{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:06:31Z","timestamp":1791875191413,"version":"4.3.4"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    The current study evaluated interactions between farrowing duration and litter size on the level of asphyxia, vitality, percentage of stillbirth, and pre-weaning mortality of piglets. Farrowing duration was measured in 159 crossbred gilts and sows (Yorkshire \u00d7 Dutch Landrace). Litter size ranged between 12 and 21 piglets. Blood acid\u2013base parameters in umbilical cord blood and vitality scores of piglets were determined immediately after birth. Number of piglets born alive and stillborn as well as individual piglet weights at birth were recorded. Pre-weaning mortality (excluding stillbirth) was determined throughout lactation. Litter size as well as farrowing duration were categorized to evaluate the interaction between the two. There tended to be an interaction between litter size and farrowing duration for pre-weaning mortality (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.10). In small litters (12\u201315 piglets), a prolonged farrowing duration (&amp;gt;250 min) tended to increase pre-weaning mortality compared with a short (&amp;lt;150 min) and medium farrowing duration (150\u2013250 min), while for large litters (19\u201321 piglets), a medium to long farrowing duration tended to decrease pre-weaning mortality. No other interactions between litter size and farrowing duration were found. Piglets within large litters showed a higher umbilical cord lactate level (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.01), lower average vitality score (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01), and a higher stillborn percentage (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.01) compared with piglets within medium size (16\u201318 piglets) and small litters. Each additional piglet born to a litter linearly decreased average piglet birth weight (17.6 g,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.01), increased farrowing duration (11 min,\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.01), and increased stillbirth (0.5%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04). A medium farrowing duration resulted in a lower stillborn percentage compared with a short or prolonged farrowing duration, suggesting that farrowing duration might have an optimum. When analyzed linearly, stillborn percentage increased with 1.85% per every 100 min (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.01) of farrowing duration. It can be concluded that both litter size and farrowing duration affect stillborn percentage, but independent from each other. However, these two factors tended to interact regarding pre-weaning mortality, suggesting that setting a certain threshold for maximal farrowing duration should be taken with care, because this appears to depend on litter size.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2022.836202","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T17:24:25Z","timestamp":1650561865000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Disentangling Litter Size and Farrowing Duration Effects on Piglet Stillbirth, Acid\u2013Base Blood Parameters and Pre-Weaning Mortality"],"prefix":"10.3389","volume":"9","author":[{"given":"Moniek","family":"van den Bosch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene B.","family":"van de Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"van den Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.2527\/jas.2005-775","article-title":"Between-breed variability of stillbirth and its relationship with sow and piglet characteristics","volume":"84","author":"Canario","year":"2006","journal-title":"J Anim Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1439-0531.2007.00887.x","article-title":"Mechanisms of regulation of litter size in pigs on the genome level","volume":"42","author":"Distl","year":"2007","journal-title":"Reprod Domestic 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