{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:19:46Z","timestamp":1790662786866,"version":"4.1.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 15-month-old male neutered Wirehaired Pointer mixed-breed dog presented with fever and cervical pain. Cerebrospinal fluid (CSF) analysis showed neutrophilic pleocytosis with intracellular bacteria, and culture of CSF grew <jats:italic>Bordetella bronchiseptica<\/jats:italic>. The patient became non-ambulatory 3 days after CSF collection. He was treated with low-dose prednisone for 3.5 months and doxycycline for 1 year. Recheck CSF analysis 1 month after diagnosis showed reduction of inflammation and 3 months after diagnosis revealed only increased protein. The patient improved neurologically over several months and was weakly ambulatory 5 months and fully ambulatory 7 months after diagnosis. Whole genome sequencing of the bacterial isolate and a live modified intranasal vaccine similar to the one the dog had been vaccinated with 7 weeks before diagnosis was similar but not an exact match. Bacterial meningitis should be considered, and culture of CSF is recommended, in cases of neutrophilic pleocytosis of CSF.<\/jats:p>","DOI":"10.3389\/fvets.2022.852982","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T07:36:23Z","timestamp":1649144183000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Bordetella bronchiseptica Meningoencephalomyelitis in a Dog"],"prefix":"10.3389","volume":"9","author":[{"given":"Helena","family":"Rylander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan M.","family":"Djani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Starr","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"B1","first-page":"1045","article-title":"Bacterial infections of the central nervous system.","volume-title":"Infectious Diseases of the Dog and Cat","author":"Kent","year":"2012"},{"key":"B2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1186\/s12917-020-02652-5","article-title":"Salmonella enterica subspecies houtenae as an opportunistic pathogen in a case of meningoencephalomyelitis and bacteriuria in a dog","volume":"16","author":"Andruzzi","year":"2020","journal-title":"BMC Vet Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1939-1676.1988.tb00312.x","article-title":"Central nervous-system infection associated with anaerobic bacteria in 2 dogs and 2 cats","volume":"2","author":"Dow","year":"1988","journal-title":"J Vet Intern Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"240","DOI":"10.2460\/javma.229.2.240","article-title":"Ventricular pneumocephalus and septic meningoencephalitis secondary to dorsal rhinotomy and nasal polypectomy in a dog","volume":"229","author":"Fletcher","year":"2006","journal-title":"J Am Vet Med A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"509","DOI":"10.5326\/15473317-33-6-509","article-title":"Flavobacterium breve meningitis in a dog","volume":"33","author":"Haburjak","year":"1997","journal-title":"J Am Anim Hosp Assoc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"290","DOI":"10.5326\/JAAHA-MS-7112","article-title":"Enterococcus spp. meningoencephalitis, ventriculitis, and hypophysitis in a dog","volume":"57","author":"Harvey","year":"2021","journal-title":"J Am Anim Hosp Assoc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.5326\/15473317-35-5-417","article-title":"Streptococcal meningoencephalitis in a dog","volume":"35","author":"Irwin","year":"1999","journal-title":"J Am Anim Hosp Assoc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1476-4431.2007.00245.x","article-title":"Brain abscess and bacterial endocarditis in a Kerry Blue terrier with a history of immune-mediated thrombocytopenia","volume":"17","author":"Bach","year":"2007","journal-title":"J Vet Emerg Crit Care."},{"key":"B9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1939-1676.1995.tb01089.x","article-title":"Diagnosis of inflammatory and infectious diseases of the central nervous system in dogs-a retrospective study","volume":"9","author":"Tipold","year":"1995","journal-title":"J Vet Intern Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1939-1676.2002.tb02348.x","article-title":"Bacterial meningoencephalomyelitis in dogs: a retrospective study of 23 cases (1990\u20131999)","volume":"16","author":"Radaelli","year":"2002","journal-title":"J Vet Intern Med."},{"key":"B11","first-page":"886","article-title":"Bacterial meningitis. 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