{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:06:55Z","timestamp":1792476415021,"version":"4.5.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Antibiotics are widely used as growth promoters (AGPs) in livestock production to improve animal performance and health. However, pig producers today face the prohibition of in-feed antimicrobials and have to find safe and effective alternatives. <jats:italic>Lactobacillus<\/jats:italic> species are active microorganisms that convey multiple beneficial effects to the host and are one of the most promising AGPs replacements. Here, we aim to comprehensively assess the effects of <jats:italic>Lactobacillus<\/jats:italic> spp. supplementation on growth performance and intestinal morphology (villus height [VH], crypt depth [CD], and the V\/C ratio) of piglets. Among the 196 identified studies, 20 met the criteria and were included in the meta-analysis. The effects of <jats:italic>Lactobacillus<\/jats:italic>-based probiotics supplementation on growth performance and intestinal morphology were analyzed using a random-effects model. And the publication bias was evaluated by funnel plots. Our results revealed that <jats:italic>Lactobacillus<\/jats:italic> spp. supplementation significantly improved the growth performance, including average daily feed intake (ADFI), average daily gain (ADG), and the gain-to-feed ratio (G\/F) in piglets (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Meanwhile, <jats:italic>Lactobacillus<\/jats:italic> spp. remarkably increased VH and the V\/C ratio (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) in the small intestine, including the duodenum, jejunum, and ileum, which might contribute to an improved digestive capacity of these animals. In conclusion, our findings provide concrete evidence of the growth-promoting effects of <jats:italic>Lactobacillus<\/jats:italic> spp. supplementation in piglets and a better understanding of the potential of <jats:italic>Lactobacillus<\/jats:italic>-based probiotics as AGPs alternatives in pig production.<\/jats:p>","DOI":"10.3389\/fvets.2022.1045965","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T05:36:38Z","timestamp":1667885798000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in 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