{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:06:55Z","timestamp":1780056415802,"version":"3.54.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>The aim of this work was to test a surveillance protocol able to detect extended-spectrum \u03b2-lactamase (ESBL)-, cephalosporinase (AmpC)- and carbapenemase (CP)-producing gram-negative bacteria in three conveniently chosen dairy farms with known prior occurrences of ESBL- and CP-producing strains. The protocol was applied monthly for a year. At each visit, 10 healthy lactating dairy cows were rectally swabbed, and raw milk filters (RMFs) were sampled in two of the three farms. Bacterial isolation was based on a first screening step with MacConkey agar supplemented with 1 mg\/L cefotaxime and commercial carbapenem-supplemented media. We failed to detect CP-producing strains but showed that ESBL-<jats:italic>Escherichia<\/jats:italic> strains, found in one farm only (13 strains), were closely associated with multi-drug resistance (12 out of 13). The limited number of conveniently selected farms and the fact that RMFs could not be retrieved from one of them limit the validity of our findings. Still, our results illustrate that ESBL-status changes monthly based on fecal swabs and negative herds should be qualified as \u201cunsuspected\u201d as proposed by previous authors. Although surveillance of farm statuses based on RMF analysis could theoretically allow for a better sensitivity than individual swabs, we failed to illustrate it as both farms where RMFs could be retrieved were constantly negative. Determination of CP herd-level status based on RMFs and our surveillance protocol was hindered by the presence of intrinsically resistant bacteria or strains cumulating multiple non-CP resistance mechanisms which means our protocol is not specific enough for routine monitoring of CP in dairy farms.<\/jats:p>","DOI":"10.3389\/fvets.2021.633598","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T17:16:50Z","timestamp":1612977410000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Surveillance of Extended-Spectrum \u03b2-Lactamase-, Cephalosporinase- and Carbapenemase-Producing Gram-Negative Bacteria in Raw Milk Filters and Healthy Dairy Cattle in Three Farms in \u00cele-de-France, France"],"prefix":"10.3389","volume":"8","author":[{"given":"Vincent","family":"Plassard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Granier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Millemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.cmi.2017.01.013","article-title":"Extended-spectrum beta-lactamase\/AmpC- and carbapenemase-producing Enterobacteriaceae in animals: a threat for humans","volume":"23","author":"Madec","year":"2017","journal-title":"Clin Microbiol Infect."},{"key":"B2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.vetmic.2014.02.001","article-title":"An emerging public health problem: acquired carbapenemase-producing microorganisms are present in food-producing animals, their environment, companion animals and wild birds","volume":"171","author":"Guerra","year":"2014","journal-title":"Vet Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heliyon.2020.e03206","article-title":"Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production - a threat around the world","volume":"6","author":"Palmeira","year":"2020","journal-title":"Heliyon 6."},{"key":"B4","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/zph.12462","article-title":"Antimicrobial-resistant Enterobacteriaceae recovered from companion animal and livestock environments","volume":"65","author":"Adams","year":"2018","journal-title":"Zoonoses Public Health."},{"key":"B5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1089\/mdr.2016.0019","article-title":"High prevalence of Non-ST131 CTX-M-15-producing Escherichia coli in healthy cattle in Lebanon","volume":"23","author":"Diab","year":"2016","journal-title":"Microb Drug Resist."},{"key":"B6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fmicb.2012.00083","article-title":"Occurence of CTX-M producing Escherichia coli in soils, cattle, and farm environement in France (Burgundy region)","volume":"3","author":"Hartmann","year":"2012","journal-title":"Front Microbiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1128\/JCM.02299-07","article-title":"Prevalence of fecal carriage of acquired expanded-spectrum cephalosporin resistance in Enterobacteriaceae strains from Cattle in France","volume":"46","author":"Madec","year":"2008","journal-title":"J Clin Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3389\/fmicb.2016.01020","article-title":"Surveillance of extended-spectrum beta-lactamase-producing Escherichia coli in dairy cattle farms in the Nile delta, Egypt","volume":"7","author":"Braun","year":"2016","journal-title":"Front Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3201\/eid1803.111330","article-title":"Carbapenemase-producing Acinetobacter spp. in Cattle, France","volume":"18","author":"Poirel","year":"2012","journal-title":"Emerg Infect Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1128\/AEM.00204-13","article-title":"Prevalence of extended-spectrum beta-lactamase-producing Escherichia coli on Bavarian dairy and beef cattle farms","volume":"79","author":"Schmid","year":"2013","journal-title":"Appl Env Microb."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1111\/jam.14211","article-title":"Detection of extended-spectrum beta-lactam, AmpC and carbapenem resistance in Enterobacteriaceae in beef cattle in Great Britain in 2015","volume":"126","author":"Velasova","year":"2019","journal-title":"J Appl Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.vetmic.2019.04.005","article-title":"Prevalence of extended-spectrum and AmpC beta-lactamase-producing Escherichia coli in Dutch dairy herds","volume":"232","author":"Heuvelink","year":"2019","journal-title":"Vet Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.prevetmed.2017.05.003","article-title":"Cefotaxime-resistant E. coli in dairy and beef cattle farms - Joint analyses of two cross-sectional investigations in Germany","volume":"142","author":"Hille","year":"2017","journal-title":"Prev Vet Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"fiw013","DOI":"10.1093\/femsec\/fiw013","article-title":"Multidrug resistant, extended spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm","volume":"92","author":"Ibrahim","year":"2016","journal-title":"FEMS Microbiol Ecol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.vetmic.2011.07.020","article-title":"Epidemiology of extended spectrum beta-lactamase E. coli (CTX-M-15) on a commercial dairy farm","volume":"154","author":"Watson","year":"2012","journal-title":"Vet Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0147363","DOI":"10.1371\/journal.pone.0147363","article-title":"Carbapenem-resistant bacteria recovered from faeces of dairy cattle in the high plains region of the USA","volume":"11","author":"Webb","year":"2016","journal-title":"PLoS ONE."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1099\/jmm.0.000620","article-title":"OXA-48 and CTX-M-15 extended-spectrum beta-lactamases in raw milk in Lebanon: epidemic spread of dominant Klebsiella pneumoniae clones","volume":"66","author":"Diab","year":"2017","journal-title":"J Med Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1093\/jac\/dkw160","article-title":"blaNDM-5-carrying IncX3 plasmid in Escherichia coli ST1284 isolated from raw milk collected in a dairy farm in Algeria","volume":"71","author":"Yaici","year":"2016","journal-title":"J Antimicrob Chemother."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.prevetmed.2015.12.020","article-title":"An assessment of evidence data gaps in the investigation of possible transmission routes of extended-spectre beta-lactamase producing Escherichia coli from livestock to humans in the UK","volume":"124","author":"Horrigan","year":"2016","journal-title":"Prev Vet Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1089\/fpd.2007.0009","article-title":"The use of bulk tank milk samples to monitor trends in antimicrobial resistance on dairy farms","volume":"4","author":"Berge","year":"2007","journal-title":"Foodborne Pathog Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ijfoodmicro.2016.08.036","article-title":"Extended-spectrum beta-lactamase producing Enterobacteriaceae in bulk tank milk from German dairy farms","volume":"238","author":"Odenthal","year":"2016","journal-title":"Int J Food Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1089\/fpd.2006.3.222","article-title":"Public health significance of antimicrobial-resistant gram-negative bacteria in raw bulk tank milk","volume":"3","author":"Straley","year":"2006","journal-title":"Foodborne Pathog Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.rvsc.2017.07.019","article-title":"A new integrated approach to analyse bulk tank milk and raw milk filters for the presence of the E. coli serogroups frequently associated with VTEC status","volume":"115","author":"Albonico","year":"2017","journal-title":"Res Vet Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.3168\/jds.2016-12084","article-title":"Prevalence, antimicrobial resistance, and molecular characterization of Campylobacter spp. in bulk tank milk and milk filters from US dairies","volume":"100","author":"Del Collo","year":"2017","journal-title":"J Dairy Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3168\/jds.2012-5965","article-title":"Prevalence and antimicrobial susceptibility of Acinetobacter from raw bulk tank milk in Korea","volume":"96","author":"Gurung","year":"2013","journal-title":"J Dairy Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3168\/jds.2017-13546","article-title":"Prevalence of Salmonella enterica, Listeria monocytogenes, and pathogenic Escherichia coli in bulk tank milk and milk filters from US dairy operations in the National Animal Health Monitoring System Dairy 2014 study","volume":"101","author":"Sonnier","year":"2018","journal-title":"J Dairy Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.4315\/0362-028X-71.10.1967","article-title":"Environmental sampling to predict fecal prevalence Salmonella in an intensively monitored dairy herd","volume":"71","author":"Van Kessel","year":"2008","journal-title":"J Food Prot."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.4315\/0362-028X.JFP-12-028","article-title":"Foodborne pathogens in in-line milk filters and associated on-farm risk factors in dairy farms authorized to produce and sell raw milk in northern Italy","volume":"75","author":"Giacometti","year":"2012","journal-title":"J Food Prot."},{"key":"B29","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1128\/AEM.00465-15","article-title":"Dynamics of Escherichia coli virulence factors in dairy herds and farm environments in a longitudinal study in the United States","volume":"81","author":"Lambertini","year":"2015","journal-title":"Appl Env Microb."},{"key":"B30","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ijheh.2005.03.001","article-title":"In-line milk filter analysis: Escherichia coli O157 surveillance of milk production holdings","volume":"208","author":"Murphy","year":"2005","journal-title":"Int J Hyg Env Health."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.3168\/jds.2012-6249","article-title":"Presence of Campylobacter and Arcobacter species in in-line milk filters of farms authorized to produce and sell raw milk and of water buffalo dairy farm in Italy","volume":"96","author":"Serraino","year":"2013","journal-title":"J Dairy Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.vetmic.2010.11.032","article-title":"Short communication: IncN plasmids carrying blaCTX-M-1 in Escherichia coli isolates on a dairy farm","volume":"149","author":"Dolejska","year":"2011","journal-title":"Vet Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1089\/fpd.2018.2531","article-title":"Fecal carriage and whole-genome sequencing-assisted characterization of CMY-2 beta-lactamase producing Escherichia coli in calves at Czech dairy cow farm","volume":"16","author":"Manga","year":"2019","journal-title":"Foodborne Pathog Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.rvsc.2018.12.011","article-title":"Evaluation of virulence factors profiles and antimicrobials resistance of Escherichia coli isolated from bulk tank milk and raw milk filters","volume":"123","author":"Dell'Orco","year":"2019","journal-title":"Res Vet Sci."},{"key":"B35","volume-title":"Gram-negative bacteria resistant to critically important antimicrobials found in dairy cattle in Ile-de-France.","author":"Freilich","year":"2016"},{"key":"B36","unstructured":"Intrinsic Resistance and Unusual Phenotypes Version 3.22020"},{"key":"B37","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ijantimicag.2003.09.026","article-title":"Susceptibility of the Acinetobacter calcoaceticus-A. baumannii complex to imipenem, meropenem, sulbactam and colistin","volume":"23","author":"Diez","year":"2004","journal-title":"Int J Antimicrob Agents."},{"key":"B38","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1128\/AAC.37.4.750","article-title":"Antimicrobial susceptibility of Acinetobacter species","volume":"37","author":"Seifert","year":"1993","journal-title":"Antimicrob Agents Chemother."},{"key":"B39","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1128\/AAC.32.2.276","article-title":"In vitro susceptibility of Alcaligenes denitrificans subsp. xylosoxidans to 24 antimicrobial agents","volume":"32","author":"Glupczynski","year":"1988","journal-title":"Antimicob Agents Chemother."},{"key":"B40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.idcr.2016.02.009","article-title":"First report of Wautersiella falsenii genomovar 2 isolated from the respiratory tract of an immunosuppressed man","volume":"4","author":"Giordano","year":"2016","journal-title":"IDCases."},{"key":"B41","doi-asserted-by":"publisher","first-page":"7609602","DOI":"10.1155\/2016\/7609602","article-title":"Empedobacter brevis meningitis in a neonate: a very rare case of neonatal meningitis and literature review","volume":"2016","author":"Sharma","year":"2016","journal-title":"Case Rep Pediatr"},{"key":"B42","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0924-8579(03)00004-9","article-title":"In vitro susceptibility of Arcobacter butzleri and Arcobacter cryaerophilus to different antimicrobial agents","volume":"21","author":"Fera","year":"2003","journal-title":"Int J Antimicrob Ag."},{"key":"B43","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint Tables for Interpretation of MICs and Zone Diameters2020"},{"key":"B44","unstructured":"The European Committee on Antimicrobial Susceptibility TestingRoutine Extended Internal Quality Control for MIC Determination Disk Diffusion as Recommended by EUCAST2020"},{"key":"B45","unstructured":"Reading Guide: EUCAST Disk Diffusion Method for Antimicrobial Susceptibility Testing2020"},{"key":"B46","doi-asserted-by":"publisher","first-page":"6007","DOI":"10.2903\/j.efsa.2020.6007","article-title":"The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2017\/2018","volume":"18","year":"2020","journal-title":"EFSA J"},{"key":"B47","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2018"},{"key":"B48","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1590\/S1413-86702007000200014","article-title":"Utility of the ceftazidime-imipenem antagonism test (CIAT) to detect and confirm the presence of inducible AmpC beta-lactamases among Enterobacteriaceae","volume":"11","author":"Cantarelli","year":"2007","journal-title":"Braz J Infect Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1469-0691.2007.01846.x","article-title":"Phenotypic detection of extended-spectrum b-lactamase production in Enterobacteriaceae: review and bench guide","volume":"14","author":"Drieux","year":"2008","journal-title":"Clin Microbiol Infec."},{"key":"B50","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infec."},{"key":"B51","doi-asserted-by":"publisher","first-page":"9001","DOI":"10.3168\/jds.2016-11134","article-title":"Prevalence and risk factors for extended-spectrum beta-lactamase- and AmpC-producing Escherichia coli in dairy farms","volume":"99","author":"Gonggrijp","year":"2016","journal-title":"J Dairy Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"e00742","DOI":"10.1128\/AEM.00742-20","article-title":"Prevalence of cefotaxime-resistant Escherichia coli isolated from healthy cattle and sheep in northern Spain: phenotypic and genome-based characterization of antimicrobial susceptibility","volume":"86","author":"Tello","year":"2020","journal-title":"Appl Env Microb."},{"key":"B53","doi-asserted-by":"publisher","first-page":"391","DOI":"10.9775\/kvfd.2019.23329","article-title":"A molecular investigation of carbapenem resistant Enterobacteriaceae and blaKPC, blaNDM and blaOXA48 genes in raw milk","volume":"26","author":"Al","year":"2020","journal-title":"Kafkas Univ Vet Fak Derg."},{"key":"B54","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.diagmicrobio.2013.08.015","article-title":"Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae","volume":"77","author":"Girlich","year":"2013","journal-title":"Diagn Micro Infec Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10096-013-1925-6","article-title":"Performance of ChromID CARBA medium far carbapenemases-producing enterobacteriaceae detection during rectal screening","volume":"33","author":"Papadimitriou-Olivgeris","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1128\/JCM.06848-11","article-title":"Comparative evaluation of a prototype chromogenic medium (ChromID CARBA) for detecting carbapenemase-producing Enterobacteriaceae in surveillance rectal swabs","volume":"50","author":"Vrioni","year":"2012","journal-title":"J Clin Microbiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1198-743X.2004.00887.x","article-title":"European recommendations for antimicrobial resistance surveillance","volume":"10","author":"Cornaglia","year":"2004","journal-title":"Clin Microbiol Infect."},{"key":"B58","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.1128\/AAC.00574-09","article-title":"Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa","volume":"53","author":"Rodriguez-Martinez","year":"2009","journal-title":"Antimicob Agents Chemother"},{"key":"B59","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1128\/JCM.26.3.524-529.1988","article-title":"Virulence factors of lactose-negative Escherichia coli strains isolated from children with diarrhea in Somalia","volume":"1988","author":"Nicoletti","year":"1988","journal-title":"J Clin Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1136\/jcp.15.5.482","article-title":"An epidemic of gastroenteritis due to an uncommon variant of Escherichia coli 0.128","volume":"15","author":"Shedden","year":"1962","journal-title":"J Clin Pathol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"S589","DOI":"10.1093\/ofid\/ofx163.1546","article-title":"Lactose vs non-lactose fermenting E. coli: epidemiology, clinical outcomes, and resistance","volume":"4","author":"Yaratha","year":"2017","journal-title":"Open Forum Infect Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3168\/jds.2016-11839","article-title":"Prevalence and risk factors for extended-spectrum beta-lactamase or AmpC-producing Escherichia coli in organic dairy herds in the Netherlands","volume":"100","author":"Santman-Berends","year":"2017","journal-title":"J Dairy Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.vetmic.2006.01.006","article-title":"Short communication: molecular characterisation of bovine faecal Escherichia coli shows persistence of defined ampicillin resistant strains and the presence of class 1 integrons on an organic beef farm","volume":"115","author":"Hoyle","year":"2006","journal-title":"Vet Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.3168\/jds.2011-4785","article-title":"No seasonal effect on culturable pseudomonads in fresh milks from cattle herds","volume":"95","author":"Leriche","year":"2012","journal-title":"J Dairy Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"5652","DOI":"10.4081\/ijfs.2016.5652","article-title":"Dissemination and persistence of Pseudomonas spp. in small-scale dairy farms","volume":"5","author":"Nucera","year":"2016","journal-title":"Ital J Food Saf."},{"key":"B66","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1128\/CMR.00040-09","article-title":"Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms","volume":"22","author":"Lister","year":"2009","journal-title":"Clin Microbiol Rev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1128\/AAC.50.5.1633-1641.2006","article-title":"Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates","volume":"50","author":"Quale","year":"2006","journal-title":"Antimicrob Agents Chemother."},{"key":"B68","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.3168\/jds.2017-13277","article-title":"Salmonella enterica and extended-spectrum cephalosporin-resistant Escherichia coli recoverd from Holstein dairy calves from 8 farms in New Brunswick, Canada","volume":"101","author":"Awosile","year":"2018","journal-title":"J Dairy Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.rvsc.2016.09.018","article-title":"Longitudinal study of CTX-M ESBL-producing E. coli strains on a UK dairy farm","volume":"109","author":"Horton","year":"2016","journal-title":"Res Vet Sci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1128\/JCM.44.5.1630-1634.2006","article-title":"Longitudinal farm study of extended-spectrum-beta-lactamase-mediated resistance","volume":"44","author":"Liebana","year":"2006","journal-title":"J Clin Microbiol."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2021.633598\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T17:17:03Z","timestamp":1612977423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2021.633598\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":70,"alternative-id":["10.3389\/fvets.2021.633598"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2021.633598","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"article-number":"633598"}}