{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:30:43Z","timestamp":1787027443709,"version":"build-2736575974"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["No. NRF-2021R1F1A1061799"],"award-info":[{"award-number":["No. NRF-2021R1F1A1061799"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>There is only one previous report of canine goitrous hypothyroidism caused by iodine deficiency from 1986. The present case report describes the novel diagnostic methods and long-term outcomes of a dog diagnosed with goitrous hypothyroidism caused by iodine deficiency. A 4-year-old neutered, female Pomeranian dog presented with a cervical mass, lethargy, and inactivity. The dog had a history of eating home-cooked diets sold by a private seller for 1 year. The physical examination and ultrasonography showed two bilaterally symmetric masses in the mid-cervical area (left, 1.8 \u00d7 1.4 cm; right, 2.3 \u00d7 1.8 cm), and they were suspected to be the thyroid glands. To identify the function of the thyroid gland, the basal concentrations of thyroid hormones [total T4 (tT4) and thyroid-stimulating hormone (TSH)] were measured and a TSH stimulation test was performed: baseline tT4, 0.5 \u03bcg\/dL (reference interval, 1\u20134 \u03bcg\/dL), baseline TSH, 0.81 \u03bcg\/dL (reference interval, 0.05\u20130.42 \u03bcg\/dL), and post-tT4, 1 \u03bcg\/dL (6 h after the injection of TSH). The values indicated primary hypothyroidism. The urinary iodine concentration was 302 \u03bcg\/L, which was markedly lower than that of normal dogs (1,289 \u03bcg\/L). Thyroid scintigraphy with technetium-99m pertechnetate was also performed to quantify the activity of the thyroid gland, and the thyroid-to-salivary ratio was 3.35. Based on the results of these examinations and patient history, the dog was diagnosed with diet-induced (iodine deficiency) goitrous hypothyroidism. The dog was treated with iodine (62.5 \u03bcg\/day). At 31 days after treatment, clinical signs and thyroid hormones were normalized (tT4, 1.3 \u03bcg\/dL; TSH, 0.24 \u03bcg\/dL). One year after treatment, the dog was well with normal concentrations of thyroid hormones (tT4, 1.8 \u03bcg\/dL; TSH, 0.27 \u03bcg\/dL) and a partially reduced goiter (left, 1.6 \u00d7 1.1 cm; right, 1.2 \u00d7 0.9 cm). This is the first case to describe novel diagnostic methods and long-term outcomes of a dog diagnosed with goitrous hypothyroidism caused by iodine deficiency.<\/jats:p>","DOI":"10.3389\/fvets.2022.922456","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T01:53:37Z","timestamp":1655085217000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Technetium-99m Pertechnetate Scintigraphy Findings in a Dog With Iodine Deficiency-Induced Goitrous 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