{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:43:50Z","timestamp":1793223830121,"version":"4.5.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A 10-year-old female goat was presented to the clinic with lethargy, emaciation, and pale mucous membranes. Laboratory diagnosis revealed severe anemia with regenerative character as well as melena. Blood transfusions were administered, but the animal's condition continued to deteriorate, so it was euthanized. The main finding in the necropsy was an abomasal neoplasia with two metastases in the mesenterium which was positive for vimentin, but negative for smooth muscle actin and c-kit using immunohistochemistry, indicating a fibrosarcoma that might have contributed to gastrointestinal blood loss. Further pathological findings consisted of changes in the liver cells as well as a cervical leiomyoma. These findings illustrate that intestinal blood loss due to neoplasia should also be considered in older goats with anemia.<\/jats:p>","DOI":"10.3389\/fvets.2022.869017","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T10:09:07Z","timestamp":1651140547000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Severe Anemia Associated With an Abomasal Fibrosarcoma in a Goat"],"prefix":"10.3389","volume":"9","author":[{"given":"Matthias Gerhard","family":"Wagener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Beythien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Sterneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Polifka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thekla","family":"Gro\u00dfmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Baumg\u00e4rtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ganter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3390\/ani11020363","article-title":"Haemonchosis: a challenging parasitic infection of sheep and goats","volume":"11","author":"Arsenopoulos","year":"2021","journal-title":"Animals."},{"key":"B2","unstructured":"Anemia in goats other than haemonchosis\n            NavarreCB\n          In; Large Animal Proceedings of the North American Veterinary Conference, vol 212007"},{"key":"B3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.19052\/mv.vol1.iss39.10","article-title":"Cutaneous fistula secondary to an abomasum ulcer in the goat: a case report","volume":"39","author":"Hern\u00e1ndez Molina","year":"2020","journal-title":"Rev de Med Vet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cvfa.2017.10.003","article-title":"Abomasal and third compartment ulcers in ruminants and South American camelids","volume":"34","author":"Hund","year":"2018","journal-title":"Vet Clin N Am Food Anim Pract."},{"key":"B5","first-page":"977","article-title":"Measurements of blood loss caused by haemonchus contortus infection in sheep","volume":"23","author":"Clark","year":"1962","journal-title":"Am J Vet Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s00436-011-2576-0","article-title":"Small ruminant resistance against gastrointestinal nematodes: a case of haemonchus contortus","volume":"109","author":"Saddiqi","year":"2011","journal-title":"Parasitol Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1017\/S0022149X07874232","article-title":"The Relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected with Fasciola hepatica","volume":"82","author":"Lotfollahzadeh","year":"2008","journal-title":"J Helminthol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0007-1935(17)43201-5","article-title":"Observations on the clinical pathology of ovine fascioliasis","volume":"118","author":"Sinclair","year":"1962","journal-title":"British Vet J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.3390\/ani11061819","article-title":"Current status for controlling the overlooked caprine fasciolosis","volume":"11","author":"Gemma","year":"2021","journal-title":"Animals."},{"key":"B10","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3390\/ani11020549","article-title":"Chronic wasting due to liver and rumen flukes in sheep","volume":"11","author":"Kahl","year":"2021","journal-title":"Animals."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.12681\/jhvms.18866","article-title":"Diagnostic approach of anemia in ruminants","volume":"69","author":"Katsogiannou","year":"2018","journal-title":"J Hell Vet Medical Soc."},{"key":"B12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.vetpar.2017.05.019","article-title":"Lice induced immuno-oxidative wreckage of goats","volume":"242","author":"Ajith","year":"2017","journal-title":"Vet Parasitol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.smallrumres.2016.03.005","article-title":"Haemoparasites in small ruminants in European countries: challenges and clinical relevance","volume":"142","author":"Stuen","year":"2016","journal-title":"Small Rum Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.3390\/ani10112179","article-title":"Haemoparasites\u2014challenging and wasting infections in small ruminants: a review","volume":"10","author":"Stuen","year":"2020","journal-title":"Animals."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13071-018-3269-7","article-title":"Epidemiology and genetic diversity of anaplasma ovis in goats in Corsica, France","volume":"12","author":"Cabezas-Cruz","year":"2019","journal-title":"Parasit Vectors."},{"key":"B16","first-page":"117","article-title":"Eperythrozoonosis in sheep","volume":"21","author":"Ganter","year":"1993","journal-title":"Tier\u00e4rztliche Praxis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1939-1676.1997.tb00486.x","article-title":"Hemolysis associated with water administration using a nipple bottle for human infants in juvenile pygmy goats","volume":"11","author":"Middleton","year":"1997","journal-title":"J Vet Intern Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0007-1935(91)90107-X","article-title":"Osmotic fragility of erythrocytes of west African dwarf sheep and goats: effects of temperature and Ph","volume":"147","author":"Oyewale","year":"1991","journal-title":"Br Vet J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1177\/104063870902100319","article-title":"Copper toxicosis with hemolysis and hemoglobinuric nephrosis in three adult boer goats","volume":"21","author":"Bozynski","year":"2009","journal-title":"J Vet Diagn Invest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1080\/00480169.1989.35592","article-title":"Chronic copper poisoning in angora kids","volume":"37","author":"Belford","year":"1989","journal-title":"N Z Vet J."},{"key":"B21","first-page":"4","article-title":"Copper toxicity in sheep","volume":"31","author":"Buck","year":"1969","journal-title":"Iowa State Univ Vet."},{"key":"B22","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tvjl.2009.03.002","article-title":"Animal poisoning in Europe. Part 1: farm livestock and poultry","volume":"183","author":"Guitart","year":"2010","journal-title":"Vet J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.cvfa.2020.10.004","article-title":"Hematologic conditions of small ruminants","volume":"37","author":"Johns","year":"2021","journal-title":"Vet Clin North Am Food Anim Pract."},{"key":"B24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1136\/vr.136.6.137","article-title":"Anaemia in housed newborn lambs","volume":"136","author":"Bassett","year":"1995","journal-title":"Vet Rec."},{"key":"B25","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1051\/rnd:2002022","article-title":"Copper deficiency in creole goat kids","volume":"42","author":"Draksler","year":"2002","journal-title":"Reprod Nutr Dev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0048-9697(99)00518-5","article-title":"Experimental copper and chromium deficiency and additional molybdenum supplementation in goats. II concentrations of trace and minor elements in liver, kidneys and ribs: haematology and clinical chemistry","volume":"249","author":"Frank","year":"2000","journal-title":"Sci Total Environm."},{"key":"B27","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/vr.109.3.51","article-title":"Thyroid status in cobalt and vitamin B12 deficiency in goats","volume":"109","author":"Mgongo","year":"1981","journal-title":"Vet Rec."},{"key":"B28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/BF00798359","article-title":"Myelofibrosis in young pygmy goats","volume":"4","author":"Cain","year":"1994","journal-title":"Comp Haematol Int."},{"key":"B29","first-page":"105","article-title":"Melanoma of foot in two local goats of kashmir-a case report","volume":"83","author":"Fazili","year":"2013","journal-title":"Vet Arh."},{"key":"B30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0021-9975(88)90022-9","article-title":"Malignant melanoma in goats: a clinico-pathological study","volume":"98","author":"Ramadan","year":"1988","journal-title":"J Comp Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.17236\/sat00111","article-title":"Clinical, sonographic and pathological findings in a saanen goat with mediastinal thymoma","volume":"159","author":"Braun","year":"2017","journal-title":"Schweizer Archiv f\u00fcr Tierheilkunde."},{"key":"B32","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1051\/vetres:2002036","article-title":"The famacha system for managing haemonchosis in sheep and goats by clinically identifying individual animals for treatment","volume":"33","author":"Van Wyk","year":"2002","journal-title":"Vet Res."},{"key":"B33","article-title":"The \u201cFAMACHA\u201d Ovine Anaemia Guide to assist with the control of haemonchosis","volume-title":"Proceedings of the 7th Annual Congress of the Livestock Health and Production Group of the South African Veterinary Association.","author":"Bath","year":"1996"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e000638","DOI":"10.1136\/vetreccr-2018-000638","article-title":"Anaemia in a llama (Lama glama): treatment, regeneration and differential diagnoses","volume":"6","author":"Wagener","year":"2018","journal-title":"Vet. Rec Case Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1024\/0036-7281.150.6.287","article-title":"H\u00e4matologische Und Klinisch-Chemische Referenzwerte F\u00fcr Adulte Ziegen Und Schafe","volume":"150","author":"Tschuor","year":"2008","journal-title":"Schweiz Arch Tierheilkd"},{"key":"B36","article-title":"H\u00e4mostase\u201c","volume-title":"Klinische Labordiagnostik in der Tiermedizin, 6th ed","author":"Mischke","year":"2005"},{"key":"B37","volume-title":"Mineral Levels in Animal Health: Diagnostik Data. 2nd ed","author":"Puls","year":"1994"},{"key":"B38","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1055\/a-0858-0545","article-title":"Dermal fibrosarcoma in a cashmere goat","volume":"47","author":"Schoiswohl","year":"2019","journal-title":"Tier\u00e4rztliche Praxis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1177\/0300985812471544","article-title":"One hundred two tumors in 100 goats (1987\u20132011)","volume":"50","author":"L\u00f6hr","year":"2013","journal-title":"Vet Pathol."},{"key":"B40","first-page":"195","article-title":"A Survey on neoplasia in domestic species over a 40-year period from 1935 to 1974 in the republic of South Africa. I tumours occurring in Cattle","volume":"49","author":"Bastianello","year":"1982","journal-title":"Onderstepoort J Vet Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1177\/1040638718759732","article-title":"Gastrointestinal spindle cell tumor of the rumen with metastasis to the liver in a goat","volume":"30","author":"Pesato","year":"2018","journal-title":"J Vet Diagn Invest."},{"key":"B42","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.tvjl.2007.06.013","article-title":"Kit-positive gastrointestinal stromal tumours in two spanish ibex (Capra Pyrenaica Hispanica)","volume":"177","author":"Velarde","year":"2008","journal-title":"Vet J."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e000515","DOI":"10.1136\/vetreccr-2017-000515","article-title":"Abomasal hamartoma in a la mancha wether","volume":"5","author":"Smith","year":"2017","journal-title":"Vet Rec Case Rep."},{"key":"B44","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0749-0720(15)30876-8","article-title":"Neoplasms of the bovine gastrointestinal tract","volume":"6","author":"Bertone","year":"1990","journal-title":"Vet Clin North Am Food Anim Pract."},{"key":"B45","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S0021-9975(03)00067-7","article-title":"Smooth muscle hamartoma of the abomasum in a Calf","volume":"130","author":"Yamaguchi","year":"2004","journal-title":"J Comp Pathol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jcpa.2010.11.002","article-title":"A retrospective study of 586 tumours in Brazilian cattle","volume":"145","author":"Lucena","year":"2011","journal-title":"J Comp Pathol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/00480169.1971.33920","article-title":"Neoplasms in cattle: a survey of 372 neoplasms examined at the ruakura veterinary diagnostic station","volume":"19","author":"Shortridge","year":"1971","journal-title":"N Z Vet J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1177\/104063870701900518","article-title":"Abomasal and uterine adenocarcinomas with ovarian metastasis in a captive Elk (Cervus Elaphus Nelsoni)","volume":"19","author":"Duncan","year":"2007","journal-title":"J Vet Diag Invest."},{"key":"B49","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/jnci\/59.1.185","article-title":"Nature and rate of neoplasia found in captive wild mammals, birds, and reptiles at necropsy","volume":"59","author":"Effron","year":"1977","journal-title":"J Natl Cancer Inst."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1080\/09712119.2018.1495644","article-title":"Omaso-abomasal adenocarcinoma in a female arabian camel (Camelus Dromedarius)","volume":"46","author":"Tharwat","year":"2018","journal-title":"J Appl Anim Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1111\/j.1939-1676.2009.0356.x","article-title":"Gastric neoplasia in horses","volume":"23","author":"Taylor","year":"2009","journal-title":"J Vet Int Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1097\/00000478-199112000-00005","article-title":"Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor","volume":"15","author":"Meis","year":"1991","journal-title":"Am J Surg pathol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cvsm.2012.04.006","article-title":"Alimentary neoplasia in geriatric dogs and cats","volume":"42","author":"Willard","year":"2012","journal-title":"Vet Clin North Am Small Anim Pract."},{"key":"B54","doi-asserted-by":"publisher","first-page":"808","DOI":"10.2460\/javma.256.7.808","article-title":"Neoplasia of the tubular genital tract in 42 Goats","volume":"256","author":"Linton","year":"2020","journal-title":"J Am Vet Med Assoc."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.869017\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T10:09:38Z","timestamp":1651140578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.869017\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":54,"alternative-id":["10.3389\/fvets.2022.869017"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2022.869017","relation":{},"ISSN":["2297-1769"],"issn-type":[{"value":"2297-1769","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,28]]},"article-number":"869017"}}