{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:25:15Z","timestamp":1790645115715,"version":"4.1.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p><jats:italic>Lactobacillus delbrueckii<\/jats:italic> is a Gram-positive bacterium mostly used in the dairy industry for yogurt and cheese. The present study was designed to evaluate the effects of <jats:italic>Lactobacillus delbrueckii<\/jats:italic> on serum biochemical parameters, intestinal morphology, and performance by supplementing at a dietary level of 0.1% in diets for weaned piglets. Eighty healthy weaned piglets (initial body weight: 7.56 \u00b1 0.2 kg) were randomly divided into two feeding groups with four replicates in each group (n = 10 animals per replicate); piglets were fed with basal diet (CON) or basal diet containing 0.1% <jats:italic>Lactobacillus delbrueckii<\/jats:italic> (LAC). The results showed that dietary supplementation of <jats:italic>Lactobacillus delbrueckii<\/jats:italic> improved growth performance and increased serum HDL and insulin levels in piglets on the 28th day of the experimental time (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The gut microbe analysis revealed that <jats:italic>Lactobacillus delbrueckii<\/jats:italic> significantly decreased the relative abundance of the phyla Bacteroidetes, but increased the relative abundance of the phyla Firmicutes. The <jats:italic>Lactobacillus delbrueckii<\/jats:italic> also significantly increased the relative abundance of <jats:italic>Bifidobacterium<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic> at the genus level of the bacterial community in the ileum, but decreased the relative abundance of unclassified <jats:italic>Clostridiales<\/jats:italic>. Moreover, <jats:italic>Lactobacillus delbrueckii<\/jats:italic> improved mucosal morphology by obtaining higher intestinal villus height (<jats:italic>p<\/jats:italic> &amp;lt; 0.05), significantly increasing the concentrations of butyrate, isobutyric acid, and isovaleric acid in colonic chyme of piglets, but decreasing the intestinal pH at the duodenum and ileum on the 28th day of the experimental time. In conclusion, dietary supplementation of <jats:italic>Lactobacillus delbrueckii<\/jats:italic> in the diet of weaned piglets can improve intestinal morphology and modulate the microbiota community to promote growth performance.<\/jats:p>","DOI":"10.3389\/fvets.2021.692389","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T12:08:54Z","timestamp":1629374934000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Dietary Supplementation of Lactobacillus delbrueckii on Gut Microbiome and Intestinal Morphology in Weaned 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