{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:59:07Z","timestamp":1785236347984,"version":"3.55.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"DOI":"10.3389\/fvets.2020.588919","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T04:37:37Z","timestamp":1605760657000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Transferable Resistance to Highest Priority Critically Important Antibiotics for Human Health in Escherichia coli Strains Obtained From Livestock Feces in Uruguay"],"prefix":"10.3389","volume":"7","author":[{"given":"Nadia","family":"Coppola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibiana","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Umpi\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s F.","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"\u00c1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Trenchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Laura","family":"Casaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Zunino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Bado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Vignoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3201\/eid0903.020208","article-title":"Emerging human infectious diseases: anthroponoses, zoonoses, and sapronoses","volume":"9","author":"Hubalek","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"20140085","DOI":"10.1098\/rstb.2014.0085","article-title":"The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward","volume":"370","author":"Aarestrup","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev.publhealth.24.100901.140853","article-title":"Health issues of air travel","volume":"24","author":"DeHart","year":"2003","journal-title":"Annu Rev Public Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1S","DOI":"10.1046\/j.1365-2672.94.s1.1.x","article-title":"The traveller and emerging infections: sentinel, courier, transmitter","volume":"94","author":"Wilson","year":"2003","journal-title":"J Appl Microbiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1093\/jac\/dkq004","article-title":"Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum-beta-lacta-mase-producing Escherichia coli among companion animals","volume":"65","author":"Ewers","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"B6","unstructured":"Plan de Acci\u00f3n Mundial sobre la Resistencia a los Antimicrobianos2016"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals","volume":"112","author":"Van Boeckel","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/microorganisms5010011","article-title":"The food production environment and the development of antimicrobial resistance in human pathogens of animal origin","volume":"5","author":"Lekshmi","year":"2017","journal-title":"Microorganisms"},{"key":"B9","volume-title":"WHO Guidelines on Use of Medically Important Antimicrobials in Food-Producing Animals: Web Annex A: Evidence Base","year":"2017"},{"key":"B10","volume-title":"Critically Important Antimicrobials for Human Medicine","year":"2017"},{"key":"B11","first-page":"383","article-title":"Antimicrobial resistance. Global report on surveillance","volume":"61","year":"2014","journal-title":"Bull WHO."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1086\/605630","article-title":"Hospital and societal costs of antimicrobial-resistant infections in a Chicago Teaching Hospital: implications for antibiotic stewardship","volume":"49","author":"Roberts","year":"2009","journal-title":"Clin Infect Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1155\/2015\/274298","article-title":"Value of anaggregate index in describing the impact of trends in antimicrobial resistance for Escherichia coli","volume":"26","author":"Patrick","year":"2015","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1264\/jsme2.ME17046","article-title":"Zoonotic potential and antibiotic resistance of Escherichia coli in neonatal calves in Uruguay","volume":"32","author":"Umpi\u00e9rrez","year":"2017","journal-title":"Microbes Environ."},{"key":"B15","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: 30th Informational Supplement. M100-S30","year":"2020"},{"key":"B16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.jgar.2016.06.002","article-title":"Analysis of plasmid mediated quinolone and oxyimino-cephalosporin resistance mechanisms in Uruguayan Salmonella enterica isolates from 2011 to 2013","volume":"6","author":"Cordeiro","year":"2016","journal-title":"J Glob Antimicrob Resist."},{"key":"B17","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ram.2019.10.003","article-title":"First characterization of K. pneumoniae ST11 clinical isolates harboring blaKPC-3 in Latin America","volume":"52","author":"Garcia-Fulgueiras","year":"","journal-title":"Rev Argent Microbiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.3389\/fmicb.2017.02078","article-title":"A multiplex SYBR green real-time PCR assay for the detection of three colistin resistance genes from cultured bacteria, feces, and environment samples","volume":"8","author":"Li","year":"2017","journal-title":"Front Microbiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"30589","DOI":"10.2807\/1560-7917.ES.2017.22.31.30589","article-title":"Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016","volume":"22","author":"Carattoli","year":"2017","journal-title":"Eurosurveillance"},{"key":"B20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13104-019-4144-0","article-title":"Colistin-resistant Escherichia coli with mcr genes in the livestock of rural small-scale farms in Ecuador","volume":"12","author":"Yamamoto","year":"2019","journal-title":"BMC Res Notes"},{"key":"B21","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jgar.2019.03.011","article-title":"Multidrug-resistant Escherichia coli harbouring mcr-1 and blaCTX-M genes isolated from swine in Argentina","volume":"18","author":"Faccone","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"B22","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ijantimicag.2018.03.022","article-title":"Co-occurrence of mcr-1, mcr-4 and mcr-5 genes in multidrug-resistant ST10 enterotoxigenic and Shiga toxin-producing Escherichia coli in Spain (2006-2017)","volume":"52","author":"Garc\u00eda","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"B23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jgar.2019.07.016","article-title":"First three Escherichia coli isolates harbouring mcr-1 in Uruguay","volume":"20","author":"Papa-Ezdra","year":"2020","journal-title":"J Glob Antimicrob Resist."},{"key":"B24","doi-asserted-by":"publisher","first-page":"567","DOI":"10.3390\/antibiotics4040567","article-title":"Co-selection of resistance to antibiotics, biocides and heavy metals, and its relevance to foodborne pathogens","volume":"4","author":"Wales","year":"2015","journal-title":"Antibiotics."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3389\/fmicb.2018.01217","article-title":"Molecular epidemiology of mcr-encoded colistin resistance in enterobacteriaceae from food-producing animals in Italy revealed through the EU harmonized antimicrobial resistance monitoring","volume":"9","author":"Alba","year":"2018","journal-title":"Front Microbiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S1473-3099(16)00007-4","article-title":"Co-occurrence of extended spectrum? lactamase and MCR-1 encoding genes on plasmids","volume":"16","author":"Haenni","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"B27","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S1473-3099(16)00067-0","article-title":"Dissemination of the mcr-1 colistin resistance gene","volume":"16","author":"Mulvey","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1086\/533474","article-title":"Duration of stool colonization in patients infected with extended- spectrum \u03b2-lactamase\u2013producing Escherichia coli and Klebsiella pneumoniae. Reply to Rogers and Curry","volume":"46","author":"Treisman","year":"2008","journal-title":"Clin Infect Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1590\/S1413-86702001000100002","article-title":"Multicenter evaluation of resistance patterns of Klebsiella pneumoniae, Escherichia coli, Salmonella spp and Shigella spp isolated from clinical specimens in Brazil: RESISTNET surveillance program","volume":"5","author":"Oplustil","year":"2001","journal-title":"Brazil J Infect Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e02474","DOI":"10.1128\/AAC.02474-16","article-title":"Coexistence of CTX-M-2, CTX-M-55, CMY-2, FosA3, and QnrB19 in extraintestinal pathogenic Escherichia coli from poultry in Brazil","volume":"61","author":"Cunha","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"B31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jgar.2018.01.015","article-title":"Draft genome sequence of a CTX-M-8, CTX-M-55 and FosA3 co-producing Escherichia coli ST117\/B2 isolated from an asymptomatic carrier","volume":"12","author":"Fernandes","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"key":"B32","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jgar.2017.01.008","article-title":"Allodemic distribution of plasmids co harbouring CTX-M-15\/Aac(6')Ib-cr\/QnrB in K. pneumoniae is the main source of ESBL in Uruguay's Paediatric Hospital","volume":"9","author":"Garcia-Fulgueiras","year":"2017","journal-title":"J Glob Antimicrob Resist."},{"key":"B33","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3855\/jidc.6918","article-title":"Extended-spectrum \u03b2-lactamases, transferable quinolone-resistance and Virulotyping in extraintestinal E. coli in Uruguay","volume":"10","author":"Vignoli","year":"2016","journal-title":"J infect Dev Ctries."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jgar.2016.02.001","article-title":"CTX-M-15 in combination with aac(6\u2032)-Ib-cr is the most prevalent mechanism of resistance both in Escherichia coli and Klebsiella pneumoniae, including K. pneumoniae ST258, in an ICU in Uruguay","volume":"6","author":"Bado","year":"2016","journal-title":"J Glob Antimicrob Resist"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e00571","DOI":"10.1128\/AAC.00571-19","article-title":"Early dissemination of qnrE1 in Salmonella enterica Serovar Typhimurium from livestock in South America","volume":"63","author":"Monte","year":"2019","journal-title":"Antimicrob Agents Chemother."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e02555","DOI":"10.1128\/AAC.02555-16","article-title":"qnrE1, a member of a new family of plasmid-located quinolone resistance genes originated from the chromosome of Enterobacter spp","volume":"61","author":"Albornoz","year":"2017","journal-title":"Antimicrob Agent Chemother."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1093\/jac\/dkr222","article-title":"Extended-spectrum \u03b2-lactamases and plasmid-mediated quinolone resistance in enterobacterial clinical isolates in the paediatric hospital of Uruguay","volume":"66","author":"Garcia-Fulgueiras","year":"2011","journal-title":"J Antimicrob Chemother"}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2020.588919\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T04:37:49Z","timestamp":1605760669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2020.588919\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":37,"alternative-id":["10.3389\/fvets.2020.588919"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2020.588919","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"article-number":"588919"}}