{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:36:11Z","timestamp":1783460171695,"version":"3.55.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>Weaning often induces oxidative stress and inflammatory response in piglets. This study investigated the effects of dietary licorice flavonoids powder (LFP) supplementation on antioxidant capacity and immunity in weaned piglets. Notably, 96 Landrace \u00d7 Yorkshire \u00d7 Duroc (DLY) weaned piglets were randomly allocated to four treatments with 6 replicates (4 animals per replicate) and fed with diet supplementation with 0, 50, 150, and 250 mg\/kg LFP, respectively. The trial lasted for 5 weeks. The results showed that dietary LFP supplementation effectively increased the liver index (<jats:italic>P<\/jats:italic>&amp;lt; 0.05). In addition, dietary LFP supplementation reduced serum aspartate aminotransferase activity (<jats:italic>P<\/jats:italic>&amp;lt; 0.01). Piglets fed with 50 mg\/kg LFP decreased total cholesterol and HDL-C content in serum (<jats:italic>P<\/jats:italic>&amp;lt; 0.05) and increased serum alkaline phosphatase activity (<jats:italic>P<\/jats:italic>&amp;lt; 0.01). Similarly, supplementation with 150 mg\/kg LFP elevated the activity of total antioxidant capability (T-AOC) in serum (<jats:italic>P<\/jats:italic>&amp;lt; 0.01) and dietary with 150 and 250 mg\/kg LFP increased T-AOC activity in spleen (<jats:italic>P<\/jats:italic>&amp;lt; 0.01). Moreover, dietary with 150 mg\/kg LFP addition enhanced (<jats:italic>P<\/jats:italic>&amp;lt; 0.05) the serum IgG content of piglets. Additionally, compared with the control group, dietary 250 mg\/kg LFP supplementation upregulated (<jats:italic>P<\/jats:italic>&amp;lt; 0.05) the mRNA abundance of<jats:italic>Interleukin<\/jats:italic>(<jats:italic>IL)-1<\/jats:italic>\u03b2 and<jats:italic>monocyte chemoattractant protein 1 (MCP-1)<\/jats:italic>in the spleen. Meanwhile, dietary 150 and 250 mg\/kg LFP supplementation downregulated (<jats:italic>P<\/jats:italic>&amp;lt; 0.05) mRNA abundance of<jats:italic>IL-10<\/jats:italic>, and<jats:italic>MCP-1<\/jats:italic>and 250 mg\/kg LFP upregulated (<jats:italic>P<\/jats:italic>&amp;lt; 0.05) the expression of<jats:italic>intercellular adhesion molecule 1 (ICAM-1), IL-1<\/jats:italic>\u03b2,<jats:italic>IL-6<\/jats:italic>, and<jats:italic>tumor necrosis factor<\/jats:italic>\u03b1<jats:italic>(TNF-<\/jats:italic>\u03b1<jats:italic>)<\/jats:italic>in the thymus. In conclusion, LFP supplementation improved the immune function of piglets by regulating the activity of serum biochemical enzymes, improving the antioxidant capacity, and alleviating inflammation of immune organs. This study indicated that LFP is potential alternative protection against early weaned stress in piglets.<\/jats:p>","DOI":"10.3389\/fvets.2022.942253","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T06:43:37Z","timestamp":1658817817000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Dietary licorice flavonoids powder improves serum antioxidant capacity and immune organ inflammatory responses in weaned piglets"],"prefix":"10.3389","volume":"9","author":[{"given":"Shenggang","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangmang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/2049-1891-4-19","article-title":"The biological stress of early weaned piglets","volume":"4","author":"Campbell","year":"2013","journal-title":"J Anim Sci Biotechnol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"494","DOI":"10.2527\/2002.802494x","article-title":"Effect of spray-dried plasma and lipopolysaccharide exposure on weaned pigs: I. 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