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Sci."],"abstract":"<jats:p>This experiment aims to investigate the effect of maternal diet supplemented with <jats:italic>Forsythia suspensa<\/jats:italic> extract (FSE) on the performance, antioxidant status, inflammatory responses, intestinal development, and microbial community of sows. A total of 24 gestating sows (Landrace \u00d7 Yorkshire) were assigned to 2 treatments with 12 sows per treatment. From d 107 of gestation to d 21 of lactation, sows were supplemented with a basal diet as control (CON) or an FSE diet (basal diet + 100 mg\/kg FSE). Compared with CON, sows fed FSE showed lower (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) wean-to-estrus interval, body weight loss, and higher (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) average daily gain of suckling piglet. Sows fed FSE had reduced (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) serum malondialdehyde (MDA) content and enhanced (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) catalase and glutathione peroxidase (GSH-Px) contents at farrowing and weaning compared with CON. The suckling piglets of FSE-fed sows had increased (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) mRNA expressions of nuclear factor erythroid-2 related factor 2, heme oxygenase-1 in the liver, and lower (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) serum MDA content on d 0, 7, and 14 of lactation. Sows fed FSE had lower (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) serum tumor necrosis factor-\u03b1 (TNF-\u03b1) and interleukin-8 (IL-8) contents at farrowing and reduced (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) serum IL-6 and IL-8 contents at weaning compared with CON. Piglets from FSE-fed sows had enhanced (<jats:italic>P<\/jats:italic> \u2264 0.05) villus height and villus height to crypt depth ratio in the jejunum, and higher (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) protein expression of Occludin in jejunal mucosa compared with CON. Sows fed FSE tended to have higher (<jats:italic>P<\/jats:italic> = 0.09) relative abundance of <jats:italic>Lactobacillus<\/jats:italic> at genus level in feces at weaning compared with CON. Our results showed maternal diet supplemented with FSE in lactating sows could effectively induce improvement of performance, antioxidant status, anti-inflammatory function, intestinal morphology, barrier function, and microbial community.<\/jats:p>","DOI":"10.3389\/fvets.2022.926822","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:30:44Z","timestamp":1657866644000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Maternal Dietary Forsythia suspensa Extract Supplementation Induces Changes in Offspring Antioxidant Status, Inflammatory Responses, Intestinal Development, and Microbial Community of 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