{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:48:47Z","timestamp":1781801327111,"version":"3.54.5"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p><jats:italic>Artemisia annua<\/jats:italic> L., which is known for its antimalarial compound artemisinin, has commonly been used for its anti-inflammatory and antibacterial functions. Enzymatically treating <jats:italic>Artemisia annua<\/jats:italic> L. can improve its bioavailability. The purpose of this study was to investigate the effects of dietary enzymatically treated <jats:italic>Artemisia annua<\/jats:italic> L. (EA) supplementation in late gestation and lactation diets on sow performance, serum hormone, inflammatory cytokines, and immunoglobulin level of heat-stressed sows. A total of 135 multiparous sows (Large White \u00d7 Landrace) on day 85 of gestation were selected and randomly distributed into 3 groups with 45 replicates per group. The control group was reared under standard conditions (temperature: 27.12 \u00b1 0.18\u00b0C, THI (temperature-humidity index): 70.90 \u00b1 0.80) and fed with basal diet. The heat stress (HS) and HS + EA groups were raised in heat-stressed conditions (temperature: 30.11 \u00b1 0.16\u00b0C, THI: 72.70 \u00b1 0.60) and fed with basal diets supplemented with 0 or 1.0 g\/kg EA, respectively. This trial lasted for 50 consecutive days until day 21 of lactation. Compared with the control group, HS increased the concentrations of serum endotoxin and heat shock protein 70 (HSP-70), and inflammatory cytokines in serum, colostrum, and 14 day milk of sows. Meanwhile, the EA supplementation decreased levels of serum endotoxin, HSP-70, and inflammatory cytokines in both sows and offspring and increased serum triiodothyronine (T<jats:sub>3<\/jats:sub>) level and average daily feed intake (ADFI) of sows. In addition, EA significantly improved average daily gain (ADG) and altered intestinal morphology with an increased villus height in the duodenum and ileum of piglets. Collectively, EA supplementation at 1.0 g\/kg in late gestation and lactation diets alleviated the adverse effects of HS, which were reflected by enhancing ADFI and decreasing endotoxin as well as inflammatory cytokine levels in the serum and colostrum of heat-stressed sows, while promoting ADG and gut development of their offspring.<\/jats:p>","DOI":"10.3389\/fvets.2022.843673","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T17:59:33Z","timestamp":1648576773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Dietary Supplementation of Enzymatically Treated Artemisia annua L. Improves Lactation Performance, Alleviates Inflammatory Response of Sows Reared Under Heat Stress, and Promotes Gut Development in Preweaning Offspring"],"prefix":"10.3389","volume":"9","author":[{"given":"Liang","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenFei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZheZhe","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WuTai","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiHai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0301-6226(97)00137-1","article-title":"Influence of high ambient temperature on performance of reproductive sows","volume":"52","author":"Prunier","year":"1997","journal-title":"Livest Prod Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.3382\/ps.2010-00812","article-title":"Heat stress impairs performance parameters, induces intestinal injury, and decreases macrophage activity in broiler chickens","volume":"89","author":"Quinteiro-Filho","year":"2010","journal-title":"Poult Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0739-7240(91)90046-m","article-title":"Endocrine changes in sows exposed to elevated ambient temperature during lactation","volume":"8","author":"Barb","year":"1991","journal-title":"Domest Anim Endocrin."},{"key":"B4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jtherbio.2017.07.015","article-title":"Dietary supplementation of enzymatically treated Artemisia annua could alleviate the intestinal inflammatory response in heat-stressed broilers","volume":"69","author":"Song","year":"2017","journal-title":"J Therm Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.anifeedsci.2016.07.014","article-title":"N-acetylcysteine improves the growth performance and intestinal function in the heat-stressed broilers","volume":"220","author":"Yi","year":"2016","journal-title":"Anim Feed Sci Tech."},{"key":"B6","doi-asserted-by":"publisher","first-page":"18872","DOI":"10.1038\/s41598-020-75885-x","article-title":"Chronic heat stress regulates the relation between heat shock protein and immunity in broiler small intestine","volume":"10","author":"Siddiqui","year":"2020","journal-title":"Sci Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"E52","DOI":"10.3168\/jds.S0022-0302(03)74040-5","article-title":"Economic losses from heat stress by US livestock industries1","volume":"86","author":"St-Pierre","year":"2003","journal-title":"J Dairy Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.2527\/2006.842360x","article-title":"Effects of breed and season on performance of lactating sows in a tropical humid climate","volume":"84","author":"Gourdine","year":"2006","journal-title":"J Anim Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s40104-020-00483-w","article-title":"Effect of dietary near ideal amino acid profile on heat production of lactating sows exposed to thermal neutral and heat stress conditions","volume":"11","author":"Zhang","year":"2020","journal-title":"J Anim Sci Biotechno."},{"key":"B10","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1146\/annurev-animal-031412-103644","article-title":"Effects of heat stress on postabsorptive metabolism and energetics","volume":"1","author":"Baumgard","year":"2013","journal-title":"Annu Rev Anim Biosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/mrd.22844","article-title":"Heat stress in pregnant sows: thermal responses and subsequent performance of sows and their offspring","volume":"84","author":"Lucy","year":"2017","journal-title":"Mol Reprod Dev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"102539","DOI":"10.1016\/j.jtherbio.2020.102539","article-title":"Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation","volume":"89","author":"Guo","year":"2020","journal-title":"J Therm Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/s1671-2927(11)60118-1","article-title":"Utilization of Chinese herbal feed additives in animal production","volume":"10","author":"Liu","year":"2011","journal-title":"Agr Sci China."},{"key":"B14","doi-asserted-by":"publisher","first-page":"4083","DOI":"10.5897\/AJB08.490","article-title":"Dietary inclusion of dried Artemisia annua leaves for management of coccidiosis and growth enhancement in chickens","volume":"7","author":"Brisibe","year":"2008","journal-title":"Afr J Biotechnol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"102751","DOI":"10.1016\/j.jtherbio.2020.102751","article-title":"Dietary enzymatically-treated Artemisia annua L. supplementation could alleviate oxidative injury and improve reproductive performance of sows reared under high ambient temperature","volume":"94","author":"Zhang","year":"2020","journal-title":"J Therm Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1021\/jf0624244","article-title":"Chemical composition and antimicrobial and antioxidant activities of the essential oil and methanol extract of Hippomarathrum microcarpum (Bieb.) from Turkey","volume":"55","author":"Ozer","year":"2007","journal-title":"J Agric Food Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5165","DOI":"10.1021\/jf010697n","article-title":"Antioxidant activity and phenolic compounds in selected herbs","volume":"49","author":"Zheng","year":"2001","journal-title":"J Agric Food Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/nm.2471","article-title":"The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine","volume":"17","author":"Tu","year":"2011","journal-title":"Nat Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1590\/1519-6984.232937","article-title":"Induction of secondary metabolites on nanoparticles stress in callus culture of Artemisia annua L","volume":"81","author":"Fatima","year":"2021","journal-title":"Braz J Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.vetpar.2011.11.058","article-title":"Use of Artemisia annua as a natural coccidiostat in free-range broilers and its effects on infection dynamics and performance","volume":"186","author":"Almeida","year":"2012","journal-title":"Vet Parasitol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"104221","DOI":"10.1016\/j.bioorg.2020.104221","article-title":"Structurally diverse sesquiterpenoids from the aerial parts of Artemisia annua (Qinghao) and their striking systemically anti-inflammatory activities","volume":"103","author":"Qin","year":"2020","journal-title":"Bioorg Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.3390\/molecules15053135","article-title":"Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer","volume":"15","author":"Ferreira","year":"2010","journal-title":"Molecules."},{"key":"B23","doi-asserted-by":"publisher","first-page":"844","DOI":"10.3382\/ps\/pew307","article-title":"Evaluation of enzymatically treated Artemisia annua L. on growth performance, meat quality, and oxidative stability of breast and thigh muscles in broilers","volume":"96","author":"Wan","year":"2017","journal-title":"Poult Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.anifeedsci.2016.08.017","article-title":"Antioxidant capacities of Artemisia annua L","volume":"221","author":"Wan","year":"2016","journal-title":"leaves and enzymatically treated Artemisia annua L. in vitro and in broilers. Anim Feed Sci Tech."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.3382\/ps.2013-03274","article-title":"Evaluation of the antioxidant effect of ganghwayakssuk (Artemisia princeps Pamp.) extract alone and in combination with ascorbic acid in raw chicken patties","volume":"92","author":"Hwang","year":"2013","journal-title":"Polut Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tibtech.2011.06.014","article-title":"Enzyme-assisted extraction of bioactives from plants","volume":"30","author":"Puri","year":"2012","journal-title":"Trends Biotechnol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12906-015-0887-x","article-title":"Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases","volume":"15","author":"Mahboubi","year":"2015","journal-title":"BMC Complem Altern M."},{"key":"B28","doi-asserted-by":"publisher","first-page":"377","DOI":"10.2527\/jas.2015-9623.","article-title":"High environmental temperature around farrowing induced heat stress in crated sows","volume":"94","author":"Muns","year":"2016","journal-title":"J Anim Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1017\/s1751731114001219","article-title":"Climatic effects on sow fertility and piglet survival under influence of a moderate climate","volume":"8","author":"Wegner","year":"2014","journal-title":"Animal."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.2527\/jas1982.5461212x","article-title":"Prolactin and luteinizing hormone secretion after bromocryptine (CB-154) treatment in lactating sows and ovariectomized gilts","volume":"54","author":"Kraeling","year":"1982","journal-title":"J Anim Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.2527\/1996.7451036x","article-title":"Influence of imposed feed intake patterns during lactation on reproductive performance and on circulating levels of glucose, insulin, and luteinizing hormone in primiparous sows","volume":"74","author":"Koketsu","year":"1996","journal-title":"J Anim Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.2527\/jas1987.6441060x","article-title":"Effect of protein and energy intake by primiparous sows during lactation on sow and litter performance and sow serum thyroxine and urea concentrations","volume":"64","author":"Brendemuhl","year":"1987","journal-title":"J Anim Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jtemb.2018.11.010","article-title":"Increasing selenium supply for heat-stressed or actively cooled sows improves piglet preweaning survival, colostrum and milk composition, as well as maternal selenium, antioxidant status and immunoglobulin transfer","volume":"52","author":"Chen","year":"2019","journal-title":"J Trace Elem Med Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.2527\/jas.2012-5796","article-title":"Early weaning increases intestinal permeability, alters expression of cytokine and tight junction proteins, and activates mitogen-activated protein kinases in pigs","volume":"91","author":"Hu","year":"2013","journal-title":"J Anim Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.anifeedsci.2013.08.001","article-title":"Cello-oligosaccharide ameliorates heat stress-induced impairment of intestinal microflora, morphology and barrier integrity in broilers","volume":"185","author":"Song","year":"2013","journal-title":"Anim Feed Sci Tech."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1017\/S1751731111000772","article-title":"Oxidative stress status of highly prolific sows during gestation and lactation","volume":"5","author":"Berchieri-Ronchi","year":"2011","journal-title":"Animal."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.2527\/jas.2015-0084","article-title":"Heat stress in pigs is accompanied by adipose tissue-specific responses that favor increased triglyceride storage","volume":"94","author":"Qu","year":"2016","journal-title":"J Anim Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0301-6226(93)90188-N","article-title":"Lactation in the sow during heat stress","volume":"35","author":"Black","year":"1993","journal-title":"Anim Feed Sci Tech."},{"key":"B39","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1093\/jas\/skab066","article-title":"Effects of cooled floor pads combined with chilled drinking water on behavior and performance of lactating sows under heat stress","volume":"99","author":"Zhu","year":"2021","journal-title":"J Anim Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.2527\/1999.7782124x","article-title":"Influence of high ambient temperatures on performance of multiparous lactating sows","volume":"77","author":"Quiniou","year":"1999","journal-title":"J Anim Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fvets.2020.00071","article-title":"The effects of dietary supplementation of Saccharomyces Cerevisiae fermentation product during late pregnancy and lactation on sow productivity, colostrum and milk composition, and antioxidant status of sows in a subtropical climate","volume":"7","author":"Chen","year":"2020","journal-title":"Front Vet Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3382\/ps.2012-02589","article-title":"Genetic variations alter production and behavioral responses following heat stress in 2 strains of laying hens","volume":"92","author":"Mack","year":"2013","journal-title":"Poult Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1017\/S1751731111002448","article-title":"Adaptation to hot climate and strategies to alleviate heat stress in livestock production","volume":"6","author":"Renaudeau","year":"2012","journal-title":"Animal."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1111\/asj.12766","article-title":"Effects of enzymatically treated Artemisia annua L. on growth performance and some blood parameters of broilers exposed to heat stress","volume":"88","author":"Wan","year":"2017","journal-title":"Anim Sci J."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1080\/1828051X.2020.1826364","article-title":"Effect of diet supplemented with enzymatically treated Artemisia annua L. on intestinal digestive function and immunity in weaned pigs","volume":"19","author":"Niu","year":"2020","journal-title":"Ital J Anim Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"103937","DOI":"10.1016\/j.livsci.2020.103937","article-title":"Dietary enzymatically treated Artemisia annua L. supplementation improved growth performance and intestinal antioxidant capacity of weaned piglets","volume":"232","author":"Niu","year":"2020","journal-title":"Livest Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.4081\/ijas.2015.4089","article-title":"Thyroid hormones in donkey blood and milk: correlations with milk yield and environmental temperatures","volume":"14","author":"Todini","year":"2015","journal-title":"Ital J Anim Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.domaniend.2015.02.001","article-title":"Environmental heat stress modulates thyroid status and its response to repeated endotoxin challenge in steers","volume":"52","author":"Kahl","year":"2015","journal-title":"Domest Anim Endocrinol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.aninu.2021.03.012","article-title":"Alterations of endotoxin distribution across different biofluids and relevant inflammatory responses by supplementing L-theanine in dairy cows during heat stress","volume":"7","author":"Wang","year":"2021","journal-title":"Anim Nutr."},{"key":"B50","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s40104-019-0391-0","article-title":"Heat stress affects fecal microbial and metabolic alterations of primiparous sows during late gestation","volume":"10","author":"He","year":"2019","journal-title":"J Anim Sci Biotechnol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.2527\/1998.7682017x","article-title":"Does feed restriction mimic the effects of increased ambient temperature in lactating sows?","volume":"76","author":"Messias de Bragan ca","year":"1998","journal-title":"J Anim Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/03079457.2012.696185","article-title":"The effect of Artemisia annua on broiler performance, on intestinal microbiota and on the course of a Clostridium perfringens infection applying a necrotic enteritis disease model","volume":"41","author":"Engberg","year":"2012","journal-title":"Avian Pathol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"115111","DOI":"10.1016\/j.envpol.2020.115111","article-title":"Heat stress during late gestation disrupts maternal microbial transmission with altered offspring's gut microbial colonization and serum metabolites in a pig model","volume":"266","author":"He","year":"2020","journal-title":"Environ Pollut"},{"key":"B54","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.2527\/jas.2015-9018","article-title":"Dietary organic zinc attenuates heat stress-induced changes in pig intestinal integrity and metabolism","volume":"93","author":"Pearce","year":"2015","journal-title":"J Anim Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1017\/S1751731114001268","article-title":"Heat stress upregulation of Toll-like receptors 2\/4 and acute inflammatory cytokines in peripheral blood mononuclear cell (PBMC) of Bama miniature pigs: an in vivo and in vitro study","volume":"8","author":"Ju","year":"2014","journal-title":"Animal."},{"key":"B56","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3382\/ps\/pex312","article-title":"Effects of dietary supplementation with enzymatically treated Artemisia annua on growth performance, intestinal morphology, digestive enzyme activities, immunity, and antioxidant capacity of heat-stressed broilers","volume":"97","author":"Song","year":"2018","journal-title":"Poult Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/biom11070975","article-title":"Phytochemical analysis and anti-inflammatory activity of different ethanolic phyto-extracts of Artemisia annua L","volume":"11","author":"Abate","year":"2021","journal-title":"Biomolecules."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.3390\/ani11061528","article-title":"Artemisinin protects porcine mammary epithelial cells against lipopolysaccharide-induced inflammatory injury by regulating the NF-\u03baB and MAPK signaling pathways","volume":"11","author":"Zhang","year":"2021","journal-title":"Animals"},{"key":"B59","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/1061186X.2019.1616296","article-title":"Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK\/NF-\u03baB\/NLRP3 inflammasomes pathway","volume":"28","author":"Jiang","year":"2020","journal-title":"J Drug Target."},{"key":"B60","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.taap.2015.04.005","article-title":"Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo","volume":"286","author":"Li","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2527\/jas.52339","article-title":"Heat stress reduces barrier function and alters intestinal metabolism in growing pigs","volume":"90","author":"Pearce","year":"2012","journal-title":"J Anim Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0148607197021006357","article-title":"Role of intestinal bacteria in nutrient metabolism","volume":"16","author":"Cummings","year":"1997","journal-title":"J Parenter Enteral Nutr."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.843673\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T17:59:35Z","timestamp":1648576775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.843673\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":62,"alternative-id":["10.3389\/fvets.2022.843673"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2022.843673","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"article-number":"843673"}}