{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:28:24Z","timestamp":1792114104719,"version":"4.4.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>This study aimed to determine the efficacy of dietary algae-derived polysaccharides (ADPs) from <jats:italic>Enteromorpha<\/jats:italic> on growth performance, intestinal morphology, intestinal permeability, and antioxidant capacity in serum, liver, and intestinal mucosa of broilers. Three hundred and ninety six day-old male chicks were randomly assigned to six dietary treatments containing 0 (Control), 1,000, 2,500, 4,000, 5,500, and 7,000 mg ADP\/kg basal diet in a 35 day feeding trial. During day 1\u201321, compared with the control group, dietary 1,000\u20137,000 mg\/kg ADP supplementation improved the average daily gain (ADG) and feed conversion ratio (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Overall (day 1\u201335), dietary inclusion of 1,000 mg\/kg ADP increased the final body weight and ADG (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Besides, on day 21, dietary 2,500 mg\/kg ADP supplementation increased the serum catalase (CAT) and liver total superoxide dismutase (T-SOD) activities (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), whereas dietary 1,000\u20135,500 mg\/kg ADP supplementation decreased malondialdehyde (MDA) contents in serum and liver (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). On day 35, supplementation of 1,000 mg\/kg ADP increased the serum glutathione peroxidase and CAT activities and liver T-SOD activities (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). It decreased the MDA level of serum and liver (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Also, dietary 2,500 mg\/kg ADP increased the villus height of jejunum and ileum on day 21 (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), and dietary 4,000 mg\/kg ADP increased the villus height of duodenum and ileum on day 35 (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). On day 21, dietary 4,000 mg\/kg ADP increased the CAT activities of the duodenum and T-SOD activities of jejunum and ileum and decreased the MDA contents in the duodenum, jejunum, and ileum (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). On day 35, dietary inclusion of 1,000\u20137,000 mg\/kg ADP reduced MDA contents of duodenum and jejunum (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). Furthermore, dietary inclusion of ADP at 1,000\u20137,000 mg\/kg decreased serum DAO activities at day 21 and day 35 (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), and the serum D-lactic acid concentration was reduced by dietary supplementation of 1,000, 2,500, and 7,000 mg\/kg ADP on day 21. In conclusion, dietary ADP exerted beneficial effects on growth performance, antioxidant capacity, and gut health in broilers; based on the studied parameters, the appropriate recommended dose is 1,000\u20134,000 mg\/kg. These findings provided new insights into the potential application of ADP as natural growth promoters in broilers.<\/jats:p>","DOI":"10.3389\/fvets.2020.601336","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T04:36:29Z","timestamp":1606883789000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":82,"title":["Algae-Derived Polysaccharides Promote Growth Performance by Improving Antioxidant Capacity and Intestinal Barrier Function in Broiler 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