{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T09:40:04Z","timestamp":1783244404729,"version":"3.54.6"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>This study was to investigate effects of zinc oxide nanoparticle (Nano-ZnO) on growth, immunity, intestinal morphology and function of intrauterine growth retardation (IUGR) finishing pigs. Six normal birth weight (NBW) and 12 IUGR male piglets were obtained and weaned at 21 d. NBW-weaned piglets fed basal diets (NBW group), IUGR-weaned piglets allocated to two groups fed basal diets (IUGR group) and basal diets further supplemented 600 mg Zn\/kg from Nano-ZnO (IUGR+Zn group), respectively. All pigs were slaughtered at 163 d. Results showed: (1) IUGR pigs showed no difference in body weight at 77d and 163d (<jats:italic>P<\/jats:italic> &amp;gt; 0.05), while had increased villus height (VH) and villus surface area in jejunum (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) and enhanced interleukin-6, TNF-\u03b1 and NF-\u03baB mRNA expression (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) as compared to NBW group; Compared with IUGR group, dietary Nano-ZnO did not affect the body weight (<jats:italic>P<\/jats:italic> &amp;gt; 0.05), but increased VH to crypt depth ratio and IgA concentration (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) and decreased TNF-\u03b1 and NF-\u03baB mRNA expression in jejunum (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). (2) IUGR increased the number of swollen mitochondria and autolysosomes, and protein expressions of sequestosome-1 (P62) and microtubule-associated protein light chain 3 B\/A (LC3B\/A) in jejunum as compared to NBW group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05); Compared with IUGR group, Nano-ZnO decreased the number of swollen mitochondria and autolysosomes, and P62 and LC3B\/A protein expression (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). (3) IUGR increased mucosal contents of malondialdehyde and protein carbonyl (PC) and Keap1 protein expression (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) as compared to NBW group; Compared with IUGR group, dietary Nano-ZnO increased activities of total antioxidant capacity, catalase, glutathione peroxidase, and glutathione content (<jats:italic>P<\/jats:italic> &amp;lt; 0.05), and enhanced nuclear respiratory factor 2 (Nrf2), glutamate-cysteine ligase modifier subunit and glutathione peroxidase 1 mRNA expression, and increased total and nuclear Nrf2 protein expression (<jats:italic>P<\/jats:italic> &amp;lt; 0.05), and decreased malondialdehyde and PC content, and Keap1 protein expression (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) in jejunum. Results suggested that IUGR pigs showed postnatal catch-up growth and improved intestinal morphology, and dietary Nano-ZnO may further improve intestinal morphology, reduce inflammation, decrease autophagy and alleviate oxidative stress via Nrf2\/Keap1 pathway in jejunum of IUGR pigs.<\/jats:p>","DOI":"10.3389\/fvets.2022.884945","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T07:19:41Z","timestamp":1654499981000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Zinc Oxide Nanoparticle Improves the Intestinal Function of Intrauterine Growth Retardation Finishing Pigs via Regulating Intestinal Morphology, Inflammation, Antioxidant Status and Autophagy"],"prefix":"10.3389","volume":"9","author":[{"given":"Binbin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.2527\/jas.2006-156","article-title":"Board-invited 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