Rocca","year":"1999","journal-title":"J Clin Invest"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3389\/fmicb.2016.01987","article-title":"COX-2 inhibition reduces Brucella bacterial burden in draining lymph nodes","volume":"7","author":"Gagnaire","year":"2016","journal-title":"Front Microbiol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1006\/bbrc.2001.5995","article-title":"Brucella lipopolysaccharides induce cyclooxygenase-2 expression in monocytic cells","volume":"289","author":"L\u00f3pez-Urrutia","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"B80","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S1471-4906(01)02154-8","article-title":"Prostaglandins as modulators of immunity","volume":"23","author":"Harris","year":"2002","journal-title":"Trends Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.4049\/jimmunol.178.4.2065","article-title":"Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response","volume":"178","author":"Woolard","year":"2007","journal-title":"J Immunol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.tvjl.2006.01.010","article-title":"Engagement of integrins as a celular route of invasion by bacterial pathogens","volume":"173","author":"Scibelli","year":"2007","journal-title":"Vet J"},{"key":"B83","first-page":"143","article-title":"The biological functions of \u03b23 integrins","volume":"50","author":"Switala-Jelen","year":"2004","journal-title":"Folia Biol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10549-005-9089-4","article-title":"Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk","volume":"97","author":"Langsenlehner","year":"2006","journal-title":"Breast Cancer Res Treat"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.jaci.2007.03.029","article-title":"Integrin \u03b23 genotype influences asthma and allergy phenotypes in the first 6 years of life","volume":"119","author":"Thompson","year":"2007","journal-title":"J Allergy Clin Immuno"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e01384","DOI":"10.1128\/JVI.01384-19","article-title":"Kaposi's sarcoma-associated herpesvirus viral interleukin-6 signaling upregulates integrin \u03b23 levels and is dependent on STAT3","volume":"94","author":"Rivera-Soto","year":"2020","journal-title":"J Virol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1095\/biolreprod.112.100883","article-title":"Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits adhesion of human endometriotic epithelial and stromal cells through suppression of integrin-mediated mechanisms","volume":"88","author":"Lee","year":"2013","journal-title":"Biol Reprod"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1016\/j.celrep.2017.02.012","article-title":"Integrin beta 3 regulates cellular senescence by activating the TGF-\u03b2 pathway","volume":"18","author":"Rapisarda","year":"2017","journal-title":"Cell Rep"},{"key":"B89","doi-asserted-by":"publisher","first-page":"4656","DOI":"10.1038\/s41598-017-04844-w","article-title":"The importance of N-glycosylation on \u03b2 3 integrin ligand binding and conformational regulation","volume":"7","author":"Cai","year":"2017","journal-title":"Sci Rep"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1095\/biolreprod.105.041889","article-title":"Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the C-type lysozyme\/alpha-lactalbumin family","volume":"73","author":"Zhang","year":"2005","journal-title":"Biol Repro"},{"key":"B91","doi-asserted-by":"publisher","first-page":"e1006512","DOI":"10.1371\/journal.ppat.1006512","article-title":"From bacterial killing to immune modulation: Recent insights into the functions of lysozyme","volume":"13","author":"Ragland","year":"2017","journal-title":"PLoS Pathog"},{"key":"B92","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S1286-4579(00)90368-X","article-title":"Invasion and intracellular trafficking of Brucella abortus in nonphagocytic cells","volume":"2","author":"Pizarro-Cerd\u00e1","year":"2000","journal-title":"Microbes Infect"},{"key":"B93","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1128\/microbiolspec.BAI-0022-2019","article-title":"Manipulation of host cell organelles by intracellular pathogens","volume-title":"Bacteria and Intracellularity","author":"Omotade","year":"2019"},{"key":"B94","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1128\/9781555819286.ch23","article-title":"Contrasting lifestyles within the host cell","volume-title":"Virulence Mechanisms of Bacterial Pathogens","author":"Case","year":"2016"},{"key":"B95","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-\u03baB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"B96","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-kB in immunology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res"},{"key":"B97","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-\u03baB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"10211","DOI":"10.1128\/JVI.00323-12","article-title":"The NS1 protein of influenza a virus blocks RIG-I-mediated activation of the noncanonical NF-B pathway and p52\/RelB-dependent gene expression in lung epithelial cells","volume":"86","author":"Rckle","year":"2012","journal-title":"J Virol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.immuni.2014.02.006","article-title":"Noncanonical NF-\u03baB pathway controls the production of type I interferons in antiviral innate immunity","volume":"40","author":"Jin","year":"2014","journal-title":"Immunity"},{"key":"B101","doi-asserted-by":"publisher","first-page":"23169","DOI":"10.1074\/jbc.M802729200","article-title":"Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-\u03baB2 complexes via a novel retinoic acid-inducible gene-I\u00b7 NF-\u03baB-inducing kinase signaling pathway","volume":"283","author":"Liu","year":"2008","journal-title":"J Biol Chem"},{"key":"B102","doi-asserted-by":"publisher","first-page":"9399","DOI":"10.1073\/pnas.0308016101","article-title":"Activation of alternative NF-\u03baB pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1\u03b2-converting enzyme inhibitory protein (vFLIP)","volume":"101","author":"Matta","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B103","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.virol.2006.09.001","article-title":"Activation of non-canonical NF-kB pthway mediated by STP-A11, an oncoprotein of Herpesvirus saimiri","volume":"359","author":"Cho","year":"2007","journal-title":"Virology"},{"key":"B104","doi-asserted-by":"publisher","first-page":"ra27","DOI":"10.1126\/scisignal.2003309","article-title":"Noncanonical NF-\u03baB activation by the oncoprotein Tio occurs through a nonconserved TRAF3-binding motif","volume":"6","author":"de Jong","year":"2013","journal-title":"Sci Signal"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1111\/j.1440-1746.2007.04831.x","article-title":"Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates","volume":"22","author":"Yanai","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"13725","DOI":"10.1073\/pnas.0907200106","article-title":"A Legionella type IV effector activates the NF-\u03baB pathway by phosphorylating the I\u03baB family of inhibitors","volume":"106","author":"Ge","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B107","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3389\/fcimb.2017.00437","article-title":"Activation of NF-kB-mediated TNF-induced antimicrobial immunity is required for the efficient Brucella abortus clearance in RAW 264.7 cells","volume":"7","author":"Hop","year":"2017","journal-title":"Front Cell Infect Microbiol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12866-018-1185-9","article-title":"Heat-stress-modulated induction of NF-\u03baB leads to brucellacidal pro-inflammatory defense against Brucella abortus infection in murine macrophages and in a mouse model","volume":"18","author":"Hop","year":"2018","journal-title":"BMC Microbiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.biocel.2012.01.020","article-title":"Tetraspanins: interactions and interplay with integrins","volume":"44","author":"Bassani","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00223-014-9883-2","article-title":"Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro","volume":"95","author":"Zhou","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"B111","doi-asserted-by":"publisher","first-page":"9551","DOI":"10.1074\/jbc.M116.765669","article-title":"New insights into the tetraspanin Tspan5 using novel monoclonal antibodies","volume":"292","author":"Saint-Pol","year":"2017","journal-title":"J Bio Chem"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.3389\/fimmu.2018.01277","article-title":"Immune targeting of tetraspanins involved in cell invasion and metastasis","volume":"9","author":"Vences-Catal\u00e1n","year":"2018","journal-title":"Front Immunol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3389\/fcell.2017.00034","article-title":"Tetraspanins function as regulators of cellular signaling","volume":"5","author":"Termini","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.bbagen.2019.01.015","article-title":"Generation of the heterogeneity of extracellular vesicles by membrane organization and sorting machineries","volume":"1863","author":"Harada","year":"2019","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"B115","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0014-5793(94)01134-6","article-title":"Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon","volume":"354","author":"Di Cesare","year":"1994","journal-title":"FEBS Lett"},{"key":"B116","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/cne.20439","article-title":"Tetraspanin-5 (Tm4sf9) mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En-2 transgenic mice","volume":"483","author":"Juenger","year":"2005","journal-title":"J Comp Neurol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.matbio.2014.06.001","article-title":"Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: interaction, regulation and role in condrogenesis","volume":"37","author":"Acharya","year":"2014","journal-title":"Matrix Biol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2174\/1570161115666170201121232","article-title":"Cartilage oligomeric matrix proteins: matricellular and matricrine signaling in cardiovascular homeostasis and disease","volume":"15","author":"Fu","year":"2017","journal-title":"Curr Vasc Pharmacol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.2174\/138161209788682442","article-title":"ADAM10 as a therapeutic target for cancer and inflammation","volume":"15","author":"Crawford","year":"2009","journal-title":"Curr Pharm Des"},{"key":"B120","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/all.13261","article-title":"ADAM 10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production","volume":"73","author":"Damle","year":"2018","journal-title":"Allergy"},{"key":"B121","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41577-018-0068-5","article-title":"The emerging role of ADAM metalloproteinases in immunity","volume":"18","author":"Lambrecht","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/0092-8674(95)90171-X","article-title":"Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease","volume":"83","author":"Hibbs","year":"1995","journal-title":"Cell"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1084\/jem.20020515","article-title":"Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity","volume":"196","author":"Hibbs","year":"2002","journal-title":"J Exp Med"},{"key":"B124","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S1074-7613(04)00381-4","article-title":"Lyn tyrosine kinase: accentuating the positive and the negative","volume":"22","author":"Xu","year":"2005","journal-title":"Immunity"},{"key":"B125","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1600-065X.2008.00758.x","article-title":"Multiple roles of Lyn kinase in myeloid cell signaling and function","volume":"228","author":"Scapini","year":"2009","journal-title":"Immunol Rev."},{"key":"B126","doi-asserted-by":"publisher","first-page":"7887","DOI":"10.1074\/jbc.275.11.7887","article-title":"HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells","volume":"275","author":"Ingley","year":"2000","journal-title":"J Biol Chem"},{"key":"B127","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1182\/blood.V91.10.3734","article-title":"Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway","volume":"91","author":"Chin","year":"1998","journal-title":"Blood"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1093\/emboj\/16.7.1610","article-title":"Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells","volume":"16","author":"Tilbrook","year":"1997","journal-title":"EMBO J"},{"key":"B129","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S1074-7613(01)00208-4","article-title":"Gain-and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage","volume":"15","author":"Harder","year":"2001","journal-title":"Immunity"},{"key":"B130","doi-asserted-by":"publisher","first-page":"8001","DOI":"10.1038\/sj.onc.1208075","article-title":"Src-family kinases in B-cell development and signaling","volume":"23","author":"Gauld","year":"2004","journal-title":"Oncogene"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1091\/mbc.E16-09-0632","article-title":"Association of Lyn kinase with membrane rafts determines its negative influence on LPS-induced signaling","volume":"28","author":"Borz\u0229cka-Solarz","year":"2017","journal-title":"Mol Biol Cell"},{"key":"B132","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.immuni.2016.07.015","article-title":"Lyn kinase suppresses the transcriptional activity of IRF5 in the TLR-MyD88 pathway to restrain the development of autoimmunity","volume":"45","author":"Ban","year":"2016","journal-title":"Immunity"},{"key":"B133","doi-asserted-by":"publisher","first-page":"5809","DOI":"10.4049\/jimmunol.0901423","article-title":"Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn\/PI3K module and promoted by SHIP1","volume":"184","author":"Keck","year":"2010","journal-title":"J Immun"},{"key":"B134","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1074\/jbc.M509333200","article-title":"Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain","volume":"281","author":"Veit","year":"2006","journal-title":"J Bio Chem"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s00439-012-1174-2","article-title":"Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients","volume":"131","author":"Kennedy","year":"2012","journal-title":"Hum Genet"},{"key":"B136","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1186\/s12864-018-5050-x","article-title":"Prioritizing candidate genes post-GWAS using multiple sources of data for mastitis resistance in dairy cattle","volume":"19","author":"Cai","year":"2018","journal-title":"BMC Genomics"},{"key":"B137","doi-asserted-by":"publisher","first-page":"605","DOI":"10.4103\/aja.aja_21_19","article-title":"Comprehensive transcriptome analysis based on RNA sequencing identifies critical genes for lipopolysaccharide-induced epididymitis in a rat model","volume":"21","author":"Song","year":"2019","journal-title":"Asian J Androl"},{"key":"B138","doi-asserted-by":"publisher","first-page":"819","DOI":"10.15252\/msb.20156123","article-title":"Time-and compartment-resolved proteome profiling of the extracellular niche in lung injury and repair","volume":"11","author":"Schiller","year":"2015","journal-title":"Mol Syst Biol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.cytogfr.2011.10.001","article-title":"Understanding the mechanism of IL-1\u03b2 secretion","volume":"22","author":"Lopez-Castejon","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"B140","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.molimm.2017.01.014","article-title":"Inflammasomes in the lung","volume":"86","author":"Pinkerton","year":"2017","journal-title":"Mol Immunol"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3389\/fimmu.2017.01011","article-title":"Btp proteins from Brucella abortus modulate the lung innate immune response to infection by the respiratory route","volume":"8","author":"Hielpos","year":"2017","journal-title":"Front Immunol"},{"key":"B142","doi-asserted-by":"crossref","first-page":"829","DOI":"10.4049\/jimmunol.161.2.829","article-title":"Mapping quantitative trait loci for immune capacity in the pig","volume":"161","author":"Edfors-Lilja","year":"1998","journal-title":"J Immunol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.5713\/ajas.2012.12503","article-title":"A whole genome association study to detect single nucleotide polymorphisms for blood components (immunity) in a cross between Korean native pig and Yorkshire","volume":"25","author":"Lee","year":"2012","journal-title":"Asian-Australas J Anim Sci"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1016\/j.bbadis.2014.03.011","article-title":"Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease","volume":"1842","author":"Hrdlickova","year":"2014","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B145","doi-asserted-by":"publisher","first-page":"R102","DOI":"10.1093\/hmg\/ddv259","article-title":"Non-coding genetic variants in human disease","volume":"24","author":"Zhang","year":"2014","journal-title":"Hum Mol Genet"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1093\/bib\/bby039","article-title":"Regulatory variants: from detection to predicting impact","volume":"20","author":"Rojano","year":"2018","journal-title":"Brief Bioinform"},{"key":"B147","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.3389\/fimmu.2018.02046","article-title":"Variation in the untranslated genome and susceptibility to infections","volume":"9","author":"Ramsuran","year":"2018","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-019-0486-6","article-title":"Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia","volume":"9","author":"Trossbach","year":"2019","journal-title":"Transl Psychiatry"},{"key":"B149","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1128\/CMR.16.3.463-496.2003","article-title":"Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence","volume":"16","author":"Smith","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"B150","doi-asserted-by":"publisher","first-page":"200","DOI":"10.20506\/rst.17.1.1085","article-title":"Genetic resistance to bacterial diseases of animals","volume":"17","author":"Adams","year":"1998","journal-title":"Rev Sci Tech"},{"key":"B151","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1128\/IAI.69.5.3110-3119.2001","article-title":"Stable transfection of bovine Nramp1 gene into murine RAW264.7 cells: effect on Brucella abortus survival","volume":"69","author":"Barthel","year":"2001","journal-title":"Infect Immun"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1007\/s11033-014-3136-3","article-title":"Polymorphism of cytokine and innate immunity genes associated with bovine brucellosis in cattle","volume":"41","author":"Prakash","year":"2014","journal-title":"Mol Biol Rep"},{"key":"B153","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.vetmic.2017.06.001","article-title":"A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats","volume":"207","author":"Rossi","year":"2017","journal-title":"Vet Microbiol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.cyto.2018.11.024","article-title":"Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: A candidate gene based analysis of InDel polymorphisms in goats","volume":"115","author":"Rossi","year":"2019","journal-title":"Cytokine"},{"key":"B155","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1111\/j.1365-2370.2003.00419.x","article-title":"Polymorphisms of the interferon gamma and interleukin 10 genes in human brucellosis","volume":"3","author":"Bravo","year":"2003","journal-title":"Eur J Immunogenet"},{"key":"B156","volume-title":"Emerging and Exotic Diseases of Animals.","author":"Spickler","year":"2010"},{"key":"B157","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1093\/bfgp\/elr026","article-title":"Brucella genomics as we enter the multi-genome era","volume":"10","author":"O'Callaghan","year":"2011","journal-title":"Brief Funct Genomics"},{"key":"B158","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.bbadis.2014.04.025","article-title":"Systems genetics: From GWAS to disease pathways","volume":"1842","author":"van der Sijde","year":"2014","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B159","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.ajhg.2018.04.002","article-title":"The post-GWAS era: from association to function","volume":"102","author":"Gallagher","year":"2018","journal-title":"Am J Hum Genet"},{"key":"B160","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/ele.12732","article-title":"Inferring infection hazard in wildlife populations by linking data across individual and population scales","volume":"20","author":"Pepin","year":"2017","journal-title":"Ecol Lett"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetmic.2013.02.025","article-title":"Feral swine brucellosis in the United States and prospective genomic techniques for disease epidemiology","volume":"166","author":"Leiser","year":"2013","journal-title":"Vet Microbio"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2020.554674\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:52:10Z","timestamp":1723942330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2020.554674\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":161,"alternative-id":["10.3389\/fvets.2020.554674"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2020.554674","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"article-number":"554674"}}