{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:05:42Z","timestamp":1787061942446,"version":"build-2736575974"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>\n                    Poultry as a large-scale intensive farming is vulnerable to oxidative stress. Resveratrol and apigenin are recognized to have many beneficial bioactive functions. This study tested the hypothesis that dietary resveratrol and apigenin supplementation alleviates oxidative stress in the small intestine of diquat-challenged pullets. A total of 200 healthy pullets were randomly divided into four treatment groups: control group fed with a basal diet (CON), diquat group fed with a basal diet (DIQ), resveratrol group fed with a basal diet containing 500 mg\/kg resveratrol (RES), and an apigenin group fed with a basal diet containing 500 mg\/kg apigenin (API) and injected intraperitoneally with either 1 ml of saline (CON) or 8 mg\/kg body weight of diquat (DIQ, RES, and API) to induce oxidative stress. The day of the injection was considered as day 0. The results indicated that resveratrol and apigenin were able to decrease the malondialdehyde (MDA) level and upregulate total antioxidant capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) levels in serum on day 1 and 10 after being diquat-challenged. In addition, resveratrol increased mRNA expression of\n                    <jats:italic>NQO1<\/jats:italic>\n                    (NAD(P)H dehydrogenase quinone 1) and\n                    <jats:italic>HO-1<\/jats:italic>\n                    (heme oxygenase-1) in ileum and jejunum on day 10, while apigenin upregulated nuclear factor erythroid 2-related factor 2 (\n                    <jats:italic>NRF2<\/jats:italic>\n                    ),\n                    <jats:italic>NQO1<\/jats:italic>\n                    , and\n                    <jats:italic>HO-1<\/jats:italic>\n                    in ileum and jejunum on day 10. Both resveratrol and apigenin increased the mRNA expression of\n                    <jats:italic>CLAUDIN-1<\/jats:italic>\n                    in ileum and jejunum on day 1 and that of\n                    <jats:italic>ZO-1<\/jats:italic>\n                    (zonula occludens-1) in ileum on day 10 post-diquat-injection. These findings indicate that dietary supplementation with resveratrol and apigenin attenuates oxidative stress involving NRF2 signaling pathways in diquat-challenged pullets to some extent. These observations are valuable for the chicken industry and resveratrol and apigenin applications in animal husbandry.\n                  <\/jats:p>","DOI":"10.3389\/fvets.2022.850769","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T02:37:04Z","timestamp":1654051024000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Protective Effects of Resveratrol and Apigenin Dietary Supplementation on Serum Antioxidative Parameters and mRNAs Expression in the Small Intestines of Diquat-Challenged Pullets"],"prefix":"10.3389","volume":"9","author":[{"given":"Ning","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjiang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1111\/j.1439-0396.2008.00855.x","article-title":"The comparison of in vivo antigenotoxic and antioxidative capacity of two propylene glycol extracts of calendula officinalis (marigold) and vitamin E in young growing pigs","volume":"93","author":"Franki\u010d","year":"2010","journal-title":"J Anim Physiol Anim Nutr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"976753","DOI":"10.1155\/2012\/976753","article-title":"Reactive oxygen species in the signaling and adaptation of multicellular microbial communities","volume":"2012","author":"Cap","year":"2012","journal-title":"Oxid Med Cell Longev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"438","DOI":"10.9734\/BJMMR\/2015\/16284","article-title":"Free radicals: health implications and their mitigation by herbals","volume":"7","author":"Kumar","year":"2015","journal-title":"Br J Med Med Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.biopha.2015.07.025","article-title":"Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight","volume":"74","author":"Bhat","year":"2015","journal-title":"Biomed Pharmacother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1124\/jpet.111.180620","article-title":"Catalase and SOD conjugated with PECAM antibody distinctly alleviate abnormal endothelial permeability caused by exogenous ROS and vascular endothelial growth factor","volume":"378","author":"Han","year":"2011","journal-title":"J Pharmacol Exp Ther."},{"key":"B6","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1007\/s10495-012-0740-3","article-title":"Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage","volume":"17","author":"Zanichelli","year":"2012","journal-title":"Apoptosis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"14724","DOI":"10.1021\/acsami.7b03377","article-title":"Biogenic nanoselenium particles effectively attenuate oxidative stress-induced intestinal epithelial barrier injury by activating the Nrf2 antioxidant pathway","volume":"9","author":"Song","year":"2017","journal-title":"ACS Appl Mater Interfaces."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1007\/s00253-016-8032-4","article-title":"Bacillus amyloliquefaciens SC06 alleviates the oxidative stress of IPEC-1 via modulating Nrf2\/Keap1 signaling pathway and decreasing ROS production","volume":"101","author":"Wang","year":"2017","journal-title":"Appl Microbiol Biotechnol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11427-019-9591-5","article-title":"Oxidative stress, nutritional antioxidants and beyond","volume":"63","author":"Guo","year":"2020","journal-title":"Sci China."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1017\/S0954422410000077","article-title":"Nutritional programming of gastrointestinal tract development. 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