{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:09:59Z","timestamp":1791378599391,"version":"4.3.2"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A total of 480 one-day-old AA broiler chicks were randomly allocated to one of four treatments in a 2 \u00d7 2 factorial to investigate the effects of tannic acid (TA) on growth performance, relative organ weight, antioxidant capacity, and intestinal health in broilers dietary exposed to aflatoxin B<jats:sub>1<\/jats:sub> (AFB<jats:sub>1<\/jats:sub>). Treatments were as follows: (1) CON, control diet; (2) TA, CON + 250 mg\/kg TA; (3) AFB<jats:sub>1<\/jats:sub>, CON + 500 \u03bcg\/kg AFB<jats:sub>1<\/jats:sub>; and (4) TA+AFB<jats:sub>1<\/jats:sub>, CON + 250 mg\/kg TA + 500 \u03bcg\/kg AFB<jats:sub>1<\/jats:sub>. There were 10 replicate pens with 12 broilers per replicate. Dietary AFB<jats:sub>1<\/jats:sub> challenge increased the feed conversion ratio during days 1 to 21 (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The TA in the diet did not show significant effects on the growth performance of broilers during the whole experiment period (<jats:italic>P<\/jats:italic> &amp;gt; 0.05). The liver and kidney relative weight was increased in the AF challenge groups compared with the CON (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The addition of TA could alleviate the relative weight increase of liver and kidney caused by AFB<jats:sub>1<\/jats:sub> (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Broilers fed the AFB<jats:sub>1<\/jats:sub> diets had lower activity of glutathione peroxidase, catalase, total superoxide dismutase, S-transferase, and total antioxidant capacity in plasma, liver and jejunum, and greater malondialdehyde content (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Dietary supplemented with 250 mg\/kg TA increased the activities of antioxidative enzymes, and decreased malondialdehyde content (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). In addition, AFB<jats:sub>1<\/jats:sub> significantly reduced the villus height and crypt depth ratio in the ileum on day 42 (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). In conclusion, supplementation with 250 mg\/kg TA could partially protect the antioxidant capacity and prevent the enlargement of liver in broilers dietary challenged with 500 \u03bcg\/kg AFB<jats:sub>1<\/jats:sub>.<\/jats:p>","DOI":"10.3389\/fvets.2022.1037046","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T07:02:05Z","timestamp":1666335725000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin 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