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It has been established that the Type IIb sodium-dependent phosphate cotransporters (NaPi-IIb) protein is the major sodium-dependent phosphate (Pi) transporter, which plays an important role in Pi uptake across the apical membrane of epithelial cells in the small intestine. Previous studies have demonstrated that epidermal growth factor (EGF) is involved in regulating intestinal Pi absorption. Here we summarize the effects of EGF on active Pi transport of NaPi-IIb under different conditions. Under normal conditions, EGF inhibits the active transport of Pi by inhibiting the expression of NaPi-IIb, while, under intestinal injury condition, EGF promotes the active absorption of Pi through upregulating the expression of NaPi-IIb. This review provides a reference for information about EGF-regulatory functions in Pi absorption in the animal intestine.<\/jats:p>","DOI":"10.3389\/fvets.2021.670140","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T07:12:41Z","timestamp":1623654761000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Mechanisms of Epidermal Growth Factor Effect on Animal Intestinal Phosphate Absorption: A Review"],"prefix":"10.3389","volume":"8","author":[{"given":"Xiaopeng","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.5713\/ajas.2012.12187","article-title":"Different phosphate transport in the duodenum and jejunum of chicken response to dietary phosphate adaptation","volume":"25","author":"Fang","year":"2012","journal-title":"Asian-Aust J Anim Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"35047","DOI":"10.1074\/jbc.M112.392415","article-title":"NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli","volume":"287","author":"Giral","year":"2012","journal-title":"J Biol Chem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00424-013-1418-6","article-title":"The SLC34 family of sodium-dependent phosphate transporters","volume":"466","author":"Wagner","year":"2014","journal-title":"Pflugers Arch."},{"key":"B4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s00418-018-1711-8","article-title":"Dietary phosphate toxicity: an emerging global health concern","volume":"150","author":"Erem","year":"2018","journal-title":"Histochem Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10557","DOI":"10.1007\/s11033-012-1941-0","article-title":"Molecular cloning and functional characterization of swine sodium dependent phosphate cotransporter type IIb (NaPi-IIb) gene","volume":"39","author":"Xiang","year":"2012","journal-title":"Mol Biol Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1681\/ASN.2011121213","article-title":"Npt2b deletion attenuates hyperphosphatemia associated with CKD","volume":"23","author":"Schiavi","year":"2012","journal-title":"J Am Soc Nephrol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1007\/s00467-012-2175-z","article-title":"Phosphate homeostasis and its role in bone health","volume":"27","author":"Penido","year":"2012","journal-title":"Pediatr Nephrol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2527\/jas.2015-9866","article-title":"Effects of mechanistic target of rapamycin signaling pathway on the estrogen-mediated NaPi-IIb protein expression in pig small intestinal epithelial cells","volume":"94","author":"Fang","year":"2016","journal-title":"J Anim Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"F39","DOI":"10.1152\/ajprenal.00375.2003","article-title":"Intestinal Na-Pi cotransporter adaptation to dietary Pi content in vitamin D receptor null mice","volume":"287","author":"Segawa","year":"","journal-title":"Am J Physiol Renal Physiol. 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