{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:35:34Z","timestamp":1753893334173,"version":"3.41.2"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005629","name":"Stiftung Tier\u00e4rztliche Hochschule Hannover","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005629","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>A male 10-year-old captive red kangaroo (<jats:italic>Macropus rufus<\/jats:italic>) was presented with a chronic progressive pelvic limb lameness and reluctance to jump. The general examination revealed a palpable induration of the lumbar epaxial muscles. Magnetic resonance imaging performed under general anesthesia revealed bilateral almost symmetric, well-circumscribed mass lesions in superficial erector spinae muscles. The lesions had irregular to multilobulated appearance with hyper-, hypo-, and isointense areas in T2- and T1-weighted (w) sequences without contrast enhancement. On computed tomography, a peripheral rim of mineralization was apparent. Histopathological analysis of a muscle biopsy showed osseous trabeculae with rare clusters of chondrocytes indicating metaplasia of muscle tissue to bone. No indications of inflammation or malignancy were visible. The clinical, histopathological, and imaging workup of this case was consistent with<jats:italic>myositis ossificans circumscripta<\/jats:italic>. This disorder is particularly well-known among human professional athletes such as basketball players, where excessive, chronic-repetitive force or blunt trauma causes microtrauma to the musculature. Metaplasia of muscle tissue due to abnormal regeneration processes causes heterotopic ossification. The kangaroo's clinical signs improved with cyto-reductive surgery, cage rest, weight reduction, and meloxicam without further relapse.<\/jats:p>","DOI":"10.3389\/fvets.2022.886495","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T15:24:54Z","timestamp":1657034694000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Unable to Jump Like a Kangaroo Due to Myositis Ossificans Circumscripta"],"prefix":"10.3389","volume":"9","author":[{"given":"Enrice I.","family":"Huenerfauth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Moln\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Ciurkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz J.","family":"S\u00f6bbeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Harms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Baumg\u00e4rtner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tipold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger A.","family":"Volk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Nessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"volume-title":"The Complete Guide to the Care of Macropods","year":"2006","author":"Staker","key":"B1"},{"key":"B2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/avj.12849","article-title":"Metastatic osteolytic angioleiomyosarcoma induced by a foreign body in a kangaroo (Macropus giganteus)","volume":"97","author":"Setyo","year":"2019","journal-title":"Aust Vet J."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1638\/05-053.1","article-title":"Fluorosis as a probable cause of chronic lameness in free ranging eastern grey kangaroos","author":"Clarke","year":"2006","journal-title":"J Zoo Wildl Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1177\/104063871002200232","article-title":"A retrospective study of disease in captive kangaroos from Oklahoma State University, 1995-2009","volume":"22","author":"Stern","year":"2010","journal-title":"J Vet Diagn Invest."},{"key":"B5","doi-asserted-by":"publisher","first-page":"coz027","DOI":"10.1093\/conphys\/coz027","article-title":"Conserving wildlife in a changing world: Understanding capture myopathy-a malignant outcome of stress during capture and translocation","volume":"7","author":"Breed","year":"2019","journal-title":"Conserv physiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"612","DOI":"10.5435\/JAAOS-D-14-00269","article-title":"Myositis Ossificans","volume":"23","author":"Walczak","year":"2015","journal-title":"J Am Acad Orthop Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.2214\/ajr.157.6.1950874","article-title":"Myositis ossificans: MR appearance with radiologic-pathologic correlation","volume":"157","author":"Kransdorf","year":"1991","journal-title":"AJR Am J Roentgenol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-195840020-00004","article-title":"Extra-osseous localized non-neoplastic bone and cartilage formation (so-called myositis ossificans): clinical and pathological confusion with malignant neoplasms","author":"Ackerman","year":"1958","journal-title":"J Bone Joint Surg Am"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1053\/crad.2002.1120","article-title":"The imaging features of post-traumatic myositis ossificans, with emphasis on MRI","volume":"57","author":"Parikh","year":"2002","journal-title":"Clin Radiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3928\/01477447-20110124-08","article-title":"Heterotopic ossification revisited","volume":"34","author":"Mavrogenis","year":"2011","journal-title":"Orthopedics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1249\/JSR.0000000000000515","article-title":"Myositis ossificans in sport: a review","volume":"17","author":"Devilbiss","year":"2018","journal-title":"Curr Sports Med Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1148\/rg.2018170072","article-title":"Imaging of muscle trauma: anatomy, biomechanics, pathophysiology, and imaging appearance","volume":"38","author":"Flores","year":"2018","journal-title":"RadioGraphics."},{"key":"B13","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3415\/VCOT-12-02-0029","article-title":"Myositis ossificans circumscripta of the triceps muscle in a Rottweiler dog","volume":"26","author":"Tambella","year":"2013","journal-title":"Vet Comp Orthop Traumatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1532-950X.2007.00357.x","article-title":"Sartorius muscle contracture in a German shepherd dog","volume":"37","author":"Spadari","year":"2008","journal-title":"Vet Surg."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.2460\/javma.2004.224.1630","article-title":"Gracilis muscle injury as a cause of lameness in two horses","volume":"3","author":"Dabareiner","year":"2004","journal-title":"J Am Vet Med Assoc"},{"key":"B16","first-page":"289","article-title":"Kinematic characteristics of myositis ossificans of the semimembranosus muscle in a dog","volume":"51","author":"Vilar","year":"2010","journal-title":"Can Vet J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.5326\/15473317-33-2-177","article-title":"Gracilis or semitendinosus myopathy in 18 dogs","volume":"33","author":"Lewis","year":"1997","journal-title":"J Am Anim Hosp Assoc."},{"key":"B18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/j.1748-5827.1976.tb06973.x","article-title":"A condition resembling human localized myositis ossificans in two dogs","volume":"17","author":"Liu","year":"1976","journal-title":"J Small Anim Pract."},{"key":"B19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2460\/javma.1990.197.03.383","article-title":"von Willebrand heterotopic osteochondrofibrosis in Doberman pinschers: five cases (1980-1987)","volume":"197","author":"Dueland","year":"1990","journal-title":"J Am Vet Med Assoc."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198208000-00035","article-title":"Myositis ossificans: radiologic evaluation of two cases with diagnostic computed tomograms","author":"Zeanah","year":"1982","journal-title":"Clin Orthop Relat Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1046\/j.1442-9993.1999.241949.x","article-title":"Body condition of the red kangaroo (Macropus rufus) in arid Australia: The effect of environmental condition, sex and reproduction","volume":"24","author":"Moss","year":"1999","journal-title":"Austral Ecol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2981\/wlb.00692","article-title":"Reference intervals for parameters of health of eastern grey kangaroos Macropus giganteus and management implications across their geographic range","volume":"2020","author":"Brandimarti","year":"2020","journal-title":"Wildlife Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1071\/AM17002","article-title":"Blood constituents of free-ranging eastern grey kangaroos (Macropus giganteus)","volume":"40","author":"Green-Barber","year":"2017","journal-title":"Australian Mammal."},{"key":"B24","unstructured":"ClarkP Clayton, AustraliaCSIRO PublishingHaematology of Australian Mammals2004"},{"key":"B25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1179\/his.2008.31.3.101","article-title":"Muscle biopsy: a diagnostic tool in muscle diseases","volume":"31","author":"Nowak","year":"2008","journal-title":"J Histotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.jbspin.2015.07.013","article-title":"Myositis ossificans traumatica (circumscripta) and return to sport: a retrospective series of 19 cases","volume":"83","author":"Simon","year":"2016","journal-title":"Joint Bone Spine."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1002\/jbmr.1691","article-title":"The role of endothelial-mesenchymal transition in heterotopic ossification","volume":"27","author":"Medici","year":"2012","journal-title":"J Bone Miner Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/term.173","article-title":"Progenitor and stem cells for bone and cartilage regeneration","volume":"3","author":"El Tamer","year":"2009","journal-title":"J Tissue Eng Regen Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3389\/fphys.2017.00194","article-title":"Defining the balance between regeneration and pathological ossification in skeletal muscle following traumatic injury","volume":"8","author":"Davies","year":"2017","journal-title":"Front Physiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1136\/bjsm.32.4.287","article-title":"Post-traumatic ectopic calcification in the muscles of athletes: a review","volume":"32","author":"King","year":"1998","journal-title":"BJSM."},{"key":"B31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.12659\/AJCR.891151","article-title":"Non-traumatic myositis ossificans in the lumbar spine","volume":"15","author":"Abdallah","year":"2014","journal-title":"Am J Case Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/01.CSMR.0000434055.36042.cd","article-title":"Basketball Injuries: caring for a basketball team","volume":"12","author":"Trojian","year":"2013","journal-title":"Curr Sports Med Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4103\/0973-6042.94315","article-title":"Myositis ossificans circumscripta of the triceps due to overuse in a female swimmer","volume":"6","author":"Defoort","year":"2012","journal-title":"Int J Shoulder Surg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/joa.13323","article-title":"Morphometry of the kangaroo spine and its comparison with human spinal data","volume":"238","author":"Wilke","year":"2021","journal-title":"J Anat."},{"key":"B35","doi-asserted-by":"publisher","first-page":"921","DOI":"10.12688\/f1000research.11712.1","article-title":"A bipedal mammalian model for spinal cord injury research: the tammar wallaby","volume":"6","author":"Saunders","year":"2017","journal-title":"F1000Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1007\/s00586-016-4776-x","article-title":"Thoracic spine morphology of a pseudo-biped animal model (kangaroo) and comparisons with human and quadruped animals","volume":"25","author":"Balasubramanian","year":"2016","journal-title":"Eur Spine J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1298","DOI":"10.1259\/bjr\/14063641","article-title":"Skeletal muscle disease: patterns of MRI appearances","volume":"85","author":"Theodorou","year":"2012","journal-title":"Br J Radiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13005-018-0180-6","article-title":"Myositis ossificans traumatica of the masticatory muscles: etiology, diagnosis and treatment","volume":"14","author":"Hanisch","year":"2018","journal-title":"Head Face Med."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fjs.2015.06.004","article-title":"Abdominis rectus intramuscular myositis ossificans","author":"Li","year":"2016","journal-title":"Formos J Surg"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1638\/2009-0148.1","article-title":"Toxoplasmosis in macropodids: a review","volume":"41","author":"Portas","year":"2010","journal-title":"J Zoo Wildl Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"7454376","DOI":"10.1155\/2017\/7454376","article-title":"The synergistic interplay between vitamins d and k for bone and cardiovascular health: a narrative review","volume":"2017","author":"van Ballegooijen","year":"2017","journal-title":"Int J Endocrinol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fendo.2012.00095","article-title":"Mechanisms and clinical consequences of vascular calcification","volume":"3","author":"Zhu","year":"2012","journal-title":"Front Endocrinol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4103\/0971-6580.75851","article-title":"Clinicopathological studies on vitamin D(3) toxicity and therapeutic evaluation of aloe vera in rats","volume":"18","author":"Chavhan","year":"2011","journal-title":"Toxicol Int"},{"volume-title":"Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat","year":"","author":"Ettinger","key":"B44"},{"key":"B45","doi-asserted-by":"publisher","first-page":"242","DOI":"10.5582\/irdr.2017.01055","article-title":"Fibrodysplasia ossificans progressiva: Basic understanding and experimental models","volume":"6","author":"Qi","year":"2017","journal-title":"Intractable Rare Dis Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/dvdy.24606","article-title":"Animal models of fibrodysplasia ossificans progressiva","volume":"247","author":"LaBonty","year":"2018","journal-title":"Dev Dyn."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2055116919839857","DOI":"10.1177\/2055116919839857","article-title":"Bilateral fibrodysplasia ossificans affecting the masticatory muscles and causing irreversible trismus in a domestic shorthair cat","volume":"5","author":"Guzu","year":"2019","journal-title":"JFMS Open Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"303ra137","DOI":"10.1126\/scitranslmed.aac4358","article-title":"ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A","volume":"7","author":"Hatsell","year":"2015","journal-title":"Sci Transl Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jtemb.2016.10.001","article-title":"Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): a case control study","volume":"39","author":"Hildebrand","year":"2017","journal-title":"J Trace Elem Med Biol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s00256-018-2889-5","article-title":"Fibrodysplasia ossificans progressiva: a current review of imaging findings","volume":"47","author":"Bauer","year":"2018","journal-title":"Skeletal Radiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1750-1172-6-80","article-title":"Fibrodysplasia ossificans progressiva: clinical and genetic aspects","volume":"6","author":"Pignolo","year":"2011","journal-title":"Orphanet J Rare Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1292\/jvms.001649","article-title":"Fibrodysplasia ossificans progressiva in a Maine Coon cat with prominent ossification in dorsal muscle","volume":"71","author":"Yabuzoe","year":"2009","journal-title":"J Vet Med Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/vru.12040","article-title":"Imaging diagnosis: fibrodysplasia ossificans progressiva in a cat","volume":"54","author":"Klang","year":"2013","journal-title":"Vet Radiol Ultrasound."},{"key":"B54","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3354\/dao02538","article-title":"Severe soft tissue ossification in a southern right whale Eubalaena australis","volume":"102","author":"La Sala","year":"2012","journal-title":"Dis Aquat Organ."},{"key":"B55","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/030098586700400108","article-title":"Generalized myositis ossificans (familial) in pigs","volume":"4","author":"Seibold","year":"1967","journal-title":"Pathol Vet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1939-1676.1992.tb00366.x","article-title":"Fibrodysplasia ossificans progressiva in the cat. A case report","volume":"6","author":"Valentine","year":"1992","journal-title":"J Vet Intern Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1177\/030098588402100507","article-title":"Fibrodysplasia ossificans in three cats","volume":"21","author":"Warren","year":"1984","journal-title":"Vet Pathol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.1748-5827.2001.tb06026.x","article-title":"Fibrodysplasia ossificans in a German shepherd dog","volume":"42","author":"Guilliard","year":"2001","journal-title":"J Small Anim Pract."},{"key":"B59","doi-asserted-by":"publisher","first-page":"686","DOI":"10.2106\/JBJS.I.00705","article-title":"Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva","volume":"92","author":"Kaplan","year":"2010","journal-title":"J Bone Joint Surg Am."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.886495\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T14:21:32Z","timestamp":1727533292000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.886495\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":59,"alternative-id":["10.3389\/fvets.2022.886495"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2022.886495","relation":{},"ISSN":["2297-1769"],"issn-type":[{"type":"electronic","value":"2297-1769"}],"subject":[],"published":{"date-parts":[[2022,7,4]]},"article-number":"886495"}}