{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T17:08:27Z","timestamp":1763831307198,"version":"3.41.2"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Vet. Sci."],"abstract":"<jats:p>An 8-month-old female Main Coon with a history of recurrent behavioral changes and anorexia was presented with sternal recumbency and depression. Within 5 days, the cat progressively worsened with symptoms of stupor and coma and was euthanized. At post-mortem examination, a solid, grayish infratentorial mass located in the midline rostrally to the cerebellum, was observed. Histologically, highly cellular clusters of small-to-medium undifferentiated cells were intermingled with paucicellular areas with fibrillary eosinophilic (neuropil-like) appearance. Numerous multilayered (ependymoblastic) true rosettes were present. The mitotic activity was frequent (up to 15 mitoses\/HPF), involving both undifferentiated cells and rosettes. By immunohistochemistry (IHC), tumor cells were diffusely positive for vimentin, variably for synaptophysin, S-100, and NSE, and focally for NeuN; they were negative for GFAP and CK AE1\/AE3. The histological and IHC aspects were consistent with an Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR). Embryonal neoplasms of the central nervous system (CNS) are characterized by primitive undifferentiated cells, able to develop toward neuronal, glial, ependymal, and mesenchymal lines. Although extremely rare, juvenile embryonal tumors should be considered in the differentials of CNS disorders in young cats.<\/jats:p>","DOI":"10.3389\/fvets.2022.961056","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T08:40:19Z","timestamp":1661416819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Infratentorial Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR) in an 8-month-old Maine Coon"],"prefix":"10.3389","volume":"9","author":[{"given":"Greta","family":"Foiani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Mandara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carminato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Melchiotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Corr\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Vascellari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"volume-title":"Histological Classification of Tumors of the Nervous System of Domestic Animals","year":"1999","author":"Koestner","key":"B1"},{"volume-title":"Neuropatologia e neuroimaging","year":"2011","author":"Mandara","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1354\/vp.37-6-680","article-title":"Malignant teratoid medulloepithelioma in a llama","volume":"37","author":"Hendrix","year":"2000","journal-title":"Vet Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00401-020-02182-2","article-title":"ETMR a tumor entity in its infancy","volume":"140","author":"Lambo","year":"2020","journal-title":"Acta Neuropathol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1748-5827.2003.tb00136.x","article-title":"Medulloblastoma in a cat: clinical and MRI findings","volume":"44","author":"Kitagawa","year":"2003","journal-title":"J Small Anim Pract."},{"key":"B6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1292\/jvms.63.103","article-title":"A case of canine Primitive Neuroectodermal Tumor (PNET)","volume":"63","author":"Katayama","year":"2001","journal-title":"J Vet Med Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fvets.2019.00401","article-title":"Medulloblastoma in a 6 year old mixed breed dog: Surgical debulking and chemotherapy","volume":"6","author":"Lampe","year":"2019","journal-title":"Front Vet Sci."},{"key":"B8","first-page":"834","article-title":"Tumors of the nervous system","volume-title":"Tumors in Domestic Animals","author":"Higgins","year":"2017"},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00401-013-1228-0","article-title":"Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity","volume":"128","author":"Korshunov","year":"2014","journal-title":"Acta Neuropathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1177\/1040638718799390","article-title":"Embryonal central nervous system tumor in the brain of a goose","volume":"31","author":"McHale","year":"2019","journal-title":"J Vet Diagn Invest."},{"key":"B14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/ccr3.1925","article-title":"Clinical and magnetic resonance imaging findings of a cerebellar medulloblastoma in a heifer","volume":"7","author":"Francesio","year":"2019","journal-title":"Clin Case Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1136\/vr.150.15.488","article-title":"Early diagnosis of feline medulloblastoma in the vermis","volume":"150","author":"Kuwabara","year":"2002","journal-title":"Vet Rec."},{"key":"B16","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1177\/030098586900600510","article-title":"Medulloblastoma in calves","volume":"6","author":"Jolly","year":"1969","journal-title":"Vet Pathol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1111\/jvim.13568","article-title":"Bilateral trochlear nerve palsy as a consequence of cerebellar medulloblastoma: clinical and pathological findings in a calf","volume":"29","author":"Bianchi","year":"2015","journal-title":"J Vet Intern Med."},{"key":"B18","first-page":"703","article-title":"A medulloblastoma in a baboon (Papio papio)","volume":"30","author":"Berthe","year":"1980","journal-title":"Lab Anim Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1939-165X.2012.00404.x","article-title":"Cytologic and immunohistochemical characterization of a primitive neuroectodermal tumor in the brain of a dog","volume":"41","author":"Choi","year":"2012","journal-title":"Vet Clin Pathol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jcpa.2008.11.002","article-title":"Central primitive neuroectodermal tumour with ependymal differentiation in a Dog","volume":"140","author":"Headley","year":"2009","journal-title":"J Comp Pathol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1177\/0192623312444764","article-title":"Spontaneous cerebellar primitive neuroectodermal tumor in a juvenile Cynomolgus monkey (Macaca fascicularis)","volume":"40","author":"Mukaratirwa","year":"2012","journal-title":"Toxicol Pathol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1016\/j.humpath.2013.03.012","article-title":"Anaplastic ependymoma with ependymoblastic multilayered rosettes","volume":"44","author":"Nobusawa","year":"2013","journal-title":"Case Reports Hum Pathol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1097\/PAS.0b013e318186235b","article-title":"Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor","volume":"33","author":"Gessi","year":"2009","journal-title":"Am J Surg Pathol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s100249910049","article-title":"Pediatric neuroblastic brain tumors containing abundant neuropil and true rosettes","volume":"3","author":"Eberhart","year":"2000","journal-title":"Pediatr Dev Pathol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s11060-007-9346-y","article-title":"Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation","volume":"84","author":"Dunham","year":"2007","journal-title":"J Neuro-Oncol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"50","DOI":"10.4103\/1793-5482.151516","article-title":"Medulloblastoma: a common pediatric tumor: prognostic factors and predictors of outcome","volume":"10","author":"Kumar","year":"2015","journal-title":"Asian J Neurosurg."},{"key":"B27","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1177\/030098588402100513","article-title":"Ependymoblastoma in a dairy calf","volume":"529","author":"Saunders","year":"1984","journal-title":"Vet Pathol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1292\/jvms.001393","article-title":"Ependymoblastoma in a Japanese Black heifer","volume":"71","author":"Miyoshi","year":"2009","journal-title":"J Vet Med Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1365-2559.1988.tb01913.x","article-title":"Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases","volume":"12","author":"Cruz-Sanchez","year":"1988","journal-title":"Histopathology."},{"key":"B30","first-page":"75","article-title":"Medulloepithelioma in a cat","volume":"32","author":"Jel\u00ednek","year":"1996","journal-title":"Ceskoslovenska Patol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/ccr3.3602","article-title":"Retrobulbar embryonal tumor with multilayered rosettes in a Golden Retriever dog","volume":"9","author":"Martins","year":"2020","journal-title":"Clin Case Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3171\/2015.3.PEDS1525","article-title":"Embryonal tumor with multilayered rosettes of the fourth ventricle: case report","volume":"16","author":"Edmonson","year":"2015","journal-title":"J Neurosurg Pediatr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.3174\/ajnr.A4002","article-title":"MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases","volume":"35","author":"Nowak","year":"2014","journal-title":"Am J Neuroradiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1007\/s00381-017-3551-6","article-title":"LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid\/Rhabdoid Tumor (AT\/RT)","volume":"33","author":"Rao","year":"2017","journal-title":"Childs Nerv Syst."}],"container-title":["Frontiers in Veterinary Science"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.961056\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T08:40:24Z","timestamp":1661416824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.961056\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":34,"alternative-id":["10.3389\/fvets.2022.961056"],"URL":"https:\/\/doi.org\/10.3389\/fvets.2022.961056","relation":{},"ISSN":["2297-1769"],"issn-type":[{"type":"electronic","value":"2297-1769"}],"subject":[],"published":{"date-parts":[[2022,8,25]]},"article-number":"961056"}}